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Fumarate hydratase

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CATALYTIC ACTIVITY: (S)-malate = fumarate + H(2)O.PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.

Below are the list of possible Fumarate hydratase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Fumarate hydratase 1

 Fumarate hydratase 1 ELISA Kit
 Fumarate hydratase 1 Recombinant
 Fumarate hydratase 1 Antibody
Also known as Fumarate hydratase 1, mitochondrial (Fumarase 1).
Encodes a mitochondrial-localized protein. The FUM1 gene appears to be essential, suggesting that FUM1 may play a crucial role as a fumarase in the tricarboxylic acid cycle.
 FUM1 ELISA Kit
 FUM1 Recombinant
 FUM1 Antibody
 At2g47510 ELISA Kit
 At2g47510 Recombinant
 At2g47510 Antibody
 T30B22.19 ELISA Kit
 T30B22.19 Recombinant
 T30B22.19 Antibody
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Fumarate hydratase 2

 Fumarate hydratase 2 ELISA Kit
 Fumarate hydratase 2 Recombinant
 Fumarate hydratase 2 Antibody
Also known as Fumarate hydratase 2, chloroplastic (Fumarase 2).
Encodes a fumarase enzyme initially shown to be in the mitochondria through proteomic studies but later shown to be present in the cytosol using an RFP fluorescent protein tag. It appears to be important for the accumulation of fumarate from malate in leaves in the light, and helps to promote nitrogen assimilation under high nitrogen conditions. It does not appear to be necessary for lipid metabolism and seedling growth.
 FUM2 ELISA Kit
 FUM2 Recombinant
 FUM2 Antibody
 At5g50950 ELISA Kit
 At5g50950 Recombinant
 At5g50950 Antibody
 K3K7.11 ELISA Kit
 K3K7.11 Recombinant
 K3K7.11 Antibody
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Fumarate hydratase class I, aerobic

 Fumarate hydratase class I, aerobic ELISA Kit
 Fumarate hydratase class I, aerobic Recombinant
 Fumarate hydratase class I, aerobic Antibody
Also known as Fumarate hydratase class I, aerobic (Fumarase A) (Oxaloacetate keto--enol-isomerase) (OAAKE isomerase) (Oxaloacetate tautomerase).
Catalyzes the reversible hydration of fumarate to (S)-malate. Functions as an aerobic enzyme in the direction of malate formation as part of the citric acid cycle. Accounts for about 80% of the fumarase activity when the bacteria grow aerobically. To a
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lesser extent, also displays D-tartrate dehydratase activity in vitro, but is not able to convert (R)-malate, L-tartrate or meso-tartrate. Can also catalyze the isomerization of enol- to keto-oxaloacetate.
 fumA ELISA Kit
 fumA Recombinant
 fumA Antibody
 c2004 ELISA Kit
 c2004 Recombinant
 c2004 Antibody
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Fumarate hydratase class I, anaerobic

 Fumarate hydratase class I, anaerobic ELISA Kit
 Fumarate hydratase class I, anaerobic Recombinant
 Fumarate hydratase class I, anaerobic Antibody
Also known as Fumarate hydratase class I, anaerobic (D-tartrate dehydratase) (Fumarase B).
FumB is required for anaerobic D-tartrate utilization and fumB mutants have reduced D-tartrate dehydratase activity (Kim, 2007). [More information is available at EcoGene: EG10357]. One of three isozymes in Escherichia coli, fumarase B is a Class I fumarase. [More information is available at EcoCyc: EG10357].
 fumB ELISA Kit
 fumB Recombinant
 fumB Antibody
 b4122 ELISA Kit
 b4122 Recombinant
 b4122 Antibody
 JW4083 ELISA Kit
 JW4083 Recombinant
 JW4083 Antibody
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Fumarate hydratase class II

 Fumarate hydratase class II ELISA Kit
 Fumarate hydratase class II Recombinant
 Fumarate hydratase class II Antibody
Also known as Fumarate hydratase class II (Fumarase C).
Catalyzes the reversible addition of water to fumarate to give L-malate.
 fumC ELISA Kit
 fumC Recombinant
 fumC Antibody
 Atu1616 ELISA Kit
 Atu1616 Recombinant
 Atu1616 Antibody
 AGR_C_2979 ELISA Kit
 AGR_C_2979 Recombinant
 AGR_C_2979 Antibody
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Fumarate hydratase class II 1

 Fumarate hydratase class II 1 ELISA Kit
 Fumarate hydratase class II 1 Recombinant
 Fumarate hydratase class II 1 Antibody
Also known as Fumarate hydratase class II 1 (Fumarase C 1).
Catalyzes the reversible addition of water to fumarate to give L-malate.
 fumC1 ELISA Kit
 fumC1 Recombinant
 fumC1 Antibody
 PA4470 ELISA Kit
 PA4470 Recombinant
 PA4470 Antibody
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Fumarate hydratase class II 2

 Fumarate hydratase class II 2 ELISA Kit
 Fumarate hydratase class II 2 Recombinant
 Fumarate hydratase class II 2 Antibody
Also known as Fumarate hydratase class II 2 (Fumarase C 2).
Catalyzes the reversible addition of water to fumarate to give L-malate.
 fumC2 ELISA Kit
 fumC2 Recombinant
 fumC2 Antibody
 bll0286 ELISA Kit
 bll0286 Recombinant
 bll0286 Antibody
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Fumarate hydratase

 Fumarate hydratase ELISA Kit
 Fumarate hydratase Recombinant
 Fumarate hydratase Antibody
Also known as Fumarate hydratase, mitochondrial (Fumarase).
FH: a metabolic enzyme that participates in the tricarboxylic acid cycle that catalyzes the conversion of (S)-malate into fumarate + H2O.
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There are two substrate binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors. Fumarate accumulates in the cell when FH is inactivated. Fumarate inhibits the dioxygenases that hydroxylate the transcription factor HIF and leads to its degradation by VHL. Since HIF turns on oncogenic pathways, FH has apparent tumor suppressor activity. Defects in FH are the cause of hereditary leiomyomatosis and renal cell cancer (HLRCC), a highly metastatic form of RCC. Defects in FH are the cause of fumarase deficiency (FD) also known as fumaricaciduria. FD is characterized by progressive encephalopathy, developmental delay, hypotonia, cerebral atrophy and lactic and pyruvic acidemia. Cells derived from a patient with HLRCC exhibit compromised oxidative phosphorylation, dependence on anaerobic glycolysis, rapid glycolytic flux, and overexpression of lactate dehydrogenase A (LDHA) and GLUT1. Two human isoforms are produced by alternative initiation. The longer isoform is mitochondrial, while the shorter form, missing residues 1-43, is cytoplasmic.

Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; EC 4.2.1.2; Lyase; Mitochondrial; Tumor suppressor

Cellular Component: cytosol; mitochondrion

Molecular Function: fumarate hydratase activity

Biological Process: fumarate metabolic process; homeostasis of number of cells within a tissue; malate metabolic process; protein tetramerization; tricarboxylic acid cycle
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