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Gamma-aminobutyric acid type B receptor

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Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Below are the list of possible Gamma-aminobutyric acid type B receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Gamma-aminobutyric acid type B receptor subunit 1

 Gamma-aminobutyric acid type B receptor subunit 1 ELISA Kit
 Gamma-aminobutyric acid type B receptor subunit 1 Recombinant
 Gamma-aminobutyric acid type B receptor subunit 1 Antibody
Also known as Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1).
GABBR1: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydroly
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sis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1. Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: axolemma; cell soma; cytoplasm; dendritic shaft; dendritic spine; endoplasmic reticulum membrane; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; lipid raft; membrane; mitochondrial membrane; neuron projection; postsynaptic membrane; presynaptic membrane; synaptic vesicle

Molecular Function: GABA-B receptor activity; protein binding; transcription factor binding

Biological Process: G-protein signaling, adenylate cyclase inhibiting pathway; gamma-aminobutyric acid signaling pathway; negative regulation of adenylate cyclase activity; negative regulation of cell proliferation; negative regulation of dopamine secretion; negative regulation of epinephrine secretion; negative regulation of gamma-aminobutyric acid secretion; negative regulation of synaptic transmission; osteoblast differentiation; positive regulation of glutamate secretion; positive regulation of growth hormone secretion; regulation of cAMP biosynthetic process; regulation of glutamate secretion
 Gabbr1 ELISA Kit
 Gabbr1 Recombinant
 Gabbr1 Antibody
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Gamma-aminobutyric acid type B receptor subunit 2

 Gamma-aminobutyric acid type B receptor subunit 2 ELISA Kit
 Gamma-aminobutyric acid type B receptor subunit 2 Recombinant
 Gamma-aminobutyric acid type B receptor subunit 2 Antibody
Also known as Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51).
GABBR2: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulate
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s inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region. Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.

Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: cytoplasm; integral to membrane; integral to plasma membrane; neuron projection

Molecular Function: GABA-B receptor activity; protein binding

Biological Process: gamma-aminobutyric acid signaling pathway
 Gabbr2 ELISA Kit
 Gabbr2 Recombinant
 Gabbr2 Antibody
 Gpr51 ELISA Kit
 Gpr51 Recombinant
 Gpr51 Antibody
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