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Gliomedin

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Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.

Below are the list of possible Gliomedin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Gliomedin

 Gliomedin ELISA Kit
 Gliomedin Recombinant
 Gliomedin Antibody
GLDN: Plays a role in the formation of the nodes of Ranvier along myelinated axons. Probable NRCAM and NFASC/neurofascin ligand which may provide a glial positional clue required for the proper molecular assembly of the nodes of Ranvier. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q21.2

Disease: Lethal Congenital Contracture Syndrome 11
 GLDN ELISA Kit
 GLDN Recombinant
 GLDN Antibody
 COLM ELISA Kit
 COLM Recombinant
 COLM Antibody
 UNQ9339/PRO34011 ELISA Kit
 UNQ9339/PRO34011 Recombinant
 UNQ9339/PRO34011 Antibody
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