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Highly reducing polyketide synthase

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Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of azaphilones, a class of fungal metabolites characterized by a highly oxygenated pyrano-quinone bicyclic core and exhibiting a broad range of bioactivities .

Below are the list of possible Highly reducing polyketide synthase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Highly reducing polyketide synthase azaB

 Highly reducing polyketide synthase azaB ELISA Kit
 Highly reducing polyketide synthase azaB Recombinant
 Highly reducing polyketide synthase azaB Antibody
Also known as Highly reducing polyketide synthase azaB (HR-PKS azaB) (Azaphilone biosynthesis cluster protein azaB).
Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of azaphilones, a class of fungal metabolites characterized by a highly oxygenated pyrano-quinone bicyclic core and exhibiting a broad range of bioactivities (PubMed:22921072). In the fir
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st step, the non-reducing polyketide synthase azaA forms the hexaketide precursor from successive condensations of five malonyl-CoA units, presumably with a simple acetyl-CoA starter unit (PubMed:22921072). The reactive polyketide chain then undergoes a PT-mediated C2-C7 cyclization to afford the aromatic ring and is eventually released as an aldehyde through the R-domain (PubMed:22921072). The putative ketoreductase azaE is proposed to catalyze the reduction of the terminal ketone resulting in the early culture product FK17-P2a (PubMed:22921072). The monooxygenase azaH was demonstrated to be the only enzyme required to convert FK17-P2a to azanigerone E (PubMed:22921072). AzaH first hydroxylates the benzaldehyde intermediate FK17-P2a at C4, which triggers the formation of the pyran-ring to afford azanigerone E (PubMed:22921072). In parallel, the 2,4-dimethylhexanoyl chain is synthesized by the HR-PKS azaB and is proposed to be transferred to the C4-hydroxyl of azanigerone E by the acyltransferase azaD directly from the ACP domain of azaB (PubMed:22921072). Alternatively, the 2,4-dimethyl-hexanoyl chain may be offloaded from the HR-PKS as a carboxylic acid and converted to an acyl-CoA by azaF (PubMed:22921072). The resulting acyl-CoA molecule could then be taken up as a substrate by AzaD to form azanigerone B (PubMed:22921072). To yield the carboxylic acid substituent in azanigerone A, the hydroxypropyl side chain of azanigerone B would need to undergo a C-C oxidative cleavage catalyzed by cytochrome P450 AzaI (PubMed:22921072). AzaI is proposed to act on a vicinal diol that leads to a C-C bond scission either through an alkoxyradical intermediate or a peroxy complex (PubMed:22921072). In the biosynthesis of azanigerone A, azanigerone B first undergoes hydroxylation at C10, possibly catalyzed by one of the two FAD-dependent monooxygenases encoded in the cluster, azaG or azaL, resulting in the vicinal diol azanigerone C (PubMed:22921072). Oxidative cleavage of azanigerone C by azaI would yield the corresponding aldehyde derivative of azanigerone A (PubMed:22921072). Finally, the dehydrogenase azaJ is proposed to convert the aldehyde functional group into the carboxylic acid, completing the conversion from azanigerone B to azanigerone A (PubMed:22921072). Alternatively, the oxidation of aldehyde to carboxylic acid may be catalyzed by the same P450 enzyme azaI via consecutive oxidation or by endogenous alcohol dehydrogenase (PubMed:22921072).
 azaB ELISA Kit
 azaB Recombinant
 azaB Antibody
 ASPNIDRAFT_188817 ELISA Kit
 ASPNIDRAFT_188817 Recombinant
 ASPNIDRAFT_188817 Antibody
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Highly reducing polyketide synthase cla2

 Highly reducing polyketide synthase cla2 ELISA Kit
 Highly reducing polyketide synthase cla2 Recombinant
 Highly reducing polyketide synthase cla2 Antibody
Also known as Highly reducing polyketide synthase cla2 (Cladosporin bioynthesis cluster protein 2).
Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of cladosporin, a tricyclic octaketide that acts as an antimalarial agent though inhibition of the Plasmodium falciparum lysyl-tRNA synthetase (PubMed:26783060). The highly reducing polyketide synthase cl
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a2 is responsible for biosynthesis up to the pentaketide stage, including of the tetrahydropyran (THP) ring, whereas the three subsequent ketide extensions with no reduction are catalyzed by the non-reducing polyketide synthase cla3 (PubMed:26783060).
 cla2 ELISA Kit
 cla2 Recombinant
 cla2 Antibody
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Highly reducing polyketide synthase ctvA

 Highly reducing polyketide synthase ctvA ELISA Kit
 Highly reducing polyketide synthase ctvA Recombinant
 Highly reducing polyketide synthase ctvA Antibody
Also known as Highly reducing polyketide synthase ctvA (HR-PKS ctvA) (Citreoviridin biosynthesis protein A).
Highly reducing polyketide synthase (HR-PKS); part of the gene cluster that mediates the biosynthesis of citreoviridin, an inhibitor of the of F1-ATPase beta-subunit (PubMed:26954888). The HR-PKS ctvA accepts acetyl-CoA as the starter unit and catalyzes eight iterations of malonyl-CoA ex
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tension and four iterations of SAM-dependent methylation at C4, C12, C14, and C16 (PubMed:26954888). The KR and DH domains selectively act on the first six iterations to generate the hexaene chain (PubMed:26954888). In the last three iterations, the KR and DH domains terminate their functions to yield a beta,delta-diketo ester moiety, which then undergoes intramolecular cyclization to yield an alpha-pyrone intermediate (PubMed:26954888). Subsequently, ctvB methylates the alpha-pyrone hydroxyl group to generate citreomontanin (PubMed:26954888). In order to form the tetrahydrofuran ring with the correct stereochemistry, the terminal alkenes of citreomontanin need to undergo isomerization to yield a (17Z)-hexaene, a step that could be catalyzed by ctvC (PubMed:26954888). The (17Z)-hexaene then undergoes bisepoxidation by ctvC to form a (17R,16R,15S,14R)-bisepoxide moiety (PubMed:26954888). Lastly, ctvD acts as a regioselective hydrolase to form the tetrahydrofuran ring with the substituents in the correct absolute configuration, completing the biosynthesis of citreoviridin (PubMed:26954888).
 ctvA ELISA Kit
 ctvA Recombinant
 ctvA Antibody
 ATEG_09617 ELISA Kit
 ATEG_09617 Recombinant
 ATEG_09617 Antibody
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