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Gamma-aminobutyric acid receptor-associated protein

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Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).

Below are the list of possible Gamma-aminobutyric acid receptor-associated protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Gamma-aminobutyric acid receptor-associated protein

 Gamma-aminobutyric acid receptor-associated protein ELISA Kit
 Gamma-aminobutyric acid receptor-associated protein Recombinant
 Gamma-aminobutyric acid receptor-associated protein Antibody
Also known as Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein).
Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential fo
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r a later stage in autophagosome maturation ().
 GABARAP ELISA Kit
 GABARAP Recombinant
 GABARAP Antibody
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Gamma-aminobutyric acid receptor-associated protein-like 1

 Gamma-aminobutyric acid receptor-associated protein-like 1 ELISA Kit
 Gamma-aminobutyric acid receptor-associated protein-like 1 Recombinant
 Gamma-aminobutyric acid receptor-associated protein-like 1 Antibody
Also known as Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1).
GABARAPL1: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the forma
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tion of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Belongs to the MAP1 LC3 family. Interacts with GABRG2 and beta-tubulin. Interacts with KOR-1.

Protein type: Adaptor/scaffold; Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle

Chromosomal Location of Human Ortholog: 12p13.2

Cellular Component: autophagic vacuole; cytosol; intracellular; mitochondrion

Molecular Function: beta-tubulin binding; GABA receptor binding; protein binding; Tat protein binding; ubiquitin protein ligase binding

Biological Process: autophagic vacuole formation; cellular response to nitrogen starvation; macroautophagy; mitochondrion degradation
 GABARAPL1 ELISA Kit
 GABARAPL1 Recombinant
 GABARAPL1 Antibody
 GEC1 ELISA Kit
 GEC1 Recombinant
 GEC1 Antibody
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Gamma-aminobutyric acid receptor-associated protein-like 2

 Gamma-aminobutyric acid receptor-associated protein-like 2 ELISA Kit
 Gamma-aminobutyric acid receptor-associated protein-like 2 Recombinant
 Gamma-aminobutyric acid receptor-associated protein-like 2 Antibody
Also known as Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein).
GABARAPL2: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two e
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volutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. Implicated in intra-Golgi transport and post-mitotic Golgi re-assembly. Modulates the activity of SNAREs in the Golgi apparatus and is therefore an essential component of intra-Golgi transport and post-mitotic Golgi re-assembly. It first stimulates the ATPase activity of NSF, which in turn stimulates the association with GOSR1. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin. Interacts with ULK1. Phosphorylated upon DNA damage, probably by ATM or ATR.

Protein type: Adaptor/scaffold; Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle

Cellular Component: autophagic vacuole; cytosol; Golgi membrane

Molecular Function: ATPase binding; SNARE binding

Biological Process: autophagic vacuole formation; cellular response to nitrogen starvation; intra-Golgi vesicle-mediated transport; mitochondrion degradation; positive regulation of ATPase activity
 GABARAPL2 ELISA Kit
 GABARAPL2 Recombinant
 GABARAPL2 Antibody
 GEF2 ELISA Kit
 GEF2 Recombinant
 GEF2 Antibody
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Gamma-aminobutyric acid receptor-associated protein-like 3

 Gamma-aminobutyric acid receptor-associated protein-like 3 ELISA Kit
 Gamma-aminobutyric acid receptor-associated protein-like 3 Recombinant
 Gamma-aminobutyric acid receptor-associated protein-like 3 Antibody
Also known as Gamma-aminobutyric acid receptor-associated protein-like 3 (GABA(A) receptor-associated protein-like 3).
Ubiquitin-like modifier involved in autophagosome formation. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation ().
 GABARAPL3 ELISA Kit
 GABARAPL3 Recombinant
 GABARAPL3 Antibody
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