| FYVE and coiled-coil domain-containing protein 1 ELISA Kit|
FYVE and coiled-coil domain-containing protein 1 Recombinant
FYVE and coiled-coil domain-containing protein 1 Antibody
|FYCO1: May mediate microtubule plus end-directed vesicle transport. Defects in FYCO1 are the cause of cataract congenital autosomal recessive type 2 (CATC2). An opacification of the crystalline lens of the eye becoming evident at birth or in infancy. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static |
or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Pathogenic mutations in FYCO1 can affect intracellular transport of autophagocytic vesicles from the perinuclear area to the periphery, leading to an accumulation of large numbers of vesicles and hence loss of lens transparency (PubMed:21636066). 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Autophagy
Cellular Component: autophagic vacuole; intracellular membrane-bound organelle; late endosome; lysosome; membrane
| Fyco1 ELISA Kit|