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Granzyme

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Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity).

Below are the list of possible Granzyme products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Granzyme A

 Granzyme A ELISA Kit
 Granzyme A Recombinant
 Granzyme A Antibody
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189',
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which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA ().
 GZMA ELISA Kit
 GZMA Recombinant
 GZMA Antibody
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Granzyme B

 Granzyme B ELISA Kit
 Granzyme B Recombinant
 Granzyme B Antibody
Also known as Granzyme B (C11) (CTLA-1) (Cathepsin G-like 1) (CTSGL1) (Cytotoxic T-lymphocyte proteinase 2) (Lymphocyte protease) (Fragmentin-2) (Granzyme-2) (Human lymphocyte protein) (HLP) (SECT) (T-cell serine protease 1-3E).
GZMB: This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. By staphylococcal enterotoxin A (SEA) i
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n peripheral blood leukocytes. Inactivated by the serine protease inhibitor diisopropylfluorophosphate. Belongs to the peptidase S1 family. Granzyme subfamily.

Protein type: Apoptosis; EC 3.4.21.79; Protease

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: cytoplasm; cytosol; immunological synapse; intracellular membrane-bound organelle; membrane; nucleus

Molecular Function: protein binding; serine-type endopeptidase activity; serine-type peptidase activity

Biological Process: apoptosis; natural killer cell mediated cytotoxicity; protein processing
 GZMB ELISA Kit
 GZMB Recombinant
 GZMB Antibody
 CGL1 ELISA Kit
 CGL1 Recombinant
 CGL1 Antibody
 CSPB ELISA Kit
 CSPB Recombinant
 CSPB Antibody
 CTLA1 ELISA Kit
 CTLA1 Recombinant
 CTLA1 Antibody
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Granzyme C

 Granzyme C ELISA Kit
 Granzyme C Recombinant
 Granzyme C Antibody
Also known as Granzyme C (B10) (Cytotoxic cell protease 2) (CCP2).
GZMC: This enzyme is probably necessary for target cell lysis in cell-mediated immune responses. Belongs to the peptidase S1 family. Granzyme subfamily.

Protein type: EC 3.4.21.-

Cellular Component: cytoplasm; intracellular membrane-bound organelle

Molecular Function: serine-type endopeptidase activity

Biological Process: immune response; protein processing
 Gzmc ELISA Kit
 Gzmc Recombinant
 Gzmc Antibody
 Ctla-5 ELISA Kit
 Ctla-5 Recombinant
 Ctla-5 Antibody
 Ctla5 ELISA Kit
 Ctla5 Recombinant
 Ctla5 Antibody
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Granzyme D

 Granzyme D ELISA Kit
 Granzyme D Recombinant
 Granzyme D Antibody
Gzmd: This enzyme is probably necessary for target cell lysis in cell-mediated immune responses. Belongs to the peptidase S1 family. Granzyme subfamily.

Protein type: EC 3.4.21.-

Cellular Component: cytoplasm; intracellular membrane-bound organelle; membrane

Molecular Function: serine-type endopeptidase activity

Biological Process: immune response; protein processing
 Gzmd ELISA Kit
 Gzmd Recombinant
 Gzmd Antibody
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Granzyme E

 Granzyme E ELISA Kit
 Granzyme E Recombinant
 Granzyme E Antibody
Also known as Granzyme E (CTL serine protease 2) (Cytotoxic cell protease 3) (CCP3) (Cytotoxic serine protease 2) (D12) (MCSP2).
GZME: This enzyme is probably necessary for target cell lysis in cell-mediated immune responses. Belongs to the peptidase S1 family. Granzyme subfamily.

Protein type: EC 3.4.21.-

Cellular Component: cytoplasm; intracellular membrane-bound organelle; membrane

Molecular Function: serine-type endopeptidase activity

Biological Process: immune response; protein processing
 Gzme ELISA Kit
 Gzme Recombinant
 Gzme Antibody
 Ccp3 ELISA Kit
 Ccp3 Recombinant
 Ccp3 Antibody
 Ctla-6 ELISA Kit
 Ctla-6 Recombinant
 Ctla-6 Antibody
 Ctla6 ELISA Kit
 Ctla6 Recombinant
 Ctla6 Antibody
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Granzyme F

 Granzyme F ELISA Kit
 Granzyme F Recombinant
 Granzyme F Antibody
Also known as Granzyme F (C134) (CTL serine protease 3) (Cytotoxic cell protease 4) (CCP4) (Cytotoxic serine protease 3) (MCSP3).
GZMF: Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Belongs to the peptidase S1 family. Granzyme subfamily.

Protein type: EC 3.4.21.-; Protease

Cellular Component: cytoplasm; intracellular membrane-bound organelle; membrane

Molecular Function: serine-type end
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opeptidase activity

Biological Process: immune response; protein processing
 Gzmf ELISA Kit
 Gzmf Recombinant
 Gzmf Antibody
 Ccp4 ELISA Kit
 Ccp4 Recombinant
 Ccp4 Antibody
 Ctla-7 ELISA Kit
 Ctla-7 Recombinant
 Ctla-7 Antibody
 Ctla7 ELISA Kit
 Ctla7 Recombinant
 Ctla7 Antibody
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Granzyme G

 Granzyme G ELISA Kit
 Granzyme G Recombinant
 Granzyme G Antibody
Also known as Granzyme G (CTL serine protease 1) (MCSP-1).
GZMG: This enzyme is probably necessary for target cell lysis in cell-mediated immune responses. Belongs to the peptidase S1 family. Granzyme subfamily.

Cellular Component: cytoplasm; intracellular membrane-bound organelle; membrane

Molecular Function: serine-type endopeptidase activity

Biological Process: immune re
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sponse; protein processing
 Gzmg ELISA Kit
 Gzmg Recombinant
 Gzmg Antibody
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Granzyme H

 Granzyme H ELISA Kit
 Granzyme H Recombinant
 Granzyme H Antibody
Also known as Granzyme H (CCP-X) (Cathepsin G-like 2) (CTSGL2) (Cytotoxic T-lymphocyte proteinase) (Cytotoxic serine protease C) (CSP-C).
GZMF: Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Belongs to the peptidase S1 family. Granzyme subfamily.

Protein type: EC 3.4.21.-; Protease

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: cytoplasm; intracellular membrane-bound
>>>
organelle; membrane

Molecular Function: serine-type endopeptidase activity

Biological Process: immune response; protein processing
 GZMH ELISA Kit
 GZMH Recombinant
 GZMH Antibody
 CGL2 ELISA Kit
 CGL2 Recombinant
 CGL2 Antibody
 CTSGL2 ELISA Kit
 CTSGL2 Recombinant
 CTSGL2 Antibody
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Granzyme K

 Granzyme K ELISA Kit
 Granzyme K Recombinant
 Granzyme K Antibody
GZMK: this protein is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resu
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lting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008]

Protein type: EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide

Molecular Function: serine-type peptidase activity
 Gzmk ELISA Kit
 Gzmk Recombinant
 Gzmk Antibody
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Granzyme M

 Granzyme M ELISA Kit
 Granzyme M Recombinant
 Granzyme M Antibody
Also known as Granzyme M (Met-1 serine protease) (Hu-Met-1) (Met-ase) (Natural killer cell granular protease).
GZMM: Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. Belongs to the peptidase S1 family. Granzy
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me subfamily.

Protein type: EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: membrane

Molecular Function: protein binding; serine-type endopeptidase activity; serine-type peptidase activity

Biological Process: cell death
 GZMM ELISA Kit
 GZMM Recombinant
 GZMM Antibody
 MET1 ELISA Kit
 MET1 Recombinant
 MET1 Antibody
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Proteins Root Name Listing
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