Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.
Below are the list of possible FYVE, RhoGEF and PH domain-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications. |
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FYVE, RhoGEF and PH domain-containing protein 1 ELISA Kit
FYVE, RhoGEF and PH domain-containing protein 1 Recombinant
FYVE, RhoGEF and PH domain-containing protein 1 Antibody | Also known as FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3).
FGD1: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell sh >>> ape. Interacts with DBNL/ABP1 and CTTN. May interact with CCPG1. Binds CDC42. Expressed in fetal heart, brain, lung, kidney and placenta. Less expressed in liver; adult heart, brain, lung, pancreas and skeletal muscle.
Protein type: GEFs; GEFs, misc.
Cellular Component: cytoplasm; Golgi apparatus; lamellipodium; ruffle
Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; small GTPase binding
Biological Process: actin cytoskeleton organization and biogenesis; cytoskeleton organization and biogenesis; filopodium formation; regulation of cell shape; regulation of GTPase activity |
Fgd1 ELISA Kit
Fgd1 Recombinant
Fgd1 Antibody |
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FYVE, RhoGEF and PH domain-containing protein 2 ELISA Kit
FYVE, RhoGEF and PH domain-containing protein 2 Recombinant
FYVE, RhoGEF and PH domain-containing protein 2 Antibody | FGD2: an endosome and ruffle membrane-associated guanine nucleotide exchange factor (GEF) that activates CDC42, a small G protein of the Rho-subfamily. Interacts with RAB6A bound to GTP. Activates JNK1 via CDC42 but not RAC1. Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides. Binds to phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-trisph >>> osphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4- monophosphate and phosphatidylinositol 3-monophosphate. The FYVE-type zinc-finger is necessary for early endosome localization. Recruitment to endosomal membranes via this domain requires the presence of phosphatidylinositol 3-phosphate or other phosphatidylinositides. The PH domain is necessary for localization to the ruffle membrane. Recruitment to ruffle membrane occurs through binding of phosphoinositides by the PH domain. This domain also contributes to the lipid-binding properties of the protein. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs; GEFs, Rac/Rho
Cellular Component: cytoplasm; early endosome; nucleus; ruffle
Molecular Function: Rho guanyl-nucleotide exchange factor activity
Biological Process: positive regulation of JNK activity |
Fgd2 ELISA Kit
Fgd2 Recombinant
Fgd2 Antibody |
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Protein Family 
