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G/T mismatch-specific thymine DNA glycosylase

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DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine . Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.

Below are the list of possible G/T mismatch-specific thymine DNA glycosylase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

G/T mismatch-specific thymine DNA glycosylase

 G/T mismatch-specific thymine DNA glycosylase ELISA Kit
 G/T mismatch-specific thymine DNA glycosylase Recombinant
 G/T mismatch-specific thymine DNA glycosylase Antibody
Also known as G/T mismatch-specific thymine DNA glycosylase (C-JUN leucine zipper interactive protein JZA-3) (Thymine-DNA glycosylase).
TDG: In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar- phosph
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ate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine. Belongs to the TDG/mug DNA glycosylase family.

Protein type: DNA repair, damage; EC 3.2.2.29; Hydrolase; Nuclear receptor co-regulator

Cellular Component: nucleoplasm; nucleus; plasma membrane; PML body

Molecular Function: DNA N-glycosylase activity; double-stranded DNA binding; mismatched DNA binding; protein binding; protein domain specific binding; protein homodimerization activity; protein kinase C binding; pyrimidine-specific mismatch base pair DNA N-glycosylase activity; structure-specific DNA binding; SUMO binding; transcription factor binding; uracil DNA N-glycosylase activity

Biological Process: base-excision repair; base-excision repair, AP site formation; embryonic development; mismatch repair; negative regulation of protein binding; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic
 Tdg ELISA Kit
 Tdg Recombinant
 Tdg Antibody
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