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GDP-fucose protein O-fucosyltransferase

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Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in Notch signaling. Initial fucosylation of Notch/N by POFUT1 generates a substrate for Fringe/Fng, an acetylglucosaminyltransferase that can then extend the fucosylation on the Notch EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by Delta/Dl or Serrate/Ser. Also required for the transport of Notch/N to the early endosome.

Below are the list of possible GDP-fucose protein O-fucosyltransferase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

GDP-fucose protein O-fucosyltransferase 1

 GDP-fucose protein O-fucosyltransferase 1 ELISA Kit
 GDP-fucose protein O-fucosyltransferase 1 Recombinant
 GDP-fucose protein O-fucosyltransferase 1 Antibody
Also known as GDP-fucose protein O-fucosyltransferase 1 (Neurotic protein) (Peptide-O-fucosyltransferase 1) (O-FucT-1).
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in Notch signaling. Initial fucosylation of Notch/N by POFUT1 generat
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es a substrate for Fringe/Fng, an acetylglucosaminyltransferase that can then extend the fucosylation on the Notch EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by Delta/Dl or Serrate/Ser. Also required for the transport of Notch/N to the early endosome.
 O-fut1 ELISA Kit
 O-fut1 Recombinant
 O-fut1 Antibody
 nti ELISA Kit
 nti Recombinant
 nti Antibody
 CG12366 ELISA Kit
 CG12366 Recombinant
 CG12366 Antibody
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GDP-fucose protein O-fucosyltransferase 2

 GDP-fucose protein O-fucosyltransferase 2 ELISA Kit
 GDP-fucose protein O-fucosyltransferase 2 Recombinant
 GDP-fucose protein O-fucosyltransferase 2 Antibody
Also known as GDP-fucose protein O-fucosyltransferase 2 (Patterning defective protein 2) (Peptide-O-fucosyltransferase 2) (O-FucT-2).
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of
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the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS superfamily and the thrombosporin (TSP) and spondin families. Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13 ().
 pad-2 ELISA Kit
 pad-2 Recombinant
 pad-2 Antibody
 K10G9.3 ELISA Kit
 K10G9.3 Recombinant
 K10G9.3 Antibody
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