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Free fatty acid receptor

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G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.

Below are the list of possible Free fatty acid receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Free fatty acid receptor 1

 Free fatty acid receptor 1 ELISA Kit
 Free fatty acid receptor 1 Recombinant
 Free fatty acid receptor 1 Antibody
Also known as Free fatty acid receptor 1 (G-protein coupled receptor 40).
G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis;
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receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.
 FFAR1 ELISA Kit
 FFAR1 Recombinant
 FFAR1 Antibody
 GPR40 ELISA Kit
 GPR40 Recombinant
 GPR40 Antibody
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Free fatty acid receptor 2

 Free fatty acid receptor 2 ELISA Kit
 Free fatty acid receptor 2 Recombinant
 Free fatty acid receptor 2 Antibody
Also known as Free fatty acid receptor 2 (G-protein coupled receptor 43).
FFAR2: Receptor for short chain fatty acids through a G(i)- protein-mediated inhibition of adenylyl cyclase and elevation of intracellular calcium. The rank order of potency for agonists of this receptor is acetate= propionate = butyrate > pentanoate = formate. Belongs to the G-protein coupled receptor 1 family.
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>Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: cell projection; plasma membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: cell surface pattern recognition receptor signaling pathway; fat cell differentiation; G-protein coupled receptor protein signaling pathway; glucose homeostasis; leukocyte chemotaxis during inflammatory response; mucosal immune response; positive regulation of acute inflammatory response to non-antigenic stimulus; positive regulation of chemokine production; positive regulation of cytokine production during immune response; regulation of acute inflammatory response; sequestering of lipid
 Ffar2 ELISA Kit
 Ffar2 Recombinant
 Ffar2 Antibody
 Gpr43 ELISA Kit
 Gpr43 Recombinant
 Gpr43 Antibody
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Free fatty acid receptor 3

 Free fatty acid receptor 3 ELISA Kit
 Free fatty acid receptor 3 Recombinant
 Free fatty acid receptor 3 Antibody
Also known as Free fatty acid receptor 3 (G-protein coupled receptor 41).
FFAR3: Receptor for short chain fatty acids. The activity of this receptor is coupled to the formation of inositol 1,4,5- trisphosphate, intracellular Ca2+ mobilization, the activation of ERK 1/2 and inhibition of intracellular cAMP accumulation. Coupled exclusively to the pertussis toxin-sensitive G(i/o)-alpha protein. T
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he rank order of potency for agonists of this receptor is propionate = pentanoate = butyrate > acetate > formate. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; mucosal immune response; negative regulation of blood pressure; positive regulation of acute inflammatory response to non-antigenic stimulus; positive regulation of chemokine production; positive regulation of cytokine production during immune response; regulation of hormone biosynthetic process; regulation of norepinephrine secretion
 FFAR3 ELISA Kit
 FFAR3 Recombinant
 FFAR3 Antibody
 GPR41 ELISA Kit
 GPR41 Recombinant
 GPR41 Antibody
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Free fatty acid receptor 4

 Free fatty acid receptor 4 ELISA Kit
 Free fatty acid receptor 4 Recombinant
 Free fatty acid receptor 4 Antibody
Also known as Free fatty acid receptor 4 (G-protein coupled receptor 120) (G-protein coupled receptor 129) (G-protein coupled receptor GT01) (G-protein coupled receptor PGR4) (Omega-3 fatty acid receptor 1).
GPR120: Receptor for medium and long-chain free fatty acid (FAA). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1 dependent effect but independent of G(q)/G(11)-coupl
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ed pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 10q23.33

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: fatty acid binding; peptide binding; taste receptor activity

Biological Process: cellular response to hormone stimulus; hormone secretion; negative regulation of apoptosis; negative regulation of cytokine secretion; negative regulation of inflammatory response

Disease: Body Mass Index Quantitative Trait Locus 10
 FFAR4 ELISA Kit
 FFAR4 Recombinant
 FFAR4 Antibody
 GPR120 ELISA Kit
 GPR120 Recombinant
 GPR120 Antibody
 GPR129 ELISA Kit
 GPR129 Recombinant
 GPR129 Antibody
 O3FAR1 ELISA Kit
 O3FAR1 Recombinant
 O3FAR1 Antibody
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