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Growth factor receptor-bound protein

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Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. A similar role in the mediation of ubiquitination has also been suggested with INSR. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2 (By similarity).

Below are the list of possible Growth factor receptor-bound protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Growth factor receptor-bound protein 10

 Growth factor receptor-bound protein 10 ELISA Kit
 Growth factor receptor-bound protein 10 Recombinant
 Growth factor receptor-bound protein 10 Antibody
Also known as Growth factor receptor-bound protein 10 (GRB10 adapter protein).
GRB10: an adaptor protein that inhibits insulin-stimulated IRS-PI (3)K-Akt signaling pathway by disrupting the association of IRS with the insulin receptor. Also binds activated PDGFR and EGFR. Preferentially localizes to the mitochondria, modulating the anti-apoptotic activity of mitochondrial Raf-1. Can translocate
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to the plasma membrane and lamellipodia. Three alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold

Molecular Function: insulin receptor binding; SH3/SH2 adaptor activity

Biological Process: insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; negative regulation of glucose import; negative regulation of glycogen biosynthetic process; negative regulation of insulin receptor signaling pathway; negative regulation of phosphorylation; negative regulation of Wnt receptor signaling pathway; positive regulation of phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; response to insulin stimulus
 Grb10 ELISA Kit
 Grb10 Recombinant
 Grb10 Antibody
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Growth factor receptor-bound protein 14

 Growth factor receptor-bound protein 14 ELISA Kit
 Growth factor receptor-bound protein 14 Recombinant
 Growth factor receptor-bound protein 14 Antibody
Also known as Growth factor receptor-bound protein 14 (GRB14 adapter protein).
GRB14: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation i
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n response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. Belongs to the GRB7/10/14 family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2q22-q24

Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; plasma membrane

Biological Process: leukocyte migration
 GRB14 ELISA Kit
 GRB14 Recombinant
 GRB14 Antibody
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Growth factor receptor-bound protein 2

 Growth factor receptor-bound protein 2 ELISA Kit
 Growth factor receptor-bound protein 2 Recombinant
 Growth factor receptor-bound protein 2 Antibody
Also known as Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2).
GRB2: an adaptor protein of the GRB2 / sem-5 / DRK family. Associates with many different tyrosine-phosphorylated proteins via its SH2 domain, including EGFR, PDGFR, IRS-1, SHC and LNK. It also seems to interact with RAS in the signaling pathway leading to DNA synthesis. Binds to a
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nd translocates the guanine nucleotide exchange factors SOS. Four alternatively spliced isoforms have been described. Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.

Protein type: Adaptor/scaffold; Cell development/differentiation; Motility/polarity/chemotaxis

Cellular Component: cytoplasm; cytosol; endosome; intercellular junction; membrane; nucleolus; nucleoplasm; nucleus; plasma membrane; protein complex; signalosome; vesicle membrane

Molecular Function: enzyme binding; ephrin receptor binding; epidermal growth factor receptor binding; identical protein binding; insulin receptor substrate binding; neurotrophin TRKA receptor binding; phosphoprotein binding; phosphotyrosine binding; protein binding; protein domain specific binding; protein kinase binding; protein phosphatase binding; SH3 domain binding; SH3/SH2 adaptor activity

Biological Process: aging; anatomical structure formation; cell differentiation; DNA damage response, signal transduction; fibroblast growth factor receptor signaling pathway; insulin receptor signaling pathway; positive regulation of actin filament polymerization; protein heterooligomerization; Ras protein signal transduction; receptor internalization; regulation of MAPKKK cascade
 Grb2 ELISA Kit
 Grb2 Recombinant
 Grb2 Antibody
 Ash ELISA Kit
 Ash Recombinant
 Ash Antibody
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Growth factor receptor-bound protein 2-A

 Growth factor receptor-bound protein 2-A ELISA Kit
 Growth factor receptor-bound protein 2-A Recombinant
 Growth factor receptor-bound protein 2-A Antibody
Also known as Growth factor receptor-bound protein 2-A (Adapter protein GRB2-A) (SH2/SH3 adapter GRB2-A).
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway (). Promotes meiotic reinitiation during oocyte maturation.
 grb2-a ELISA Kit
 grb2-a Recombinant
 grb2-a Antibody
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Growth factor receptor-bound protein 2-B

 Growth factor receptor-bound protein 2-B ELISA Kit
 Growth factor receptor-bound protein 2-B Recombinant
 Growth factor receptor-bound protein 2-B Antibody
Also known as Growth factor receptor-bound protein 2-B (Adapter protein GRB2-B) (SH2/SH3 adapter GRB2-B).
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway (). Promotes meiotic reinitiation during oocyte maturation.
 grb2-b ELISA Kit
 grb2-b Recombinant
 grb2-b Antibody
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Growth factor receptor-bound protein 7

 Growth factor receptor-bound protein 7 ELISA Kit
 Growth factor receptor-bound protein 7 Recombinant
 Growth factor receptor-bound protein 7 Antibody
Also known as Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein).
GRB7: Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in si
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gnal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress. Homodimer. Interacts (via SH2 domain) with EGFR, ERBB2, ERBB3 (when phosphorylated), ERBB4 (when phosphorylated), EPHB1, INSR, FGFR1, PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Interacts with SHC1. Interacts with RND1. Interacts (when tyrosine phosphorylated) with FHL2 and HAX1. Interacts (via SH2 domain) with RET and PTK2/FAK1. Interacts (when not phosphorylated) with ELAVL1. In stressed cells, but not in normal cells, part of a complex that contains at least GRB7, PTK2/FAK1, STAU1, ELAVL1 and TIA1. Interacts (via SH2 domain) with KIT (phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated). Belongs to the GRB7/10/14 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: cytosol; focal adhesion; stress granule

Molecular Function: identical protein binding; phosphoinositide binding; protein binding; protein kinase binding; SH3/SH2 adaptor activity

Biological Process: epidermal growth factor receptor signaling pathway; leukocyte migration; negative regulation of translation; positive regulation of cell migration; stress granule assembly
 GRB7 ELISA Kit
 GRB7 Recombinant
 GRB7 Antibody
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