| Gigaxonin ELISA Kit|
|GAN: Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and su |
rvival. Defects in GAN are the cause of giant axonal neuropathy (GAN). GAN is a severe autosomal recessive sensorimotor neuropathy affecting both the peripheral nerves and the central nervous system. It is characterized by neurofilament accumulation, leading to segmental distention of axons.
Cellular Component: cytoplasm
Molecular Function: ubiquitin-protein ligase activity
Biological Process: cytoskeleton organization and biogenesis; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
| Gan ELISA Kit|