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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase

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Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes .

Below are the list of possible High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A ELISA Kit
 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A Recombinant
 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A Antibody
PDE8A: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein ty
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pe: EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase

Chromosomal Location of Human Ortholog: 15q25.3

Cellular Component: cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; kinase binding

Biological Process: positive regulation of protein amino acid phosphorylation
 PDE8A ELISA Kit
 PDE8A Recombinant
 PDE8A Antibody
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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B ELISA Kit
 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B Recombinant
 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B Antibody
Also known as High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (HsPDE8B) (Cell proliferation-inducing gene 22 protein).
PDE8B: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland. Defects in PDE8B are the cause of striatal degeneration autosomal domi
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nant (ADSD). It is a movement disorder affecting the striatal part of the basal ganglia and characterized by bradykinesia, dysarthria and muscle rigidity. These symptoms resemble idiopathic Parkinson disease, but tremor is not present. Defects in PDE8B are the cause of primary pigmented nodular adrenocortical disease type 3 (PPNAD3). PPNAD3 is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. Adrenal glands show overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. Clinical manifestations of Cushing syndrome include facial and trunkal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase

Chromosomal Location of Human Ortholog: 5q13.3

Cellular Component: cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity

Disease: Pigmented Nodular Adrenocortical Disease, Primary, 3; Striatal Degeneration, Autosomal Dominant
 PDE8B ELISA Kit
 PDE8B Recombinant
 PDE8B Antibody
 PIG22 ELISA Kit
 PIG22 Recombinant
 PIG22 Antibody
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