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FYVE, RhoGEF and PH domain-containing protein

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Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.

Below are the list of possible FYVE, RhoGEF and PH domain-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

FYVE, RhoGEF and PH domain-containing protein 1

 FYVE, RhoGEF and PH domain-containing protein 1 ELISA Kit
 FYVE, RhoGEF and PH domain-containing protein 1 Recombinant
 FYVE, RhoGEF and PH domain-containing protein 1 Antibody
Also known as FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3).
FGD1: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell sh
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ape. Interacts with DBNL/ABP1 and CTTN. May interact with CCPG1. Binds CDC42. Expressed in fetal heart, brain, lung, kidney and placenta. Less expressed in liver; adult heart, brain, lung, pancreas and skeletal muscle.

Protein type: GEFs; GEFs, misc.

Cellular Component: cytoplasm; Golgi apparatus; lamellipodium; ruffle

Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; small GTPase binding

Biological Process: actin cytoskeleton organization and biogenesis; cytoskeleton organization and biogenesis; filopodium formation; regulation of cell shape; regulation of GTPase activity
 Fgd1 ELISA Kit
 Fgd1 Recombinant
 Fgd1 Antibody
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FYVE, RhoGEF and PH domain-containing protein 2

 FYVE, RhoGEF and PH domain-containing protein 2 ELISA Kit
 FYVE, RhoGEF and PH domain-containing protein 2 Recombinant
 FYVE, RhoGEF and PH domain-containing protein 2 Antibody
FGD2: an endosome and ruffle membrane-associated guanine nucleotide exchange factor (GEF) that activates CDC42, a small G protein of the Rho-subfamily. Interacts with RAB6A bound to GTP. Activates JNK1 via CDC42 but not RAC1. Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides. Binds to phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-trisph
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osphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4- monophosphate and phosphatidylinositol 3-monophosphate. The FYVE-type zinc-finger is necessary for early endosome localization. Recruitment to endosomal membranes via this domain requires the presence of phosphatidylinositol 3-phosphate or other phosphatidylinositides. The PH domain is necessary for localization to the ruffle membrane. Recruitment to ruffle membrane occurs through binding of phosphoinositides by the PH domain. This domain also contributes to the lipid-binding properties of the protein. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho

Cellular Component: cytoplasm; early endosome; nucleus; ruffle

Molecular Function: Rho guanyl-nucleotide exchange factor activity

Biological Process: positive regulation of JNK activity
 Fgd2 ELISA Kit
 Fgd2 Recombinant
 Fgd2 Antibody
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FYVE, RhoGEF and PH domain-containing protein 3

 FYVE, RhoGEF and PH domain-containing protein 3 ELISA Kit
 FYVE, RhoGEF and PH domain-containing protein 3 Recombinant
 FYVE, RhoGEF and PH domain-containing protein 3 Antibody
FGD3: Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho

Biological Process: filopodium formation
 Fgd3 ELISA Kit
 Fgd3 Recombinant
 Fgd3 Antibody
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FYVE, RhoGEF and PH domain-containing protein 4

 FYVE, RhoGEF and PH domain-containing protein 4 ELISA Kit
 FYVE, RhoGEF and PH domain-containing protein 4 Recombinant
 FYVE, RhoGEF and PH domain-containing protein 4 Antibody
Also known as FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein).
binds actin filaments; regulates changes in cell shape; involved in c-Jun N-terminal kinase activation [RGD, Feb 2006]
 Fgd4 ELISA Kit
 Fgd4 Recombinant
 Fgd4 Antibody
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FYVE, RhoGEF and PH domain-containing protein 5

 FYVE, RhoGEF and PH domain-containing protein 5 ELISA Kit
 FYVE, RhoGEF and PH domain-containing protein 5 Recombinant
 FYVE, RhoGEF and PH domain-containing protein 5 Antibody
FGD5: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. 2 isoforms of the human protei
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n are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho
 Fgd5 ELISA Kit
 Fgd5 Recombinant
 Fgd5 Antibody
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FYVE, RhoGEF and PH domain-containing protein 6

 FYVE, RhoGEF and PH domain-containing protein 6 ELISA Kit
 FYVE, RhoGEF and PH domain-containing protein 6 Recombinant
 FYVE, RhoGEF and PH domain-containing protein 6 Antibody
FGD6: May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho
 Fgd6 ELISA Kit
 Fgd6 Recombinant
 Fgd6 Antibody
 Kiaa1362 ELISA Kit
 Kiaa1362 Recombinant
 Kiaa1362 Antibody
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