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Geminin

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Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.; Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.

Below are the list of possible Geminin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Geminin

 Geminin ELISA Kit
 Geminin Recombinant
 Geminin Antibody
Geminin: Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Homotetramer. Interacts with CDT1; inhibits binding of the MCM complex to origins of replication. Interacts with IDAS;
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targets GMNN to the nucleus, prevents GMNN interaction with CDT1 and competes with IDAS homodimerization. Belongs to the geminin family.

Protein type: Cell cycle regulation; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: histone deacetylase binding; protein binding

Biological Process: negative regulation of cell cycle; negative regulation of DNA replication; negative regulation of transcription, DNA-dependent

Disease: Meier-gorlin Syndrome 6
 GMNN ELISA Kit
 GMNN Recombinant
 GMNN Antibody
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