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GDP-4-keto-6-deoxy-D-mannose-3-dehydratase / pyridoxamine-phosphate transaminase

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Involved in the biosynthesis of L-colitose, a 3,6-dideoxyhexose present in the O-antigen region of lipopolysaccharides (LPS), where it serves as an antigenic determinant and is vital for bacterial defense and survival. Catalyzes the removal of the C3'-hydroxyl group from GDP-4-keto-6-deoxy-D-mannose via a combined transamination-deoxygenation reaction. The catalysis is initiated by a transamination step in which pyridoxal 5'-phosphate (PLP) is converted to pyridoxamine 5'-phosphate (PMP) in the presence of L-glutamate. This coenzyme then forms a Schiff base with GDP-4-keto-6-deoxy-D-mannose and the resulting adduct undergoes a PMP-mediated beta-dehydration reaction to give a sugar enamine intermediate, which after tautomerization and hydrolysis to release ammonia yields GDP-4-keto-3,6-dideoxy-D-mannose as a product.

Below are the list of possible GDP-4-keto-6-deoxy-D-mannose-3-dehydratase / pyridoxamine-phosphate transaminase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

GDP-4-keto-6-deoxy-D-mannose-3-dehydratase / pyridoxamine-phosphate transaminase

 GDP-4-keto-6-deoxy-D-mannose-3-dehydratase / pyridoxamine-phosphate transaminase ELISA Kit
 GDP-4-keto-6-deoxy-D-mannose-3-dehydratase / pyridoxamine-phosphate transaminase Recombinant
 GDP-4-keto-6-deoxy-D-mannose-3-dehydratase / pyridoxamine-phosphate transaminase Antibody
Involved in the biosynthesis of the L-colitose (3,6-dideoxyl-L-xylo-hexose) present in the O-antigen region of lipopolysaccharides (LPS) where it serves as an antigenic determinant and is vital for bacterial defense and survival. Catalyzes the C-3 deoxygenation of GDP-4-keto-6-deoxy-D-mannose via a combined transamination-deoxygenation reaction. The catalysis is initiated by a transamination step
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in which pyridoxal 5'-phosphate (PLP) is converted to pyridoxamine 5'-phosphate (PMP) in the presence of L-glutamate. Then, ColD forms a Schiff base with GDP-4-keto-6-deoxy-D-mannose and the resulting adduct undergoes a PMP-mediated beta-dehydration reaction to give a sugar enamine intermediate, which after tautomerization and hydrolysis releases ammonia to yield GDP-4-keto-3,6-dideoxy-D-mannose as a product.
 colD ELISA Kit
 colD Recombinant
 colD Antibody
 colA ELISA Kit
 colA Recombinant
 colA Antibody
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