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Growth/differentiation factor

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Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway .

Below are the list of possible Growth/differentiation factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Growth/differentiation factor 10

 Growth/differentiation factor 10 ELISA Kit
 Growth/differentiation factor 10 Recombinant
 Growth/differentiation factor 10 Antibody
Also known as Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B).
GDF10: is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family ar
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e regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that plays a role in skeletal morphogenesis. [provided by RefSeq, Jul 2008]

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: cytokine activity; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; cell development; fat cell differentiation; negative regulation of osteoblast differentiation; positive regulation of osteoblast differentiation; regulation of apoptosis; regulation of MAPKKK cascade
 Gdf10 ELISA Kit
 Gdf10 Recombinant
 Gdf10 Antibody
 Bmp3b ELISA Kit
 Bmp3b Recombinant
 Bmp3b Antibody
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Growth/differentiation factor 11

 Growth/differentiation factor 11 ELISA Kit
 Growth/differentiation factor 11 Recombinant
 Growth/differentiation factor 11 Antibody
Also known as Growth/differentiation factor 11 (GDF-11) (Bone morphogenetic protein 11) (BMP-11).
GDF11: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Belongs to the TGF-beta family.

Protein type: Secreted
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; Secreted, signal peptide

Cellular Component: extracellular space; intracellular membrane-bound organelle; nucleoplasm; protein complex

Molecular Function: cytokine activity; protein binding; transforming growth factor beta receptor binding

Biological Process: anterior/posterior pattern formation; camera-type eye morphogenesis; cell maturation; metanephros development; negative regulation of cell differentiation; negative regulation of cell proliferation; negative regulation of neuron differentiation; organ morphogenesis; palate development; pancreas development; regulation of apoptosis; regulation of MAPKKK cascade; skeletal development; spinal cord anterior/posterior patterning; ureteric bud development
 Gdf11 ELISA Kit
 Gdf11 Recombinant
 Gdf11 Antibody
 Bmp11 ELISA Kit
 Bmp11 Recombinant
 Bmp11 Antibody
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Growth/differentiation factor 15

 Growth/differentiation factor 15 ELISA Kit
 Growth/differentiation factor 15 Recombinant
 Growth/differentiation factor 15 Antibody
Also known as Growth/differentiation factor 15 (GDF-15).
GDF15: disulfide-linked. Belongs to the TGF-beta family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Cellular Component: cytoplasm; extracellular space; nucleus

Molecular Function: cytokine activity; transforming growth factor beta receptor binding

Biological Process: cell development; regulation
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of apoptosis; regulation of MAPKKK cascade
 Gdf15 ELISA Kit
 Gdf15 Recombinant
 Gdf15 Antibody
 Sbf ELISA Kit
 Sbf Recombinant
 Sbf Antibody
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Growth/differentiation factor 2

 Growth/differentiation factor 2 ELISA Kit
 Growth/differentiation factor 2 Recombinant
 Growth/differentiation factor 2 Antibody
Also known as Growth/differentiation factor 2 (GDF-2) (Bone morphogenetic protein 9) (BMP-9).
Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG ().
 gdf2 ELISA Kit
 gdf2 Recombinant
 gdf2 Antibody
 bmp9 ELISA Kit
 bmp9 Recombinant
 bmp9 Antibody
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Growth/differentiation factor 3

 Growth/differentiation factor 3 ELISA Kit
 Growth/differentiation factor 3 Recombinant
 Growth/differentiation factor 3 Antibody
Also known as Growth/differentiation factor 3 (GDF-3).
GDF3: Defects in GDF3 are the cause of Klippel-Feil syndrome type 3 (KFS3); also called Klippel-Feil syndrome autosomal dominant 3. KFS3 is a skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical tri
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ad consists of short neck, low posterior hairline, and limited neck movement. Defects in GDF3 are the cause of microphthalmia isolated with coloboma type 6 (MCOPCB6); also called isolated colobomatous microphthalmia 6. MCOPCB6 is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Defects in GDF3 are a cause of microphthalmia isolated type 7 (MCOP7). MCOP7 is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Belongs to the TGF-beta family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12p13.1

Cellular Component: cytoplasm; extracellular space

Molecular Function: cytokine activity; protein kinase binding; transforming growth factor beta receptor binding

Biological Process: cell development; eye development; negative regulation of BMP signaling pathway; negative regulation of epidermal cell differentiation; regulation of apoptosis; regulation of cell fate commitment; regulation of MAPKKK cascade; skeletal development

Disease: Klippel-feil Syndrome 3, Autosomal Dominant; Microphthalmia, Isolated 7; Microphthalmia, Isolated, With Coloboma 6
 GDF3 ELISA Kit
 GDF3 Recombinant
 GDF3 Antibody
 UNQ222/PRO248 ELISA Kit
 UNQ222/PRO248 Recombinant
 UNQ222/PRO248 Antibody
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Growth/differentiation factor 5

 Growth/differentiation factor 5 ELISA Kit
 Growth/differentiation factor 5 Recombinant
 Growth/differentiation factor 5 Antibody
Also known as Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14).
GDF5: a cytokine that is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. These cytokines are characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Binds to bone morphogenetic protein receptors (BMPRs), a family of transmembrane serine/threonine kinases. B
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MPRs are involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B. Defects in GDF5 are the cause of acromesomelic chondrodysplasia Grebe type (AMDG), acromesomelic chondrodysplasia Hunter-Thompson type (AMDH), brachydactyly type C (BDC), Du Pan syndrome (DPS), symphalangism proximal syndrome (SYM1), multiple synostoses syndrome type 2 (SYNS2), and brachydactyly type A2 (BDA2). Genetic variations in GDF5 are associated with susceptibility to osteoarthritis type 5 (OS5). Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: cytokine activity; protein binding; receptor binding; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; cell development; chondrocyte differentiation; embryonic limb morphogenesis; forelimb morphogenesis; hindlimb morphogenesis; negative regulation of chondrocyte differentiation; negative regulation of epithelial cell proliferation; negative regulation of neuron apoptosis; positive regulation of BMP signaling pathway; positive regulation of chondrocyte differentiation; positive regulation of neuron differentiation; regulation of MAPKKK cascade; regulation of multicellular organism growth; SMAD protein nuclear translocation; transmembrane receptor protein serine/threonine kinase signaling pathway
 Gdf5 ELISA Kit
 Gdf5 Recombinant
 Gdf5 Antibody
 Bmp14 ELISA Kit
 Bmp14 Recombinant
 Bmp14 Antibody
 Bp ELISA Kit
 Bp Recombinant
 Bp Antibody
 Gdf-5 ELISA Kit
 Gdf-5 Recombinant
 Gdf-5 Antibody
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Growth/differentiation factor 6

 Growth/differentiation factor 6 ELISA Kit
 Growth/differentiation factor 6 Recombinant
 Growth/differentiation factor 6 Antibody
Also known as Growth/differentiation factor 6 (GDF-6) (Bone morphogenetic protein 13) (BMP-13) (Cartilage-derived morphogenetic protein 2) (CDMP-2).
Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal
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elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal strucutres. Seems to positively regulates differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG. Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38.
 GDF6 ELISA Kit
 GDF6 Recombinant
 GDF6 Antibody
 BMP13 ELISA Kit
 BMP13 Recombinant
 BMP13 Antibody
 CDMP2 ELISA Kit
 CDMP2 Recombinant
 CDMP2 Antibody
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Growth/differentiation factor 6-A

 Growth/differentiation factor 6-A ELISA Kit
 Growth/differentiation factor 6-A Recombinant
 Growth/differentiation factor 6-A Antibody
Also known as Growth/differentiation factor 6-A (GDF-6-A) (Growth differentiation factor 6A) (Protein radar).
Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead fu
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nctions to establish the integrity of the axial vessels during embryonic development. May be involved in maintaining the identity of cells of the dorsal-most neural tube and of at least a subset of neural crest cells.
 gdf6a ELISA Kit
 gdf6a Recombinant
 gdf6a Antibody
 radar ELISA Kit
 radar Recombinant
 radar Antibody
 rdr ELISA Kit
 rdr Recombinant
 rdr Antibody
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Growth/differentiation factor 6-B

 Growth/differentiation factor 6-B ELISA Kit
 Growth/differentiation factor 6-B Recombinant
 Growth/differentiation factor 6-B Antibody
Also known as Growth/differentiation factor 6-B (GDF-6-B) (Growth differentiation factor 6b) (Protein dynamo).
 gdf6b ELISA Kit
 gdf6b Recombinant
 gdf6b Antibody
 dynamo ELISA Kit
 dynamo Recombinant
 dynamo Antibody
 si:ch211-244a23.2 ELISA Kit
 si:ch211-244a23.2 Recombinant
 si:ch211-244a23.2 Antibody
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Growth/differentiation factor 7

 Growth/differentiation factor 7 ELISA Kit
 Growth/differentiation factor 7 Recombinant
 Growth/differentiation factor 7 Antibody
Also known as Growth/differentiation factor 7 (GDF-7).
GDF7: May play an active role in the motor area of the primate neocortex. Belongs to the TGF-beta family.

Protein type: Cell development/differentiation; Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p24.1

Cellular Component: extracellular space

Molecular Function: cytokine
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activity; protein binding; transforming growth factor beta receptor binding

Biological Process: activin receptor signaling pathway; BMP signaling pathway; cell development; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade
 GDF7 ELISA Kit
 GDF7 Recombinant
 GDF7 Antibody
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Growth/differentiation factor 8

 Growth/differentiation factor 8 ELISA Kit
 Growth/differentiation factor 8 Recombinant
 Growth/differentiation factor 8 Antibody
Also known as Growth/differentiation factor 8 (GDF-8) (Myostatin).
Acts specifically as a negative regulator of skeletal muscle growth.
 MSTN ELISA Kit
 MSTN Recombinant
 MSTN Antibody
 GDF8 ELISA Kit
 GDF8 Recombinant
 GDF8 Antibody
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Growth/differentiation factor 9

 Growth/differentiation factor 9 ELISA Kit
 Growth/differentiation factor 9 Recombinant
 Growth/differentiation factor 9 Antibody
Also known as Growth/differentiation factor 9 (GDF-9).
Required for ovarian folliculogenesis.
 GDF9 ELISA Kit
 GDF9 Recombinant
 GDF9 Antibody
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