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G protein-coupled receptor kinase

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Specifically phosphorylates the activated forms of G protein-coupled receptors.

Below are the list of possible G protein-coupled receptor kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

G protein-coupled receptor kinase 1

 G protein-coupled receptor kinase 1 ELISA Kit
 G protein-coupled receptor kinase 1 Recombinant
 G protein-coupled receptor kinase 1 Antibody
Specifically phosphorylates the activated forms of G protein-coupled receptors.
 grk-1 ELISA Kit
 grk-1 Recombinant
 grk-1 Antibody
 CBG01947 ELISA Kit
 CBG01947 Recombinant
 CBG01947 Antibody
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G protein-coupled receptor kinase 2

 G protein-coupled receptor kinase 2 ELISA Kit
 G protein-coupled receptor kinase 2 Recombinant
 G protein-coupled receptor kinase 2 Antibody
Specifically phosphorylates the activated forms of G protein-coupled receptors.
 grk-2 ELISA Kit
 grk-2 Recombinant
 grk-2 Antibody
 W02B3.2 ELISA Kit
 W02B3.2 Recombinant
 W02B3.2 Antibody
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G protein-coupled receptor kinase 4

 G protein-coupled receptor kinase 4 ELISA Kit
 G protein-coupled receptor kinase 4 Recombinant
 G protein-coupled receptor kinase 4 Antibody
Also known as G protein-coupled receptor kinase 4 (G protein-coupled receptor kinase GRK4).
GRK4: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DR
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D3. Phosphorylates ADRB2. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: AGC group; EC 2.7.11.16; GRK family; GRK subfamily; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)

Cellular Component: cell soma; cytosol; dendrite

Molecular Function: rhodopsin kinase activity

Biological Process: desensitization of G-protein coupled receptor protein signaling pathway; G-protein coupled receptor internalization; protein amino acid phosphorylation; receptor internalization
 Grk4 ELISA Kit
 Grk4 Recombinant
 Grk4 Antibody
 Gprk2l ELISA Kit
 Gprk2l Recombinant
 Gprk2l Antibody
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G protein-coupled receptor kinase 5

 G protein-coupled receptor kinase 5 ELISA Kit
 G protein-coupled receptor kinase 5 Recombinant
 G protein-coupled receptor kinase 5 Antibody
Also known as G protein-coupled receptor kinase 5 (G protein-coupled receptor kinase GRK5).
GRK5: Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein- coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosp
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horylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70- interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2- mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G- protein-coupled receptor, LRP6 during Wnt signaling (in vitro). Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

Protein type: AGC group; EC 2.7.11.16; GRK family; GRK subfamily; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)

Cellular Component: plasma membrane

Molecular Function: protein serine/threonine kinase activity

Biological Process: negative regulation of apoptosis; protein amino acid autophosphorylation
 GRK5 ELISA Kit
 GRK5 Recombinant
 GRK5 Antibody
 GPRK5 ELISA Kit
 GPRK5 Recombinant
 GPRK5 Antibody
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G protein-coupled receptor kinase 6

 G protein-coupled receptor kinase 6 ELISA Kit
 G protein-coupled receptor kinase 6 Recombinant
 G protein-coupled receptor kinase 6 Antibody
Also known as G protein-coupled receptor kinase 6 (G protein-coupled receptor kinase GRK6).
GRK6: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dop
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amin receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). Widely expressed. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: AGC group; EC 2.7.11.16; GRK family; GRK subfamily; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: membrane; plasma membrane

Molecular Function: beta-adrenergic receptor kinase activity; protein binding

Biological Process: regulation of G-protein coupled receptor protein signaling pathway
 GRK6 ELISA Kit
 GRK6 Recombinant
 GRK6 Antibody
 GPRK6 ELISA Kit
 GPRK6 Recombinant
 GPRK6 Antibody
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