Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Protein Family  rightarrow Histone lysine demethylase  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Virulence plasmid ParA family protein pGP5-D (pCHL1p7) Recombinant Protein
 • Nucleoporin 37Kda (NUP37) ELISA Kit
 • 50S ribosomal protein L11 (rplK) Recombinant Protein
 • MAGEA2 Antibody
 • CALR3 cDNA Clone
 • Zinc Finger Homeobox Protein 3 (ZFHX3) ELISA Kit
 • Hainantoxin-XVI.5 (HNTX-XVI.5) Recombinant Protein
 • GLI Family Zinc Finger Protein 1 (GLI1) ELISA Kit
 • sAC ELISA Kit
 • 39S ribosomal protein L39, mitochondrial (mRpL39) Recombinant Protein
 • Malonyl-CoA-acyl carrier protein transacylase, mitochondrial... ELISA Kit
 • Chlamydial protease-like activity factor (CPAF) ELISA Kit
 • J domain-containing protein APJ1 (APJ1), partial Recombinant Protein
 • 26S proteasome non-ATPase regulatory subunit 2 (PSMD2) ELISA Kit
 downarrow more ...
separator

Histone lysine demethylase

separator
Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3 (By similarity).

Below are the list of possible Histone lysine demethylase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Histone lysine demethylase PHF8

 Histone lysine demethylase PHF8 ELISA Kit
 Histone lysine demethylase PHF8 Recombinant
 Histone lysine demethylase PHF8 Antibody
Also known as Histone lysine demethylase PHF8 (PHD finger protein 8).
PHF8: a PHD finger protein with N(epsilon)-methyl lysine histone demethylase activity. Associated with mental retardation and cleft lip/palate. Its active site is closely related to those of FBXL10 and 11, all of which are selective for di- and mono-methylated lysine. In contrast, the JMJD2 demethylases are selective for tri
>>>
- and di-methylated lysine.

Protein type: Demethylase; EC 1.14.11.27; Nucleolus

Cellular Component: nuclear membrane; nucleolus; nucleus

Molecular Function: chromatin binding; histone demethylase activity; histone demethylase activity (H3-K36 specific); histone demethylase activity (H3-K9 specific); iron ion binding; methylated histone residue binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; zinc ion binding

Biological Process: G1/S transition of mitotic cell cycle; histone H3-K9 demethylation; positive regulation of transcription from RNA polymerase I promoter; positive regulation of transcription, DNA-dependent
 Phf8 ELISA Kit
 Phf8 Recombinant
 Phf8 Antibody
 Kiaa1111 ELISA Kit
 Kiaa1111 Recombinant
 Kiaa1111 Antibody
Table BarTOPTable Bar
Proteins Root Name Listing
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions