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Haptoglobin

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As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).

Below are the list of possible Haptoglobin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Haptoglobin

 Haptoglobin ELISA Kit
 Haptoglobin Recombinant
 Haptoglobin Antibody
Also known as Haptoglobin (Liver regeneration-related protein LRRG173) (Zonulin).
HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting th
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e kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family.

Protein type: Endoplasmic reticulum; Secreted; Secreted, signal peptide

Cellular Component: endoplasmic reticulum; extracellular space; Golgi apparatus

Molecular Function: hemoglobin binding; protein homodimerization activity

Biological Process: acute inflammatory response; aging; liver development; negative regulation of oxidoreductase activity; Notch signaling pathway; organ regeneration; response to cobalamin; response to drug; response to electrical stimulus; response to glucocorticoid stimulus; response to heat; response to hydrogen peroxide; response to hypoxia; response to L-ascorbic acid; response to lead ion; response to lipopolysaccharide; response to magnesium ion; response to organic cyclic substance; response to organic substance; response to starvation; response to X-ray; spermatogenesis
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