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H-2 class II histocompatibility antigen

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Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.

Below are the list of possible H-2 class II histocompatibility antigen products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

H-2 class II histocompatibility antigen gamma chain

 H-2 class II histocompatibility antigen gamma chain ELISA Kit
 H-2 class II histocompatibility antigen gamma chain Recombinant
 H-2 class II histocompatibility antigen gamma chain Antibody
Also known as H-2 class II histocompatibility antigen gamma chain (Ia antigen-associated invariant chain) (Ii) (MHC class II-associated invariant chain) (CD antigen CD74).
CD74: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic r
>>>
eticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74- ROS1 chimeric protein. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Membrane protein, integral; Receptor, cytokine

Cellular Component: cell surface; endoplasmic reticulum; external side of plasma membrane; Golgi apparatus; integral to membrane; late endosome; lysosome; membrane; MHC class II protein complex; multivesicular body; plasma membrane; vacuole

Molecular Function: beta-amyloid binding; cytokine binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; MHC class II protein binding; MHC class II protein binding, via antigen binding groove; nitric-oxide synthase binding

Biological Process: activation of MAPK activity; antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; cell proliferation; chaperone cofactor-dependent protein folding; defense response; immunoglobulin mediated immune response; intracellular protein transport; negative regulation of apoptosis; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of mature B cell apoptosis; negative regulation of peptide secretion; negative regulation of T cell differentiation; negative thymic T cell selection; positive regulation of B cell proliferation; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of dendritic cell antigen processing and presentation; positive regulation of fibroblast proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell differentiation; positive regulation of T-helper 2 type immune response; positive thymic T cell selection; prostaglandin biosynthetic process; protein complex assembly; signal transduction
 Cd74 ELISA Kit
 Cd74 Recombinant
 Cd74 Antibody
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H-2 class II histocompatibility antigen, A beta chain

 H-2 class II histocompatibility antigen, A beta chain ELISA Kit
 H-2 class II histocompatibility antigen, A beta chain Recombinant
 H-2 class II histocompatibility antigen, A beta chain Antibody
 H2-Ab1 ELISA Kit
 H2-Ab1 Recombinant
 H2-Ab1 Antibody
 H2-iabeta ELISA Kit
 H2-iabeta Recombinant
 H2-iabeta Antibody
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H-2 class II histocompatibility antigen, A-B alpha chain

 H-2 class II histocompatibility antigen, A-B alpha chain ELISA Kit
 H-2 class II histocompatibility antigen, A-B alpha chain Recombinant
 H-2 class II histocompatibility antigen, A-B alpha chain Antibody
Also known as H-2 class II histocompatibility antigen, A-B alpha chain (IAalpha).
 H2-Aa ELISA Kit
 H2-Aa Recombinant
 H2-Aa Antibody
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H-2 class II histocompatibility antigen, A-D alpha chain

 H-2 class II histocompatibility antigen, A-D alpha chain ELISA Kit
 H-2 class II histocompatibility antigen, A-D alpha chain Recombinant
 H-2 class II histocompatibility antigen, A-D alpha chain Antibody
 H2-Aa ELISA Kit
 H2-Aa Recombinant
 H2-Aa Antibody
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H-2 class II histocompatibility antigen, A-D beta chain

 H-2 class II histocompatibility antigen, A-D beta chain ELISA Kit
 H-2 class II histocompatibility antigen, A-D beta chain Recombinant
 H-2 class II histocompatibility antigen, A-D beta chain Antibody
 H2-Ab1 ELISA Kit
 H2-Ab1 Recombinant
 H2-Ab1 Antibody
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H-2 class II histocompatibility antigen, A-F alpha chain

 H-2 class II histocompatibility antigen, A-F alpha chain ELISA Kit
 H-2 class II histocompatibility antigen, A-F alpha chain Recombinant
 H-2 class II histocompatibility antigen, A-F alpha chain Antibody
HLA-DQA1: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are p
>>>
rocessed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. Belongs to the MHC class II family. {ECO:0000305}. Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides. {ECO:0000269|PubMed:11376336, ECO:0000269|PubMed:14769912, ECO:0000269|PubMed:15020763, ECO:0000269|PubMed:17629515}

Protein type: Cell surface; Membrane protein, integral

Cellular Component: external side of plasma membrane; lysosome; membrane; MHC class II protein complex; plasma membrane

Molecular Function: peptide antigen binding; protein binding; protein heterodimerization activity

Biological Process: antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen; negative regulation of T cell proliferation; positive regulation of T cell differentiation
 H2-Aa ELISA Kit
 H2-Aa Recombinant
 H2-Aa Antibody
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H-2 class II histocompatibility antigen, A-F beta chain

 H-2 class II histocompatibility antigen, A-F beta chain ELISA Kit
 H-2 class II histocompatibility antigen, A-F beta chain Recombinant
 H-2 class II histocompatibility antigen, A-F beta chain Antibody
 H2-Ab1 ELISA Kit
 H2-Ab1 Recombinant
 H2-Ab1 Antibody
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H-2 class II histocompatibility antigen, A-K alpha chain

 H-2 class II histocompatibility antigen, A-K alpha chain ELISA Kit
 H-2 class II histocompatibility antigen, A-K alpha chain Recombinant
 H-2 class II histocompatibility antigen, A-K alpha chain Antibody
 H2-Aa ELISA Kit
 H2-Aa Recombinant
 H2-Aa Antibody
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H-2 class II histocompatibility antigen, A-K beta chain

 H-2 class II histocompatibility antigen, A-K beta chain ELISA Kit
 H-2 class II histocompatibility antigen, A-K beta chain Recombinant
 H-2 class II histocompatibility antigen, A-K beta chain Antibody
 H2-Ab1 ELISA Kit
 H2-Ab1 Recombinant
 H2-Ab1 Antibody
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H-2 class II histocompatibility antigen, A-Q alpha chain

 H-2 class II histocompatibility antigen, A-Q alpha chain ELISA Kit
 H-2 class II histocompatibility antigen, A-Q alpha chain Recombinant
 H-2 class II histocompatibility antigen, A-Q alpha chain Antibody
 H2-Aa ELISA Kit
 H2-Aa Recombinant
 H2-Aa Antibody
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H-2 class II histocompatibility antigen, A-Q beta chain

 H-2 class II histocompatibility antigen, A-Q beta chain ELISA Kit
 H-2 class II histocompatibility antigen, A-Q beta chain Recombinant
 H-2 class II histocompatibility antigen, A-Q beta chain Antibody
HLA-DQB1: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are p
>>>
rocessed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. Belongs to the MHC class II family.

Protein type: Membrane protein, integral

Cellular Component: cell surface; early endosome; external side of plasma membrane; Golgi apparatus; integral to membrane; intracellular; membrane; MHC class II protein complex; multivesicular body; plasma membrane

Molecular Function: peptide antigen binding; protein binding; protein heterodimerization activity; toxin binding; transcription factor binding; ubiquitin protein ligase binding

Biological Process: antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen; B cell affinity maturation; humoral immune response mediated by circulating immunoglobulin; immune response; immunoglobulin production during immune response; negative regulation of T cell proliferation; positive regulation of alpha-beta T cell activation; positive regulation of antigen processing and presentation; positive regulation of T-helper 1 type immune response
 H2-Ab1 ELISA Kit
 H2-Ab1 Recombinant
 H2-Ab1 Antibody
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H-2 class II histocompatibility antigen, A-R alpha chain

 H-2 class II histocompatibility antigen, A-R alpha chain ELISA Kit
 H-2 class II histocompatibility antigen, A-R alpha chain Recombinant
 H-2 class II histocompatibility antigen, A-R alpha chain Antibody
 H2-Aa ELISA Kit
 H2-Aa Recombinant
 H2-Aa Antibody
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H-2 class II histocompatibility antigen, A-S alpha chain

 H-2 class II histocompatibility antigen, A-S alpha chain ELISA Kit
 H-2 class II histocompatibility antigen, A-S alpha chain Recombinant
 H-2 class II histocompatibility antigen, A-S alpha chain Antibody
 H2-Aa ELISA Kit
 H2-Aa Recombinant
 H2-Aa Antibody
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H-2 class II histocompatibility antigen, A-S beta chain

 H-2 class II histocompatibility antigen, A-S beta chain ELISA Kit
 H-2 class II histocompatibility antigen, A-S beta chain Recombinant
 H-2 class II histocompatibility antigen, A-S beta chain Antibody
 H2-Ab1 ELISA Kit
 H2-Ab1 Recombinant
 H2-Ab1 Antibody
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H-2 class II histocompatibility antigen, A-U alpha chain

 H-2 class II histocompatibility antigen, A-U alpha chain ELISA Kit
 H-2 class II histocompatibility antigen, A-U alpha chain Recombinant
 H-2 class II histocompatibility antigen, A-U alpha chain Antibody
 H2-Aa ELISA Kit
 H2-Aa Recombinant
 H2-Aa Antibody
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H-2 class II histocompatibility antigen, A-U beta chain

 H-2 class II histocompatibility antigen, A-U beta chain ELISA Kit
 H-2 class II histocompatibility antigen, A-U beta chain Recombinant
 H-2 class II histocompatibility antigen, A-U beta chain Antibody
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H-2 class II histocompatibility antigen, E-B beta chain

 H-2 class II histocompatibility antigen, E-B beta chain ELISA Kit
 H-2 class II histocompatibility antigen, E-B beta chain Recombinant
 H-2 class II histocompatibility antigen, E-B beta chain Antibody
 H2-Eb1 ELISA Kit
 H2-Eb1 Recombinant
 H2-Eb1 Antibody
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H-2 class II histocompatibility antigen, E-D alpha chain

 H-2 class II histocompatibility antigen, E-D alpha chain ELISA Kit
 H-2 class II histocompatibility antigen, E-D alpha chain Recombinant
 H-2 class II histocompatibility antigen, E-D alpha chain Antibody
Also known as H-2 class II histocompatibility antigen, E-D alpha chain (H2-IE-alpha).
This locus belongs to the class II major histocompatibility complex (MHC) family of genes, which encode immune response (Ia) antigens that function in the T-cell-dependent immune response. This family member has multiple haplotypes, some of which result in the production of an E-alpha subunit that combines wit
>>>
h an E-beta subunit to form a functional E complex at the cell surface. Other haplotypes, including that of the reference genome allele, contain mutations and they thus represent polymorphic pseudogenes that do not produce functional products. These mutations include frameshifting indels, nonsense mutations, and deletions of larger regions. The reference genome haplotype contains a deletion at the 5' end of the gene, including the core promoter region and the transcription start site, and therefore no transcripts result from this haplotype. [provided by RefSeq, Aug 2011]
 H2-Ea ELISA Kit
 H2-Ea Recombinant
 H2-Ea Antibody
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H-2 class II histocompatibility antigen, E-D beta chain

 H-2 class II histocompatibility antigen, E-D beta chain ELISA Kit
 H-2 class II histocompatibility antigen, E-D beta chain Recombinant
 H-2 class II histocompatibility antigen, E-D beta chain Antibody
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H-2 class II histocompatibility antigen, E-K alpha chain

 H-2 class II histocompatibility antigen, E-K alpha chain ELISA Kit
 H-2 class II histocompatibility antigen, E-K alpha chain Recombinant
 H-2 class II histocompatibility antigen, E-K alpha chain Antibody
This locus belongs to the class II major histocompatibility complex (MHC) family of genes, which encode immune response (Ia) antigens that function in the T-cell-dependent immune response. This family
>>>
member has multiple haplotypes, some of which result in the production of an E-alpha subunit that combines with an E-beta subunit to form a functional E complex at the cell surface. Other haplotypes, including that of the reference genome allele, contain mutations and they thus represent polymorphic pseudogenes that do not produce functional products. These mutations include frameshifting indels, nonsense mutations, and deletions of larger regions. The reference genome haplotype contains a deletion at the 5' end of the gene, including the core promoter region and the transcription start site, and therefore no transcripts result from this haplotype. [provided by RefSeq, Aug 2011]
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H-2 class II histocompatibility antigen, E-Q beta chain

 H-2 class II histocompatibility antigen, E-Q beta chain ELISA Kit
 H-2 class II histocompatibility antigen, E-Q beta chain Recombinant
 H-2 class II histocompatibility antigen, E-Q beta chain Antibody
Also known as H-2 class II histocompatibility antigen, E-Q beta chain (E-W17).
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H-2 class II histocompatibility antigen, E-S beta chain

 H-2 class II histocompatibility antigen, E-S beta chain ELISA Kit
 H-2 class II histocompatibility antigen, E-S beta chain Recombinant
 H-2 class II histocompatibility antigen, E-S beta chain Antibody
 H2-Eb1 ELISA Kit
 H2-Eb1 Recombinant
 H2-Eb1 Antibody
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H-2 class II histocompatibility antigen, E-U alpha chain

 H-2 class II histocompatibility antigen, E-U alpha chain ELISA Kit
 H-2 class II histocompatibility antigen, E-U alpha chain Recombinant
 H-2 class II histocompatibility antigen, E-U alpha chain Antibody
This locus belongs to the class II major histocompatibility complex (MHC) family of genes, which encode immune response (Ia) antigens that function in the T-cell-dependent immune response. This family member has multiple haplotypes, some of which result in the production of an E-alpha subunit that combines with an E-beta subunit to form a functional E complex at the cell surface. Other haplotypes,
>>>
including that of the reference genome allele, contain mutations and they thus represent polymorphic pseudogenes that do not produce functional products. These mutations include frameshifting indels, nonsense mutations, and deletions of larger regions. The reference genome haplotype contains a deletion at the 5' end of the gene, including the core promoter region and the transcription start site, and therefore no transcripts result from this haplotype. [provided by RefSeq, Aug 2011]
 H2-Ea ELISA Kit
 H2-Ea Recombinant
 H2-Ea Antibody
 H2-Ea-ps ELISA Kit
 H2-Ea-ps Recombinant
 H2-Ea-ps Antibody
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H-2 class II histocompatibility antigen, I-A beta chain

 H-2 class II histocompatibility antigen, I-A beta chain ELISA Kit
 H-2 class II histocompatibility antigen, I-A beta chain Recombinant
 H-2 class II histocompatibility antigen, I-A beta chain Antibody
HLA-DRB1: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are p
>>>
rocessed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and efficient peptide loading. Genetic variation in HLA-DRB1 is a cause of susceptibility to sarcoidosis type 1 (SS1). Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Belongs to the MHC class II family.

Protein type: Membrane protein, integral

Cellular Component: late endosome membrane; lysosomal membrane; MHC class II protein complex

Molecular Function: protein binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II
 H2-Eb1 ELISA Kit
 H2-Eb1 Recombinant
 H2-Eb1 Antibody
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H-2 class II histocompatibility antigen, I-E alpha chain

 H-2 class II histocompatibility antigen, I-E alpha chain ELISA Kit
 H-2 class II histocompatibility antigen, I-E alpha chain Recombinant
 H-2 class II histocompatibility antigen, I-E alpha chain Antibody
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H-2 class II histocompatibility antigen, I-E beta chain

 H-2 class II histocompatibility antigen, I-E beta chain ELISA Kit
 H-2 class II histocompatibility antigen, I-E beta chain Recombinant
 H-2 class II histocompatibility antigen, I-E beta chain Antibody
 H2-Eb1 ELISA Kit
 H2-Eb1 Recombinant
 H2-Eb1 Antibody
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