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Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.

Below are the list of possible Hemojuvelin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.


 Hemojuvelin ELISA Kit
 Hemojuvelin Recombinant
 Hemojuvelin Antibody
Also known as Hemojuvelin (Hemochromatosis type 2 protein homolog) (RGM domain family member C).
HFE2: Member of the repulsive guidance molecule (RGM) family. Involved in iron metabolism. Acts as a bone morphogenetic protein (BMP) coreceptor. Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism. May cooperate with hepcidin to restrict iron absorption in the gut.
Could represent the cellular receptor for hepcidin. Defects in HFE2 are the cause of hemochromatosis type 2A (HFE2A); also known as juvenile hemochromatosis (JH). HFE2A is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. It is the consequence of intestinal iron hyperabsorption associated with macrophages that do not load iron. Deleterious mutations of HFE2 reduced HAMP (hepcidin) levels despite iron overload, which normally induces HAMP expression. Belongs to the repulsive guidance molecule (RGM) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor

Cellular Component: basolateral plasma membrane; cell surface; extracellular space; plasma membrane

Molecular Function: coreceptor activity; glycoprotein binding; receptor binding

Biological Process: activin receptor signaling pathway; BMP signaling pathway; cellular iron ion homeostasis; iron ion homeostasis; negative regulation of BMP signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; protein autoprocessing
 Hfe2 ELISA Kit
 Hfe2 Recombinant
 Hfe2 Antibody
 Rgmc ELISA Kit
 Rgmc Recombinant
 Rgmc Antibody
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