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Frizzled

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Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.

Below are the list of possible Frizzled products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Frizzled

 Frizzled ELISA Kit
 Frizzled Recombinant
 Frizzled Antibody
Also known as Frizzled (Frizzled-1) (dFz1).
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of dishe
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veled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
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Frizzled-1

 Frizzled-1 ELISA Kit
 Frizzled-1 Recombinant
 Frizzled-1 Antibody
Also known as Frizzled-1 (Fz-1) (cFz-1).
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some fam
>>>
ily members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
 FZD1 ELISA Kit
 FZD1 Recombinant
 FZD1 Antibody
 FZ1 ELISA Kit
 FZ1 Recombinant
 FZ1 Antibody
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Frizzled-10

 Frizzled-10 ELISA Kit
 Frizzled-10 Recombinant
 Frizzled-10 Antibody
Also known as Frizzled-10 (Fz-10) (CD antigen CD350).
FZD10: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has b
>>>
een seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Belongs to the G-protein coupled receptor Fz/Smo family.

Protein type: GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: cell surface; cytoplasm; integral to membrane

Molecular Function: G-protein coupled receptor activity; Wnt receptor activity; Wnt-protein binding

Biological Process: positive regulation of GTPase activity; positive regulation of JNK activity; regulation of actin cytoskeleton organization and biogenesis; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin
 Fzd10 ELISA Kit
 Fzd10 Recombinant
 Fzd10 Antibody
 Fz10 ELISA Kit
 Fz10 Recombinant
 Fz10 Antibody
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Frizzled-10-A

 Frizzled-10-A ELISA Kit
 Frizzled-10-A Recombinant
 Frizzled-10-A Antibody
Also known as Frizzled-10-A (Fz-10A) (Xfz10-A).
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for s
>>>
ome family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt8. Could have an antagonizing activity in the morphogenesis during development.
 fzd10-a ELISA Kit
 fzd10-a Recombinant
 fzd10-a Antibody
 fz10a ELISA Kit
 fz10a Recombinant
 fz10a Antibody
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Frizzled-10-B

 Frizzled-10-B ELISA Kit
 Frizzled-10-B Recombinant
 Frizzled-10-B Antibody
Also known as Frizzled-10-B (Fz-10B) (Xfz10-B) (Frizzled-9) (Fz-9) (Xfz9).
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-medi
>>>
ated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt8. Could have an antagonizing activity in the morphogenesis during development.
 fzd10-b ELISA Kit
 fzd10-b Recombinant
 fzd10-b Antibody
 fz10b ELISA Kit
 fz10b Recombinant
 fz10b Antibody
 fz9 ELISA Kit
 fz9 Recombinant
 fz9 Antibody
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Frizzled-2

 Frizzled-2 ELISA Kit
 Frizzled-2 Recombinant
 Frizzled-2 Antibody
Receptor for Wnt proteins (PubMed:19855022, PubMed:20711352). Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members,
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but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of gsk-3 kinase. Both pathways seem to involve interactions with G-proteins (Probable). Required for the migration and axon formation and guidance of different neuronal cell types including canal-associated neurons (CAN), hermaphrodite-specific neurons (HSN), anterior lateral microtubule neurons (ALM), and the right Q neuroblast (QR) and its descendants (PubMed:16109397). Directs ALM migration through frizzled protein mom-5 and Wnt ligands cwn-1, cwn-2 and egl-20 (PubMed:16109397). May act redundantly with mom-5 to direct CAN migration (PubMed:16109397). Plays a role in the organization of head ganglion cells (PubMed:16109397). Probably by acting as a receptor for Wnt ligand cwn-2, plays a role in the positioning of the nerve ring and may in addition positively regulate the neurite outgrowth of RME GABAergic motor neurons along the anterior-posterior axis of the body (PubMed:19855022, PubMed:20711352).
 cfz-2 ELISA Kit
 cfz-2 Recombinant
 cfz-2 Antibody
 F27E11.3 ELISA Kit
 F27E11.3 Recombinant
 F27E11.3 Antibody
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Frizzled-3

 Frizzled-3 ELISA Kit
 Frizzled-3 Recombinant
 Frizzled-3 Antibody
Also known as Frizzled-3 (dFz3).
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family memb
>>>
ers, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
 fz3 ELISA Kit
 fz3 Recombinant
 fz3 Antibody
 CG16785 ELISA Kit
 CG16785 Recombinant
 CG16785 Antibody
Table BarTOPTable Bar
 

Frizzled-4

 Frizzled-4 ELISA Kit
 Frizzled-4 Recombinant
 Frizzled-4 Antibody
Also known as Frizzled-4 (dFz4).
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family memb
>>>
ers, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
 fz4 ELISA Kit
 fz4 Recombinant
 fz4 Antibody
 CG4626 ELISA Kit
 CG4626 Recombinant
 CG4626 Antibody
Table BarTOPTable Bar
 

Frizzled-5

 Frizzled-5 ELISA Kit
 Frizzled-5 Recombinant
 Frizzled-5 Antibody
Also known as Frizzled-5 (Fz-5).
FZD5: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some fami
>>>
ly members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. Interacts with GOPC. Belongs to the G-protein coupled receptor Fz/Smo family.

Protein type: GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: cell surface; early endosome; Golgi apparatus; integral to membrane; perinuclear region of cytoplasm; plasma membrane; tight junction

Molecular Function: G-protein coupled receptor activity; protein kinase binding; ubiquitin protein ligase binding; Wnt receptor activity; Wnt-protein binding

Biological Process: angiogenesis; cell maturation; determination of anterior/posterior axis, embryo; embryonic axis specification; embryonic camera-type eye development; embryonic camera-type eye morphogenesis; negative regulation of cell proliferation; positive regulation of interferon-gamma production; positive regulation of JNK activity; positive regulation of T cell cytokine production; positive regulation of transcription from RNA polymerase II promoter; post-embryonic camera-type eye development; Spemann organizer formation; T cell differentiation in the thymus; vasculature development; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin
 Fzd5 ELISA Kit
 Fzd5 Recombinant
 Fzd5 Antibody
Table BarTOPTable Bar
 

Frizzled-6

 Frizzled-6 ELISA Kit
 Frizzled-6 Recombinant
 Frizzled-6 Antibody
Also known as Frizzled-6 (Fz-6).
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family memb
>>>
ers, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear ().
 FZD6 ELISA Kit
 FZD6 Recombinant
 FZD6 Antibody
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Frizzled-7

 Frizzled-7 ELISA Kit
 Frizzled-7 Recombinant
 Frizzled-7 Antibody
Also known as Frizzled-7 (Frz7) (Fz-7).
Receptor for Wnt proteins. Acts in both canonical and non-canonical Wnt pathways. Although different papers report differing Wnt preferences, wnt5a, wnt8b and wnt11 have been proposed as synergists. In the canonical Wnt pathway, acts via beta-catenin to promote the expression of the dorsal genes siamois, twin and nodal3 and to establish the dorsal axis of
>>>
the embryo and induce dorsal mesoderm formation. In a non-canonical Wnt/planar cell polarity (PCP) pathway, acts with sdc4 and dvl2/dsh to regulate convergent extension movements in gastrulation. Triggers phosphorylation of dvl2/dsh and its translocation to the plasma membrane. In a third branch of Wnt signaling, acts in a non-canonical pathway via trimeric G proteins, and independently of dvl2/dsh, to recruit protein kinase C (PKC) to the membrane and thus activate PKC. PKC signaling controls cell sorting and tissue separation during gastrulation ().
 fzd7 ELISA Kit
 fzd7 Recombinant
 fzd7 Antibody
 TNeu065e03.1 ELISA Kit
 TNeu065e03.1 Recombinant
 TNeu065e03.1 Antibody
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Frizzled-7-A

 Frizzled-7-A ELISA Kit
 Frizzled-7-A Recombinant
 Frizzled-7-A Antibody
Also known as Frizzled-7-A (Fz-7-A) (Xfz7-A).
Receptor for Wnt proteins. Acts in both canonical and non-canonical Wnt pathways. Although different papers report differing Wnt preferences, wnt5a, wnt8b and wnt11 have been proposed as synergists. In the canonical Wnt pathway, acts via beta-catenin to promote the expression of the dorsal genes siamois, twin and nodal3 and to establish the dorsal a
>>>
xis of the embryo and induce dorsal mesoderm formation. In a non-canonical Wnt/planar cell polarity (PCP) pathway, acts with sdc4 and dvl2/dsh to regulate convergent extension cell movements during gastrulation. Triggers phosphorylation of dvl2/dsh and its translocation to the plasma membrane. In a third branch of Wnt signaling, acts in a non-canonical pathway via trimeric G proteins, and independently of dvl2/dsh, to recruit protein kinase C (PKC) to the membrane and thus activate PKC. PKC signaling controls cell sorting and tissue separation during gastrulation.
 fzd7-a ELISA Kit
 fzd7-a Recombinant
 fzd7-a Antibody
 fz7-a ELISA Kit
 fz7-a Recombinant
 fz7-a Antibody
Table BarTOPTable Bar
 

Frizzled-7-B

 Frizzled-7-B ELISA Kit
 Frizzled-7-B Recombinant
 Frizzled-7-B Antibody
Also known as Frizzled-7-B (Fz-7-B) (Xfz7-B).
Receptor for Wnt proteins. Acts in both canonical and non-canonical Wnt pathways. Although different papers report differing Wnt preferences, wnt5a, wnt8b and wnt11 have been proposed as synergists. In the canonical Wnt pathway, acts via beta-catenin to promote the expression of the dorsal genes siamois, twin and nodal3 and to establish the dorsal a
>>>
xis of the embryo and induce dorsal mesoderm formation. In a non-canonical Wnt/planar cell polarity (PCP) pathway, acts with sdc4 and dvl2/dsh to regulate convergent extension cell movements during gastrulation. Triggers phosphorylation of dvl2/dsh and its translocation to the plasma membrane. In a third branch of Wnt signaling, acts in a non-canonical pathway via trimeric G proteins, and independently of dvl2/dsh, to recruit protein kinase C (PKC) to the membrane and thus activate PKC. PKC signaling controls cell sorting and tissue separation during gastrulation.
 fzd7-b ELISA Kit
 fzd7-b Recombinant
 fzd7-b Antibody
 fz7-b ELISA Kit
 fz7-b Recombinant
 fz7-b Antibody
Table BarTOPTable Bar
 

Frizzled-8

 Frizzled-8 ELISA Kit
 Frizzled-8 Recombinant
 Frizzled-8 Antibody
Also known as Frizzled-8 (Fz-8).
FZD8: Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-cateni
>>>
n and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. Belongs to the G-protein coupled receptor Fz/Smo family.

Protein type: GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: integral to membrane

Molecular Function: G-protein coupled receptor activity; Wnt receptor activity; Wnt-protein binding

Biological Process: Wnt receptor signaling pathway through beta-catenin
 Fzd8 ELISA Kit
 Fzd8 Recombinant
 Fzd8 Antibody
Table BarTOPTable Bar
 

Frizzled-9

 Frizzled-9 ELISA Kit
 Frizzled-9 Recombinant
 Frizzled-9 Antibody
Also known as Frizzled-9 (Fz-9) (cFz-9).
Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.
 FZD9 ELISA Kit
 FZD9 Recombinant
 FZD9 Antibody
 FZ9 ELISA Kit
 FZ9 Recombinant
 FZ9 Antibody
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