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Glucokinase regulatory protein

Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.

Below are the list of possible Glucokinase regulatory protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Glucokinase regulatory protein

 Glucokinase regulatory protein ELISA Kit
 Glucokinase regulatory protein Recombinant
 Glucokinase regulatory protein Antibody
Also known as Glucokinase regulatory protein (GKRP) (Glucokinase regulator).
GCKR: a key regulator of glucokinase in the liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen. When expressed alone, both glucokinase and GCKR localize predominantly to the cytoplasm. Co-expression induces both proteins to localize in t
he nucleus.

Protein type: Inhibitor; Mitochondrial

Chromosomal Location of Human Ortholog: 2p23

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function: protein binding

Biological Process: negative regulation of glucokinase activity; protein import into nucleus, translocation; response to fructose stimulus; urate metabolic process

Disease: Fasting Plasma Glucose Level Quantitative Trait Locus 5
 GCKR Recombinant
 GCKR Antibody
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