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Glypican

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Cell surface proteoglycan that bears heparan sulfate.

Below are the list of possible Glypican products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Glypican-1

 Glypican-1 ELISA Kit
 Glypican-1 Recombinant
 Glypican-1 Antibody
Cell surface proteoglycan that bears heparan sulfate.
 gpc1 ELISA Kit
 gpc1 Recombinant
 gpc1 Antibody
 zgc:122977 ELISA Kit
 zgc:122977 Recombinant
 zgc:122977 Antibody
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Glypican-2

 Glypican-2 ELISA Kit
 Glypican-2 Recombinant
 Glypican-2 Antibody
GPC2: Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons. Belongs to the glypican family.

Protein type: Membrane protein, GPI anchor

Cellular Component: endoplasmic reticulum

Biological Process: neuron differentiation; smoothened signaling pathway
 Gpc2 ELISA Kit
 Gpc2 Recombinant
 Gpc2 Antibody
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Glypican-3

 Glypican-3 ELISA Kit
 Glypican-3 Recombinant
 Glypican-3 Antibody
GPC3: Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. Defects in GPC3 are the ca
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use of Simpson-Golabi-Behmel syndrome type 1 (SGBS1); also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies. Belongs to the glypican family.

Protein type: Membrane protein, GPI anchor; Motility/polarity/chemotaxis

Cellular Component: anchored to plasma membrane; integral to plasma membrane; lysosome; plasma membrane

Molecular Function: protein binding

Biological Process: anterior/posterior axis specification; body morphogenesis; bone mineralization; embryonic hindlimb morphogenesis; kidney development; lung development; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of growth; negative regulation of smoothened signaling pathway; organ morphogenesis; osteoclast differentiation; positive regulation of BMP signaling pathway; positive regulation of endocytosis; positive regulation of glucose import; positive regulation of protein catabolic process; positive regulation of smoothened signaling pathway; regulation of growth; ureteric bud branching
 Gpc3 ELISA Kit
 Gpc3 Recombinant
 Gpc3 Antibody
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Glypican-4

 Glypican-4 ELISA Kit
 Glypican-4 Recombinant
 Glypican-4 Antibody
Also known as Glypican-4 (K-glypican).
GPC4: Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system. Belongs to the glypican family.

Protein type: Membrane protein, GPI anchor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: Xq26.1

Cellular Component: external side of
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plasma membrane; Golgi lumen; integral to plasma membrane; lysosomal lumen; nucleus; plasma membrane

Biological Process: anatomical structure morphogenesis; cell proliferation; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; retinoid metabolic process

Disease: Simpson-golabi-behmel Syndrome, Type 1; Wilms Tumor 1
 GPC4 ELISA Kit
 GPC4 Recombinant
 GPC4 Antibody
 UNQ474/PRO937 ELISA Kit
 UNQ474/PRO937 Recombinant
 UNQ474/PRO937 Antibody
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Glypican-5

 Glypican-5 ELISA Kit
 Glypican-5 Recombinant
 Glypican-5 Antibody
GPC5: Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.

Protein type: Cell surface; Membrane protein, GPI anchor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 13q32

Cellular Component: extracellular region; Golgi lumen; integral to plasma membrane; lysosomal lumen; plasma membrane

Biological Process: glycosamin
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oglycan biosynthetic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; retinoid metabolic process
 GPC5 ELISA Kit
 GPC5 Recombinant
 GPC5 Antibody
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Glypican-6

 Glypican-6 ELISA Kit
 Glypican-6 Recombinant
 Glypican-6 Antibody
GPC6: Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Enhances migration and invasion of cancer cells through WNT5A signaling. Defects in GPC6 are a cause of omodysplasia type 1 (OMOD1). OMOD1 is a rare autosomal recessive skeletal dysplasia characterized by severe congenital mic
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romelia with shortening and distal tapering of the humeri and femora to give a club-like appearance. Typical facial features include a prominent forehead, frontal bossing, short nose with a depressed broad bridge, short columella, anteverted nostrils, long philtrum, and small chin. Point mutations leading to protein truncation, as well as larger genomic rearrangements resulting in exon deletions, have been found in family segregating omodysplasia type 1. All mutations identified in individuals affected by omodysplasia could lead to the absence of a functional protein, the mutant RNAs being suspected to be nonsense-mediated mRNA decay (NMD) targets. Even if the mRNA escapes NMD and is translated, all mutations are expected to disrupt the three-dimensional protein structure and often to abolish multiple highly conserved cysteine residues. Belongs to the glypican family.

Protein type: Cell surface; Membrane protein, GPI anchor; Motility/polarity/chemotaxis

Cellular Component: integral to plasma membrane; nucleus

Biological Process: cell migration
 Gpc6 ELISA Kit
 Gpc6 Recombinant
 Gpc6 Antibody
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