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In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).

Below are the list of possible Hamartin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.


 Hamartin ELISA Kit
 Hamartin Recombinant
 Hamartin Antibody
Also known as Hamartin (Tuberous sclerosis 1 protein homolog).
TSC1: tuberous sclerosis protein 1 (TSC1). May have tumor suppressor activity. Together with tuberin (TSC2), inhibits mammalian target of rapamycin (mTOR)-mediated signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase. Regulated by the phosphatidylinositol 3-kinase/Akt pathway and ph
osphorylation of tuberin. Phosphorylated by cyclin-dependent kinase 1/cyclin B during the cell cycle.

Protein type: Motility/polarity/chemotaxis; Tumor suppressor

Cellular Component: actin filament; cell cortex; cytoplasm; cytoskeleton; cytosol; growth cone; intracellular membrane-bound organelle; lamellipodium; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; TSC1-TSC2 complex

Molecular Function: chaperone binding; GTPase activating protein binding; GTPase regulator activity; protein binding; protein N-terminus binding

Biological Process: adaptive immune response; adult locomotory behavior; cardiac muscle cell differentiation; cell projection organization and biogenesis; cell-matrix adhesion; cerebral cortex development; embryonic development; glucose import; hippocampus development; kidney development; memory T cell differentiation; myelination; negative regulation of cell proliferation; negative regulation of cell size; negative regulation of insulin receptor signaling pathway; negative regulation of macroautophagy; negative regulation of TOR signaling pathway; negative regulation of translation; nervous system development; neural tube closure; positive regulation of focal adhesion formation; potassium ion transport; protein heterooligomerization; protein stabilization; regulation of actin cytoskeleton organization and biogenesis; regulation of cell cycle; regulation of cell-matrix adhesion; regulation of focal adhesion formation; regulation of GTPase activity; regulation of phosphoprotein phosphatase activity; regulation of protein kinase activity; regulation of stress fiber formation; regulation of translation; response to insulin stimulus; rRNA export from nucleus; synapse organization and biogenesis
 Tsc1 ELISA Kit
 Tsc1 Recombinant
 Tsc1 Antibody
 Kiaa0243 ELISA Kit
 Kiaa0243 Recombinant
 Kiaa0243 Antibody
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