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Gamma-secretase

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Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors precursor protein. It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity).

Below are the list of possible Gamma-secretase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Gamma-secretase subunit Aph-1

 Gamma-secretase subunit Aph-1 ELISA Kit
 Gamma-secretase subunit Aph-1 Recombinant
 Gamma-secretase subunit Aph-1 Antibody
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors precursor protein. It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex ().
 aph1 ELISA Kit
 aph1 Recombinant
 aph1 Antibody
 DDB_G0267976 ELISA Kit
 DDB_G0267976 Recombinant
 DDB_G0267976 Antibody
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Gamma-secretase subunit APH-1A

 Gamma-secretase subunit APH-1A ELISA Kit
 Gamma-secretase subunit APH-1A Recombinant
 Gamma-secretase subunit APH-1A Antibody
Also known as Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha).
APH1A: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable comp
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lex. Belongs to the APH-1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: endoplasmic reticulum; Golgi apparatus; integral to membrane; integral to plasma membrane; membrane

Molecular Function: endopeptidase activity; peptidase activity; protein binding

Biological Process: amyloid precursor protein catabolic process; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; metanephros development; Notch receptor processing; Notch signaling pathway; positive regulation of catalytic activity; protein processing
 Aph1a ELISA Kit
 Aph1a Recombinant
 Aph1a Antibody
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Gamma-secretase subunit Aph-1b

 Gamma-secretase subunit Aph-1b ELISA Kit
 Gamma-secretase subunit Aph-1b Recombinant
 Gamma-secretase subunit Aph-1b Antibody
Also known as Gamma-secretase subunit Aph-1b (Anterior-pharynx-defective protein 1b).
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex ().
 aph1b ELISA Kit
 aph1b Recombinant
 aph1b Antibody
 psfl ELISA Kit
 psfl Recombinant
 psfl Antibody
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Gamma-secretase subunit APH1-like

 Gamma-secretase subunit APH1-like ELISA Kit
 Gamma-secretase subunit APH1-like Recombinant
 Gamma-secretase subunit APH1-like Antibody
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.
 At2g31440 ELISA Kit
 At2g31440 Recombinant
 At2g31440 Antibody
 T28P16.7 ELISA Kit
 T28P16.7 Recombinant
 T28P16.7 Antibody
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Gamma-secretase subunit PEN-2

 Gamma-secretase subunit PEN-2 ELISA Kit
 Gamma-secretase subunit PEN-2 Recombinant
 Gamma-secretase subunit PEN-2 Antibody
Also known as Gamma-secretase subunit PEN-2 (Liver regeneration-related protein LRRGT00140) (Presenilin enhancer protein 2).
PSENEN: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). Probably represents the last step of maturation of
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gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN/PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Belongs to the PEN-2 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: endoplasmic reticulum; Golgi apparatus; integral to plasma membrane

Biological Process: membrane protein ectodomain proteolysis; Notch receptor processing; positive regulation of catalytic activity; protein processing
 Psenen ELISA Kit
 Psenen Recombinant
 Psenen Antibody
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