| Haptoglobin ELISA Kit|
|Also known as Haptoglobin (Liver regeneration-related protein LRRG173) (Zonulin). |
HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting th
e kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family.
Protein type: Endoplasmic reticulum; Secreted; Secreted, signal peptide
Cellular Component: endoplasmic reticulum; extracellular space; Golgi apparatus
Molecular Function: hemoglobin binding; protein homodimerization activity
Biological Process: acute inflammatory response; aging; liver development; negative regulation of oxidoreductase activity; Notch signaling pathway; organ regeneration; response to cobalamin; response to drug; response to electrical stimulus; response to glucocorticoid stimulus; response to heat; response to hydrogen peroxide; response to hypoxia; response to L-ascorbic acid; response to lead ion; response to lipopolysaccharide; response to magnesium ion; response to organic cyclic substance; response to organic substance; response to starvation; response to X-ray; spermatogenesis