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Histone-lysine N-methyltransferase

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Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer. Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity).

Below are the list of possible Histone-lysine N-methyltransferase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Histone-lysine N-methyltransferase 2A

 Histone-lysine N-methyltransferase 2A ELISA Kit
 Histone-lysine N-methyltransferase 2A Recombinant
 Histone-lysine N-methyltransferase 2A Antibody
Also known as Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (ALL-1) (CXXC-type zinc finger protein 7) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zin.
MLL: Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediate
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s H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. Chromosomal aberrations involving MLL are a cause of acute leukemias. Translocation t(1;11)(q21;q23) with MLLT11/AF1Q; translocation t(3;11)(p21;q23) with NCKIPSD/AF3p21; translocation t(3,11)(q25,q23) with GMPS; translocation t(4;11)(q21;q23) with AFF1/MLLT2/AF4; insertion ins(5;11)(q31;q13q23) with AFF4/AF5Q31; translocation t(5;11)(q12;q23) with AF5-alpha/CENPK; translocation t(6;11)(q27;q23) with MLLT4/AF6; translocation t(9;11)(p22;q23) with MLLT3/AF9; translocation t(10;11)(p11.2;q23) with ABI1; translocation t(10;11)(p12;q23) with MLLT10/AF10; t(11;15)(q23;q14) with CASC5 and ZFYVE19; translocation t(11;17)(q23;q21) with MLLT6/AF17; translocation t(11;19)(q23;p13.3) with ELL; translocation t(11;19)(q23;p13.3) with MLLT1/ENL; translocation t(11;19)(q23;p23) with GAS7; translocation t(X;11)(q13;q23) with FOXO4/AFX1. Translocation t(3;11)(q28;q23) with LPP. Translocation t(10;11)(q22;q23) with TET1. Translocation t(9;11)(q34;q23) with DAB2IP. Translocation t(4;11)(p12;q23) with FRYL. Fusion proteins MLL-MLLT1, MLL-MLLT3 and MLL-ELL interact with PPP1R15A and, on the contrary to unfused MLL, inhibit PPP1R15A-induced apoptosis. A chromosomal aberration involving MLL may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with SEPT11. Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: cytoplasm; histone methyltransferase complex; nucleoplasm; nucleus

Molecular Function: histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; identical protein binding; protein binding; protein homodimerization activity; unmethylated CpG binding; zinc ion binding

Biological Process: circadian regulation of gene expression; embryonic hemopoiesis; histone H3-K4 methylation; positive regulation of histone H3-K4 methylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transporter activity; protein complex assembly; transcription from RNA polymerase II promoter

Disease: Hairy Elbows, Short Stature, Facial Dysmorphism, And Developmental Delay
 KMT2A ELISA Kit
 KMT2A Recombinant
 KMT2A Antibody
 ALL1 ELISA Kit
 ALL1 Recombinant
 ALL1 Antibody
 CXXC7 ELISA Kit
 CXXC7 Recombinant
 CXXC7 Antibody
 HRX ELISA Kit
 HRX Recombinant
 HRX Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase 2B

 Histone-lysine N-methyltransferase 2B ELISA Kit
 Histone-lysine N-methyltransferase 2B Recombinant
 Histone-lysine N-methyltransferase 2B Antibody
Also known as Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (Myeloid/lymphoid or mixed-lineage leukemia protein 4 homolog) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7).
MLL2: may be a transcriptional regulator. Contains 3 A.T hook DNA-binding domains. Two alternatively spliced isoforms have been described.

Protein type: DNA-binding; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine; Transcription factor

Cellular Component: histone methyltransferase complex; nucleus

Molecular Function: histone lysine N-methyltransfer
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ase activity (H3-K4 specific)

Biological Process: gene silencing; histone H3-K4 methylation; memory; oocyte differentiation; ovarian follicle development; ovulation; regulation of histone H3-K4 methylation
 Kmt2b ELISA Kit
 Kmt2b Recombinant
 Kmt2b Antibody
 Mll2 ELISA Kit
 Mll2 Recombinant
 Mll2 Antibody
 Trx2 ELISA Kit
 Trx2 Recombinant
 Trx2 Antibody
 Wbp7 ELISA Kit
 Wbp7 Recombinant
 Wbp7 Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase 2C

 Histone-lysine N-methyltransferase 2C ELISA Kit
 Histone-lysine N-methyltransferase 2C Recombinant
 Histone-lysine N-methyltransferase 2C Antibody
Also known as Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3).
MLL3: a protein methyltransferase that methylates K4 of histone H3. H3K4 methylation represents a specific tag for epigenetic transcriptional activation. Found in a critical region of chromosome 7, which is commonly deleted in malignant myeloid disorders. Partial duplication of the MLL3 gene are found in the juxtacentromeric region of chromosomes 1, 2, 13 and 21. Central component of the MLL2/3 complex, a coactivator complex
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of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex. Contributes to genome-scale circadian transcription. May be involved in leukemogenesis and developmental disorder. Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver. Belongs to the protein lysine methyltransferase family. TRX/MLL subfamily. Three isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: histone methyltransferase complex; nucleoplasm; nucleus

Molecular Function: histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; protein binding
 KMT2C ELISA Kit
 KMT2C Recombinant
 KMT2C Antibody
 HALR ELISA Kit
 HALR Recombinant
 HALR Antibody
 KIAA1506 ELISA Kit
 KIAA1506 Recombinant
 KIAA1506 Antibody
 MLL3 ELISA Kit
 MLL3 Recombinant
 MLL3 Antibody
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Histone-lysine N-methyltransferase 2D

 Histone-lysine N-methyltransferase 2D ELISA Kit
 Histone-lysine N-methyltransferase 2D Recombinant
 Histone-lysine N-methyltransferase 2D Antibody
Also known as Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2).
MLL4: Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. Defects in MLL2 are the cause of Kabuki syndrome type 1 (KABUK1). A congenital mental retardation syndrome with additional features, including postnatal dwarfism, a peculiar fa
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cies characterized by long palpebral fissures with eversion of the lateral third of the lower eyelids, a broad and depressed nasal tip, large prominent earlobes, a cleft or high-arched palate, scoliosis, short fifth finger, persistence of fingerpads, radiographic abnormalities of the vertebrae, hands, and hip joints, and recurrent otitis media in infancy. Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine; Nuclear receptor co-regulator; Transcription regulation

Cellular Component: histone methyltransferase complex

Molecular Function: protein binding

Biological Process: chromatin silencing; histone H3-K4 methylation; in utero embryonic development; oocyte growth; oogenesis; positive regulation of cell proliferation; positive regulation of estrogen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression; response to estrogen stimulus
 Kmt2d ELISA Kit
 Kmt2d Recombinant
 Kmt2d Antibody
 Mll2 ELISA Kit
 Mll2 Recombinant
 Mll2 Antibody
 Mll4 ELISA Kit
 Mll4 Recombinant
 Mll4 Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase 2E

 Histone-lysine N-methyltransferase 2E ELISA Kit
 Histone-lysine N-methyltransferase 2E Recombinant
 Histone-lysine N-methyltransferase 2E Antibody
Also known as Histone-lysine N-methyltransferase 2E (Lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5 homolog).
MLL5: Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involve
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d in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic- acid-induced granulopoiesis by acting as a coactivator of RAR- alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases. Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine; Transcription, coactivator/corepressor

Cellular Component: intercellular bridge; intracellular membrane-bound organelle; nucleoplasm

Molecular Function: enzyme binding; histone lysine N-methyltransferase activity (H3-K4 specific); transcription coactivator activity

Biological Process: DNA methylation; erythrocyte differentiation; histone H3-K4 methylation; neutrophil activation; neutrophil mediated immunity; positive regulation of granulocyte differentiation; positive regulation of transcription, DNA-dependent; retinoic acid receptor signaling pathway
 Kmt2e ELISA Kit
 Kmt2e Recombinant
 Kmt2e Antibody
 Mll5 ELISA Kit
 Mll5 Recombinant
 Mll5 Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase ash1

 Histone-lysine N-methyltransferase ash1 ELISA Kit
 Histone-lysine N-methyltransferase ash1 Recombinant
 Histone-lysine N-methyltransferase ash1 Antibody
Also known as Histone-lysine N-methyltransferase ash1 (Absent small and homeotic disks protein 1) (Lysine N-methyltransferase 2H).
Trithorax group (TrxG) protein that has histone methyltransferase activity (PubMed:13679578, PubMed:16882982). Specifically trimethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation (PubMed:13679578, PubMed:16882982). TrxG proteins are generally required to maintain the transcriptionally active state of homeotic genes throughout development. Does not act as a coactivator required for transcriptional activation, but specificall
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y prevents inappropriate Polycomb Group (PcG) silencing of homeotic genes in cells in which they must stay transcriptionally active (PubMed:15031712).
 ash1 ELISA Kit
 ash1 Recombinant
 ash1 Antibody
 KMT2H ELISA Kit
 KMT2H Recombinant
 KMT2H Antibody
 CG8887 ELISA Kit
 CG8887 Recombinant
 CG8887 Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase ASH1L

 Histone-lysine N-methyltransferase ASH1L ELISA Kit
 Histone-lysine N-methyltransferase ASH1L Recombinant
 Histone-lysine N-methyltransferase ASH1L Antibody
Also known as Histone-lysine N-methyltransferase ASH1L (ASH1-like protein) (Absent small and homeotic disks protein 1 homolog).
ASH1L: a protein methyltransferase that specifically methylates K36 of histone H3 (H3K36me). A member of the trithorax group (trxG) of transcriptional activators that is required for proper expression of Hox genes and is preferentially expressed in haematopoietic stem
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cells. Widely expressed, with high levels in brain, heart and kidney. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions.

Protein type: Amino Acid Metabolism - lysine degradation; Cell adhesion; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Cellular Component: cytoplasm; Golgi apparatus; nucleoplasm

Molecular Function: histone lysine N-methyltransferase activity (H3-K36 specific); histone lysine N-methyltransferase activity (H3-K4 specific)

Biological Process: decidualization; histone H3-K4 methylation; interleukin-6 production; negative regulation of acute inflammatory response; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of inflammatory response; negative regulation of MAPKKK cascade; positive regulation of transcription from RNA polymerase II promoter; post-embryonic development; regulation of gene expression; sebaceous gland development; single fertilization; skeletal development
 Ash1l ELISA Kit
 Ash1l Recombinant
 Ash1l Antibody
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Histone-lysine N-methyltransferase ASHH1

 Histone-lysine N-methyltransferase ASHH1 ELISA Kit
 Histone-lysine N-methyltransferase ASHH1 Recombinant
 Histone-lysine N-methyltransferase ASHH1 Antibody
Also known as Histone-lysine N-methyltransferase ASHH1 (ASH1 homolog 1) (Protein SET DOMAIN GROUP 26).
Histone methyltransferase involved in regulation of flowering time. Required for the expression of the SOC1/AGL20 gene. Required for histone H3 trimethylation on 'Lys-4' (H3K4me3) at the SOC1 locus. Prevents trimethylation on 'Lys-27' (H3K27me3) at the same locus.
 ASHH1 ELISA Kit
 ASHH1 Recombinant
 ASHH1 Antibody
 SDG26 ELISA Kit
 SDG26 Recombinant
 SDG26 Antibody
 SET26 ELISA Kit
 SET26 Recombinant
 SET26 Antibody
 At1g76710 ELISA Kit
 At1g76710 Recombinant
 At1g76710 Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase ASHH2

 Histone-lysine N-methyltransferase ASHH2 ELISA Kit
 Histone-lysine N-methyltransferase ASHH2 Recombinant
 Histone-lysine N-methyltransferase ASHH2 Antibody
Also known as Histone-lysine N-methyltransferase ASHH2 (ASH1 homolog 2) (H3-K4-HMTase) (Histone H3-K36 methyltransferase 8) (H3-K36-HMTase 8) (Protein EARLY FLOWERING IN SHORT DAYS) (Protein LAZARUS 2) (Protein SET DOMAIN GROUP 8).
Encodes a protein with histone lysine N-methyltransferase activity required specifically for the trimethylation of H3-K4 in FLC chromatin (and not in H3-K36 dimethylation). Acts as an inhibitor of flowering specifically involved in the autonomous promotion pathway. EFS also regulates the expression of genes involved in carotenoid biosynthesis.Modification of hist
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one methylation at the CRTISO locus reduces transcript levels 90%. The increased shoot branching seen in some EFS mutants is likely due to the carotenoid biosynthesis defect having an effect on stringolactones.Required for ovule, embryo sac, anther and pollen development.
 ASHH2 ELISA Kit
 ASHH2 Recombinant
 ASHH2 Antibody
 EFS ELISA Kit
 EFS Recombinant
 EFS Antibody
 LAZ2 ELISA Kit
 LAZ2 Recombinant
 LAZ2 Antibody
 SDG8 ELISA Kit
 SDG8 Recombinant
 SDG8 Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase ASHH3

 Histone-lysine N-methyltransferase ASHH3 ELISA Kit
 Histone-lysine N-methyltransferase ASHH3 Recombinant
 Histone-lysine N-methyltransferase ASHH3 Antibody
Also known as Histone-lysine N-methyltransferase ASHH3 (ASH1 homolog 3) (Protein SET DOMAIN GROUP 7).
Encodes a protein-lysine N-methyltransferase. Located in ER.
 ASHH3 ELISA Kit
 ASHH3 Recombinant
 ASHH3 Antibody
 SDG7 ELISA Kit
 SDG7 Recombinant
 SDG7 Antibody
 SET7 ELISA Kit
 SET7 Recombinant
 SET7 Antibody
 At2g44150 ELISA Kit
 At2g44150 Recombinant
 At2g44150 Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase ASHR1

 Histone-lysine N-methyltransferase ASHR1 ELISA Kit
 Histone-lysine N-methyltransferase ASHR1 Recombinant
 Histone-lysine N-methyltransferase ASHR1 Antibody
Also known as Histone-lysine N-methyltransferase ASHR1 (ASH1-related protein 1) (Protein SET DOMAIN GROUP 37).
Homology Subgroup S-ET - Protein containing an interrupted SET domain.
 ASHR1 ELISA Kit
 ASHR1 Recombinant
 ASHR1 Antibody
 SDG37 ELISA Kit
 SDG37 Recombinant
 SDG37 Antibody
 SET37 ELISA Kit
 SET37 Recombinant
 SET37 Antibody
 At2g17900 ELISA Kit
 At2g17900 Recombinant
 At2g17900 Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase ASHR2

 Histone-lysine N-methyltransferase ASHR2 ELISA Kit
 Histone-lysine N-methyltransferase ASHR2 Recombinant
 Histone-lysine N-methyltransferase ASHR2 Antibody
Also known as Histone-lysine N-methyltransferase ASHR2 (ASH1-related protein 2) (Protein SET DOMAIN GROUP 39).
Histone methyltransferase.
 ASHR2 ELISA Kit
 ASHR2 Recombinant
 ASHR2 Antibody
 SDG39 ELISA Kit
 SDG39 Recombinant
 SDG39 Antibody
 SET39 ELISA Kit
 SET39 Recombinant
 SET39 Antibody
 At2g19640 ELISA Kit
 At2g19640 Recombinant
 At2g19640 Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase ASHR3

 Histone-lysine N-methyltransferase ASHR3 ELISA Kit
 Histone-lysine N-methyltransferase ASHR3 Recombinant
 Histone-lysine N-methyltransferase ASHR3 Antibody
Also known as Histone-lysine N-methyltransferase ASHR3 (ASH1-related protein 3) (Protein SET DOMAIN GROUP 4) (Protein stamen loss).
Histone methyltransferase (). Involved in stamen development.
 ASHR3 ELISA Kit
 ASHR3 Recombinant
 ASHR3 Antibody
 SDG4 ELISA Kit
 SDG4 Recombinant
 SDG4 Antibody
 SET4 ELISA Kit
 SET4 Recombinant
 SET4 Antibody
 SML ELISA Kit
 SML Recombinant
 SML Antibody
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Histone-lysine N-methyltransferase ATX1

 Histone-lysine N-methyltransferase ATX1 ELISA Kit
 Histone-lysine N-methyltransferase ATX1 Recombinant
 Histone-lysine N-methyltransferase ATX1 Antibody
Also known as Histone-lysine N-methyltransferase ATX1 (Protein SET DOMAIN GROUP 27) (Trithorax-homolog protein 1) (TRX-homolog protein 1).
Encodes a homolog of trithorax, a histone-lysine N-methyltransferase. Involved in trimethylating histone H3-lysine 4. Involved in the formation, placement, and identity of flower organs. Role in regulation of homeotic genes. Functions as a receptor of phosphatidylinositol 5-phosphate. Localizes to cytoplasm, plasma membrane and nuclei, shifting to nuclei in the presence of PI5P.
 ATX1 ELISA Kit
 ATX1 Recombinant
 ATX1 Antibody
 SDG27 ELISA Kit
 SDG27 Recombinant
 SDG27 Antibody
 SET27 ELISA Kit
 SET27 Recombinant
 SET27 Antibody
 TRX1 ELISA Kit
 TRX1 Recombinant
 TRX1 Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase ATX2

 Histone-lysine N-methyltransferase ATX2 ELISA Kit
 Histone-lysine N-methyltransferase ATX2 Recombinant
 Histone-lysine N-methyltransferase ATX2 Antibody
Also known as Histone-lysine N-methyltransferase ATX2 (Protein SET DOMAIN GROUP 30) (Trithorax-homolog protein 2) (TRX-homolog protein 2).
Encodes a homolog of trithorax, a histone-lysine N-methyltransferase. Paralog of ATX1. Unlike ATX1 which is involved in trimethylating of histone H3-mysine 4, ATX2 is involved in dimethylating of histone H3-lysine 4. ATX1 and ATX2 influence the expression of largely nonoverlapping gene sets. The expression pattern of ATX2 is also different from that of ATX1.
 ATX2 ELISA Kit
 ATX2 Recombinant
 ATX2 Antibody
 SDG30 ELISA Kit
 SDG30 Recombinant
 SDG30 Antibody
 SET30 ELISA Kit
 SET30 Recombinant
 SET30 Antibody
 At1g05830 ELISA Kit
 At1g05830 Recombinant
 At1g05830 Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase ATX3

 Histone-lysine N-methyltransferase ATX3 ELISA Kit
 Histone-lysine N-methyltransferase ATX3 Recombinant
 Histone-lysine N-methyltransferase ATX3 Antibody
Also known as Histone-lysine N-methyltransferase ATX3 (Protein SET DOMAIN GROUP 14) (Trithorax-homolog protein 3) (TRX-homolog protein 3).
Histone methyltransferase.
 ATX3 ELISA Kit
 ATX3 Recombinant
 ATX3 Antibody
 SDG14 ELISA Kit
 SDG14 Recombinant
 SDG14 Antibody
 SET14 ELISA Kit
 SET14 Recombinant
 SET14 Antibody
 At3g61740 ELISA Kit
 At3g61740 Recombinant
 At3g61740 Antibody
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Histone-lysine N-methyltransferase ATX4

 Histone-lysine N-methyltransferase ATX4 ELISA Kit
 Histone-lysine N-methyltransferase ATX4 Recombinant
 Histone-lysine N-methyltransferase ATX4 Antibody
Also known as Histone-lysine N-methyltransferase ATX4 (Protein SET DOMAIN GROUP 16) (Trithorax-homolog protein 4) (TRX-homolog protein 4) (Trithorax 4).
Histone methyltransferase.
 ATX4 ELISA Kit
 ATX4 Recombinant
 ATX4 Antibody
 SDG16 ELISA Kit
 SDG16 Recombinant
 SDG16 Antibody
 SET16 ELISA Kit
 SET16 Recombinant
 SET16 Antibody
 TX4 ELISA Kit
 TX4 Recombinant
 TX4 Antibody
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Histone-lysine N-methyltransferase ATX5

 Histone-lysine N-methyltransferase ATX5 ELISA Kit
 Histone-lysine N-methyltransferase ATX5 Recombinant
 Histone-lysine N-methyltransferase ATX5 Antibody
Also known as Histone-lysine N-methyltransferase ATX5 (Protein SET DOMAIN GROUP 29) (Trithorax-homolog protein 5) (TRX-homolog protein 5).
Homology Subgroup III; Orthology Group 2 - A putative histone methyltransferase (predicted to methylate H3K4) related to the Drosophila trithorax group proteins TRX and TRR and the yeast gene SET1. A plant line expressing an RNAi construct directed against this gene has reduced agrobacterium-mediated tumor formation.
 ATX5 ELISA Kit
 ATX5 Recombinant
 ATX5 Antibody
 SDG29 ELISA Kit
 SDG29 Recombinant
 SDG29 Antibody
 SET29 ELISA Kit
 SET29 Recombinant
 SET29 Antibody
 At5g53430 ELISA Kit
 At5g53430 Recombinant
 At5g53430 Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase ATXR2

 Histone-lysine N-methyltransferase ATXR2 ELISA Kit
 Histone-lysine N-methyltransferase ATXR2 Recombinant
 Histone-lysine N-methyltransferase ATXR2 Antibody
Also known as Histone-lysine N-methyltransferase ATXR2 (Protein SET DOMAIN GROUP 36) (Trithorax-related protein 2) (TRX-related protein 2).
Histone methyltransferase.
 ATXR2 ELISA Kit
 ATXR2 Recombinant
 ATXR2 Antibody
 SDG36 ELISA Kit
 SDG36 Recombinant
 SDG36 Antibody
 SET36 ELISA Kit
 SET36 Recombinant
 SET36 Antibody
 At3g21820 ELISA Kit
 At3g21820 Recombinant
 At3g21820 Antibody
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Histone-lysine N-methyltransferase ATXR3

 Histone-lysine N-methyltransferase ATXR3 ELISA Kit
 Histone-lysine N-methyltransferase ATXR3 Recombinant
 Histone-lysine N-methyltransferase ATXR3 Antibody
Also known as Histone-lysine N-methyltransferase ATXR3 (Protein SET DOMAIN GROUP 2) (Trithorax-related protein 3) (TRX-related protein 3).
Histone methyltransferase specifically required for trimethylation of 'Lys-4' of histone H3 (H3K4me3) and is crucial for both sporophyte and gametophyte development (PubMed:21037105, PubMed:20937886).
 ATXR3 ELISA Kit
 ATXR3 Recombinant
 ATXR3 Antibody
 SDG2 ELISA Kit
 SDG2 Recombinant
 SDG2 Antibody
 SET2 ELISA Kit
 SET2 Recombinant
 SET2 Antibody
 At4g15180 ELISA Kit
 At4g15180 Recombinant
 At4g15180 Antibody
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Histone-lysine N-methyltransferase ATXR4

 Histone-lysine N-methyltransferase ATXR4 ELISA Kit
 Histone-lysine N-methyltransferase ATXR4 Recombinant
 Histone-lysine N-methyltransferase ATXR4 Antibody
Also known as Histone-lysine N-methyltransferase ATXR4 (Protein SET DOMAIN GROUP 38) (Trithorax-related protein 4) (TRX-related protein 4).
Histone methyltransferase.
 ATXR4 ELISA Kit
 ATXR4 Recombinant
 ATXR4 Antibody
 SDG38 ELISA Kit
 SDG38 Recombinant
 SDG38 Antibody
 SET38 ELISA Kit
 SET38 Recombinant
 SET38 Antibody
 At5g06620 ELISA Kit
 At5g06620 Recombinant
 At5g06620 Antibody
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Histone-lysine N-methyltransferase ATXR5

 Histone-lysine N-methyltransferase ATXR5 ELISA Kit
 Histone-lysine N-methyltransferase ATXR5 Recombinant
 Histone-lysine N-methyltransferase ATXR5 Antibody
Also known as Histone-lysine N-methyltransferase ATXR5 (Protein SET DOMAIN GROUP 15) (Trithorax-related protein 5) (TRX-related protein 5).
Encodes a SET-domain protein, a H3K27 monomethyltransferases required for chromatin structure and gene silencing. Regulates heterochromatic DNA replication. Contains a PCNA-binding domain. ATXR5 accumulates preferentially during the late G1 or S phase, suggesting that it plays a role in cell-cycle regulation or progression. A plant line expressing an RNAi construct directed against this gene has reduced agrobacterium-mediated tumor formation.
 ATXR5 ELISA Kit
 ATXR5 Recombinant
 ATXR5 Antibody
 SDG15 ELISA Kit
 SDG15 Recombinant
 SDG15 Antibody
 SET15 ELISA Kit
 SET15 Recombinant
 SET15 Antibody
 At5g09790 ELISA Kit
 At5g09790 Recombinant
 At5g09790 Antibody
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Histone-lysine N-methyltransferase ATXR6

 Histone-lysine N-methyltransferase ATXR6 ELISA Kit
 Histone-lysine N-methyltransferase ATXR6 Recombinant
 Histone-lysine N-methyltransferase ATXR6 Antibody
Also known as Histone-lysine N-methyltransferase ATXR6 (Protein SET DOMAIN GROUP 34) (Trithorax-related protein 6) (TRX-related protein 6).
Encodes a SET-domain protein, a H3K27 monomethyltransferases required for chromatin structure and gene silencing. Regulates heterochromatic DNA replication. Contains a PCNA-binding domain. ATXR6 accumulates preferentially during the late G1 or S phase, suggesting that it plays a role in cell-cycle regulation or progression.
 ATXR6 ELISA Kit
 ATXR6 Recombinant
 ATXR6 Antibody
 SDG34 ELISA Kit
 SDG34 Recombinant
 SDG34 Antibody
 SET34 ELISA Kit
 SET34 Recombinant
 SET34 Antibody
 At5g24330 ELISA Kit
 At5g24330 Recombinant
 At5g24330 Antibody
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Histone-lysine N-methyltransferase ATXR7

 Histone-lysine N-methyltransferase ATXR7 ELISA Kit
 Histone-lysine N-methyltransferase ATXR7 Recombinant
 Histone-lysine N-methyltransferase ATXR7 Antibody
Also known as Histone-lysine N-methyltransferase ATXR7 (Protein SET DOMAIN GROUP 25) (Trithorax-related protein 7).
Histone methyltransferase involved in regulation of flowering time. Required for the expression of the flowering repressors FLC and MADS-box genes of the MAF family (PubMed:19726574, PubMed:19855050). Required for histone H3 dimethylation on 'Lys-36' H3K36me2 at the FLC locus (PubMed:19726574). Required for histone H3 trimethylation on 'Lys-4' (H3K4me3) at the FLC locus. Prevents trimethylation on 'Lys-27' (H3K27me3) at the same locus (PubMed:19855050). Involved in the control
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of seed dormancy and germination (PubMed:21799800).
 ATXR7 ELISA Kit
 ATXR7 Recombinant
 ATXR7 Antibody
 SDG25 ELISA Kit
 SDG25 Recombinant
 SDG25 Antibody
 At5g42400 ELISA Kit
 At5g42400 Recombinant
 At5g42400 Antibody
 MDH9.9 ELISA Kit
 MDH9.9 Recombinant
 MDH9.9 Antibody
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Histone-lysine N-methyltransferase CLF

 Histone-lysine N-methyltransferase CLF ELISA Kit
 Histone-lysine N-methyltransferase CLF Recombinant
 Histone-lysine N-methyltransferase CLF Antibody
Also known as Histone-lysine N-methyltransferase CLF (Polycomb group protein CURLY LEAF) (Protein INCURVATA 1) (Protein SET DOMAIN GROUP 1) (Protein photoperiod insensitive flowering).
Similar to the product of the Polycomb-group gene Enhancer of zeste. Required for stable repression of AG and AP3. Putative role in cell fate determination. Involved in the control of leaf morphogenesis. mutants exhibit curled, involute leaves. AGAMOUS and APETALA3 are ectopically expressed in the mutant.
 CLF ELISA Kit
 CLF Recombinant
 CLF Antibody
 ICU1 ELISA Kit
 ICU1 Recombinant
 ICU1 Antibody
 PIF1 ELISA Kit
 PIF1 Recombinant
 PIF1 Antibody
 PIF2 ELISA Kit
 PIF2 Recombinant
 PIF2 Antibody
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Histone-lysine N-methyltransferase E

 Histone-lysine N-methyltransferase E ELISA Kit
 Histone-lysine N-methyltransferase E Recombinant
 Histone-lysine N-methyltransferase E Antibody
Also known as Histone-lysine N-methyltransferase E(z) (Lysine N-methyltransferase 6) (Protein enhancer of zeste).
Polycomb group (PcG) protein. Catalytic subunit of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. The Esc/E(z) complex is necessary but not
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sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required.
 E(z) ELISA Kit
 E(z) Recombinant
 E(z) Antibody
 KMT6 ELISA Kit
 KMT6 Recombinant
 KMT6 Antibody
 CG6502 ELISA Kit
 CG6502 Recombinant
 CG6502 Antibody
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Histone-lysine N-methyltransferase eggless

 Histone-lysine N-methyltransferase eggless ELISA Kit
 Histone-lysine N-methyltransferase eggless Recombinant
 Histone-lysine N-methyltransferase eggless Antibody
Also known as Histone-lysine N-methyltransferase eggless (SETDB1 homolog).
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 in ovary. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Plays a central role during oogenesis.
 egg ELISA Kit
 egg Recombinant
 egg Antibody
 CG12196 ELISA Kit
 CG12196 Recombinant
 CG12196 Antibody
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Histone-lysine N-methyltransferase EHMT1

 Histone-lysine N-methyltransferase EHMT1 ELISA Kit
 Histone-lysine N-methyltransferase EHMT1 Recombinant
 Histone-lysine N-methyltransferase EHMT1 Antibody
Also known as Histone-lysine N-methyltransferase EHMT1 (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D).
EHMT1: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methy
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lation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non- histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Defects in EHMT1 are the cause of chromosome 9q subtelomeric deletion syndrome (9q- syndrome). Common features seen in these patients are severe mental retardation, hypotonia, brachy(micro)cephaly, epileptic seizures, flat face with hypertelorism, synophrys, anteverted nares, cupid bow or tented upper lip, everted lower lip, prognathism, macroglossia, conotruncal heart defects, and behavioral problems. Belongs to the histone-lysine methyltransferase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: nucleoplasm; nucleus

Molecular Function: histone lysine N-methyltransferase activity (H3-K27 specific); histone lysine N-methyltransferase activity (H3-K9 specific); histone-lysine N-methyltransferase activity; methyltransferase activity; p53 binding; protein binding; protein-lysine N-methyltransferase activity

Biological Process: DNA methylation; embryonic development; establishment and/or maintenance of chromatin architecture; histone methylation; negative regulation of transcription, DNA-dependent; peptidyl-lysine di-methylation; peptidyl-lysine mono-methylation

Disease: Kleefstra Syndrome
 EHMT1 ELISA Kit
 EHMT1 Recombinant
 EHMT1 Antibody
 EUHMTASE1 ELISA Kit
 EUHMTASE1 Recombinant
 EUHMTASE1 Antibody
 GLP ELISA Kit
 GLP Recombinant
 GLP Antibody
 KIAA1876 ELISA Kit
 KIAA1876 Recombinant
 KIAA1876 Antibody
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Histone-lysine N-methyltransferase EHMT2

 Histone-lysine N-methyltransferase EHMT2 ELISA Kit
 Histone-lysine N-methyltransferase EHMT2 Recombinant
 Histone-lysine N-methyltransferase EHMT2 Antibody
Also known as Histone-lysine N-methyltransferase EHMT2 (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a).
This gene encodes a methyltransferase that methylates lysine residues of histone H3. Methylation of H3 at lysine 9 by this protein results in recruitment of additional epigenetic regulators and repression of transcription. This gene was initially thought to be two different genes, NG36 and G9a, adjacent to each other in the HLA locus. Alternative splicing r
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esults in multiple transcript variants. [provided by RefSeq, Jan 2016]
 EHMT2 ELISA Kit
 EHMT2 Recombinant
 EHMT2 Antibody
 BAT8 ELISA Kit
 BAT8 Recombinant
 BAT8 Antibody
 C6orf30 ELISA Kit
 C6orf30 Recombinant
 C6orf30 Antibody
 G9A ELISA Kit
 G9A Recombinant
 G9A Antibody
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Histone-lysine N-methyltransferase EZ1

 Histone-lysine N-methyltransferase EZ1 ELISA Kit
 Histone-lysine N-methyltransferase EZ1 Recombinant
 Histone-lysine N-methyltransferase EZ1 Antibody
Also known as Histone-lysine N-methyltransferase EZ1 (Enhancer of zeste protein 1).
Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins are not required to initiate repression, but to maintain it during later stages of development ().
 EZ1 ELISA Kit
 EZ1 Recombinant
 EZ1 Antibody
 MEZ1 ELISA Kit
 MEZ1 Recombinant
 MEZ1 Antibody
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Histone-lysine N-methyltransferase EZ2

 Histone-lysine N-methyltransferase EZ2 ELISA Kit
 Histone-lysine N-methyltransferase EZ2 Recombinant
 Histone-lysine N-methyltransferase EZ2 Antibody
Also known as Histone-lysine N-methyltransferase EZ2 (Enhancer of zeste protein 2).
Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins are not required to initiate repression, but to maintain it during later stages of development ().
 EZ2 ELISA Kit
 EZ2 Recombinant
 EZ2 Antibody
 MEZ2 ELISA Kit
 MEZ2 Recombinant
 MEZ2 Antibody
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Histone-lysine N-methyltransferase EZ3

 Histone-lysine N-methyltransferase EZ3 ELISA Kit
 Histone-lysine N-methyltransferase EZ3 Recombinant
 Histone-lysine N-methyltransferase EZ3 Antibody
Also known as Histone-lysine N-methyltransferase EZ3 (Enhancer of zeste protein 3).
Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins are not required to initiate repression, but to maintain it during later stages of development ().
 EZ3 ELISA Kit
 EZ3 Recombinant
 EZ3 Antibody
 MEZ3 ELISA Kit
 MEZ3 Recombinant
 MEZ3 Antibody
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Histone-lysine N-methyltransferase EZA1

 Histone-lysine N-methyltransferase EZA1 ELISA Kit
 Histone-lysine N-methyltransferase EZA1 Recombinant
 Histone-lysine N-methyltransferase EZA1 Antibody
Also known as Histone-lysine N-methyltransferase EZA1 (CURLY LEAF-like 1) (Protein SET DOMAIN GROUP 10) (Protein SWINGER).
Encodes a polycomb group protein. Forms part of a large protein complex that can include VRN2 (VERNALIZATION 2), VIN3 (VERNALIZATION INSENSITIVE 3) and polycomb group proteins FERTILIZATION INDEPENDENT ENDOSPERM (FIE) and CURLY LEAF (CLF). The complex has a role in establishing FLC (FLOWERING LOCUS C) repression during vernalization. Performs a partially redundant role to MEA in controlling seed initiation by helping to suppress central cell nucleus#endosperm proliferat
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ion within the FG.
 EZA1 ELISA Kit
 EZA1 Recombinant
 EZA1 Antibody
 SDG10 ELISA Kit
 SDG10 Recombinant
 SDG10 Antibody
 SET10 ELISA Kit
 SET10 Recombinant
 SET10 Antibody
 SWN ELISA Kit
 SWN Recombinant
 SWN Antibody
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Histone-lysine N-methyltransferase EZH1

 Histone-lysine N-methyltransferase EZH1 ELISA Kit
 Histone-lysine N-methyltransferase EZH1 Recombinant
 Histone-lysine N-methyltransferase EZH1 Antibody
Also known as Histone-lysine N-methyltransferase EZH1 (Enhancer of zeste homolog 1).
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for
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embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation ().
 EZH1 ELISA Kit
 EZH1 Recombinant
 EZH1 Antibody
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Histone-lysine N-methyltransferase EZH2

 Histone-lysine N-methyltransferase EZH2 ELISA Kit
 Histone-lysine N-methyltransferase EZH2 Recombinant
 Histone-lysine N-methyltransferase EZH2 Antibody
Also known as Histone-lysine N-methyltransferase EZH2 (Enhancer of zeste homolog 2).
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and
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proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the CLOCK-ARNTL/BMAL1 transcriptional activation of PER1/2. Involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription.
 EZH2 ELISA Kit
 EZH2 Recombinant
 EZH2 Antibody
 QtsA-15957 ELISA Kit
 QtsA-15957 Recombinant
 QtsA-15957 Antibody
 QtsA-18821 ELISA Kit
 QtsA-18821 Recombinant
 QtsA-18821 Antibody
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Histone-lysine N-methyltransferase KMT5B

 Histone-lysine N-methyltransferase KMT5B ELISA Kit
 Histone-lysine N-methyltransferase KMT5B Recombinant
 Histone-lysine N-methyltransferase KMT5B Antibody
Also known as Histone-lysine N-methyltransferase KMT5B (Lysine N-methyltransferase 5B) (Lysine-specific methyltransferase 5B) (Suppressor of variegation 4-20 homolog 1) (Su(var)4-20 homolog 1) (Suv4-20h1).
SUV420H1: a protein methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its
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interaction with RB1 family proteins (RB1, RBL1 and RBL2). Strongly down-regulated in breast cancer cells. Belongs to the histone-lysine methyltransferase family. Suvar4-20 subfamily. Three alternatively-spliced isoforms have been described.

Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 11q13.2

Molecular Function: histone-lysine N-methyltransferase activity
 KMT5B ELISA Kit
 KMT5B Recombinant
 KMT5B Antibody
 SUV420H1 ELISA Kit
 SUV420H1 Recombinant
 SUV420H1 Antibody
 CGI-85 ELISA Kit
 CGI-85 Recombinant
 CGI-85 Antibody
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Histone-lysine N-methyltransferase KMT5B-A

 Histone-lysine N-methyltransferase KMT5B-A ELISA Kit
 Histone-lysine N-methyltransferase KMT5B-A Recombinant
 Histone-lysine N-methyltransferase KMT5B-A Antibody
Also known as Histone-lysine N-methyltransferase KMT5B-A (Lysine-specific methyltransferase 5B-A) (Suppressor of variegation 4-20 homolog 1-A) (Su(var)4-20 homolog 1-A) (Suv4-20h1-A).
Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric het
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erochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. Plays a role in myogenesis by regulating the expression of target genes ().
 kmt5b-a ELISA Kit
 kmt5b-a Recombinant
 kmt5b-a Antibody
 suv420h1-a ELISA Kit
 suv420h1-a Recombinant
 suv420h1-a Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase KMT5B-B

 Histone-lysine N-methyltransferase KMT5B-B ELISA Kit
 Histone-lysine N-methyltransferase KMT5B-B Recombinant
 Histone-lysine N-methyltransferase KMT5B-B Antibody
Also known as Histone-lysine N-methyltransferase KMT5B-B (Lysine-specific methyltransferase 5B-B) (Suppressor of variegation 4-20 homolog 1-B) (Su(var)4-20 homolog 1-B) (Suv4-20h1-B).
Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric het
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erochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. Plays a role in myogenesis by regulating the expression of target genes ().
 kmt5b-b ELISA Kit
 kmt5b-b Recombinant
 kmt5b-b Antibody
 suv420h1-b ELISA Kit
 suv420h1-b Recombinant
 suv420h1-b Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase KMT5C

 Histone-lysine N-methyltransferase KMT5C ELISA Kit
 Histone-lysine N-methyltransferase KMT5C Recombinant
 Histone-lysine N-methyltransferase KMT5C Antibody
Also known as Histone-lysine N-methyltransferase KMT5C (Lysine N-methyltransferase 5C) (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2).
SUV420H2: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its i
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nteraction with RB1 family proteins (RB1, RBL1 and RBL2). Belongs to the histone-lysine methyltransferase family. Suvar4-20 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: centric heterochromatin; nuclear heterochromatin; nucleoplasm

Molecular Function: protein binding
 KMT5C ELISA Kit
 KMT5C Recombinant
 KMT5C Antibody
 SUV420H2 ELISA Kit
 SUV420H2 Recombinant
 SUV420H2 Antibody
 PP7130 ELISA Kit
 PP7130 Recombinant
 PP7130 Antibody
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Histone-lysine N-methyltransferase MEDEA

 Histone-lysine N-methyltransferase MEDEA ELISA Kit
 Histone-lysine N-methyltransferase MEDEA Recombinant
 Histone-lysine N-methyltransferase MEDEA Antibody
Also known as Histone-lysine N-methyltransferase MEDEA (Maternal embryogenesis control protein) (Protein EMBRYO DEFECTIVE 173) (Protein FERTILIZATION-INDEPENDENT SEED 1) (Protein SET DOMAIN GROUP 5).
Encodes a putative transcription factor MEDEA (MEA) that negatively regulates seed development in the absence of fertilization. Mutations in this locus result in embryo lethality. MEA is a Polycomb group gene that is imprinted in the endosperm. The maternal allele is expressed and the paternal allele is silent. MEA is controlled by DEMETER (DME), a DNA glycosylase required to activate MEA expre
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ssion, and METHYLTRANSFERASE I (MET1), which maintains CG methylation at the MEA locus. MEA is involved in the negative regulation of its own imprinted gene expression; the effect is not only allele-specific but also dynamically regulated during seed development. In the ovule, the MEA transcripts are accumulated at their highest level before fertilization and gradually decrease after fertilization
 MEA ELISA Kit
 MEA Recombinant
 MEA Antibody
 EMB173 ELISA Kit
 EMB173 Recombinant
 EMB173 Antibody
 FIS1 ELISA Kit
 FIS1 Recombinant
 FIS1 Antibody
 MEDEA ELISA Kit
 MEDEA Recombinant
 MEDEA Antibody
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Histone-lysine N-methyltransferase mes-2

 Histone-lysine N-methyltransferase mes-2 ELISA Kit
 Histone-lysine N-methyltransferase mes-2 Recombinant
 Histone-lysine N-methyltransferase mes-2 Antibody
Also known as Histone-lysine N-methyltransferase mes-2 (E(z) homolog) (Maternal-effect sterile protein 2).
Polycomb group (PcG) protein. Catalytic subunit of a the mes-2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcript
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ionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X chromosomes in germline cells. This complex is required to exclude mes-4 from the inactivated X-chromosomes in germline cells (PubMed:12077420,PubMed:15380065). Required for small-RNA-induced H3K27 trimethylation (PubMed:26365259).
 mes-2 ELISA Kit
 mes-2 Recombinant
 mes-2 Antibody
 R06A4.7 ELISA Kit
 R06A4.7 Recombinant
 R06A4.7 Antibody
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Histone-lysine N-methyltransferase mes-4

 Histone-lysine N-methyltransferase mes-4 ELISA Kit
 Histone-lysine N-methyltransferase mes-4 Recombinant
 Histone-lysine N-methyltransferase mes-4 Antibody
Also known as Histone-lysine N-methyltransferase mes-4 (Maternal-effect sterile protein 4).
Histone methyltransferase. Dimethylates 'Lys-36' of histone H3, a specific tag for epigenetic transcriptional activation. Plays a central role in early development and is responsible for all H3 'Lys-36' dimethylation until about the 40-cell stage. Indirectly involved in the global inactivation of the X c
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hromosomes in germline cells, possibly by excluding the mes-2-mes-3-mes-6 repressive Polycomb complex from the autosomes (PubMed:12077420, PubMed:16968818). Not related to transcription elongation (PubMed:12077420, PubMed:16968818). Required for small-RNA-induced H3K27 trimethylation (PubMed:26365259).
 mes-4 ELISA Kit
 mes-4 Recombinant
 mes-4 Antibody
 Y2H9A.1 ELISA Kit
 Y2H9A.1 Recombinant
 Y2H9A.1 Antibody
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Histone-lysine N-methyltransferase met-2

 Histone-lysine N-methyltransferase met-2 ELISA Kit
 Histone-lysine N-methyltransferase met-2 Recombinant
 Histone-lysine N-methyltransferase met-2 Antibody
Histone methyltransferase which is required for the mono- and dimethylation of 'Lys-9' of histone H3. This increases the efficiency of set-25-mediated trimethylation of histone H3 'Lys-9'. Involved in the transcriptional repression of lin-3 which is required for the negative regulation of vulval cell fate specification during postembryonic development. Has a role in blocking checkpoint signaling a
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nd mediating the transcriptional silencing of meiotic sex chromosome inactivation; a mechanism which enables checkpoint proteins to distinguish between the partnerless male X chromosome and asynapsed chromosomes thereby shielding the lone X from inappropriate activation of an apoptotic program. Operates redundantly with set-25 to position chromatin at the nuclear periphery. Required for small-RNA-induced H3K9 methylation (PubMed:26365259). Together with set-25, protects and stabilizes repeat-rich genomic regions by suppressing transcription-induced replication stress through methylation of H3K9 (PubMed:27668659).
 met-2 ELISA Kit
 met-2 Recombinant
 met-2 Antibody
 R05D3.11 ELISA Kit
 R05D3.11 Recombinant
 R05D3.11 Antibody
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Histone-lysine N-methyltransferase NSD2

 Histone-lysine N-methyltransferase NSD2 ELISA Kit
 Histone-lysine N-methyltransferase NSD2 Recombinant
 Histone-lysine N-methyltransferase NSD2 Antibody
Also known as Histone-lysine N-methyltransferase NSD2 (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (NSD2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) (WHSC1).
WHSC1: a SET domain-containing protein lysine methyltransferase that is expressed normally in early development. Catalyzes the dimethylation of H3K36; H3K36me2 is associated with regions that are transcriptionally active. Maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in about 15% of t(4;14) multiple myeloma cases. Patients with th
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e t(4;14) chromosomal translocation comprise one of the worst prognostic subgroups of multiple myeloma. The t(4;14) translocation results in overexpression of WHSC1 and of FGFR3 due to the placement of the strong immunoglobulin H intronic Emu enhancer and 3-prime enhancer in the promoter regions of WHSC1 and FGFR3 genes, respectively. 100% of t(4;14) patients retain overexpression of WHSC1, while 30% have lost expression of FGFR3, suggesting that WHSC1 and not FGFR3 may the primary driver of the disease. Seven alternatively spliced isoforms of the human protein have been reported.

Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: nucleoplasm; nucleus

Molecular Function: histone lysine N-methyltransferase activity (H4-K20 specific); histone-lysine N-methyltransferase activity; protein binding

Biological Process: anatomical structure morphogenesis; double-strand break repair via nonhomologous end joining

Disease: Wolf-hirschhorn Syndrome
 WHSC1 ELISA Kit
 WHSC1 Recombinant
 WHSC1 Antibody
 KIAA1090 ELISA Kit
 KIAA1090 Recombinant
 KIAA1090 Antibody
 MMSET ELISA Kit
 MMSET Recombinant
 MMSET Antibody
 NSD2 ELISA Kit
 NSD2 Recombinant
 NSD2 Antibody
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Histone-lysine N-methyltransferase NSD3

 Histone-lysine N-methyltransferase NSD3 ELISA Kit
 Histone-lysine N-methyltransferase NSD3 Recombinant
 Histone-lysine N-methyltransferase NSD3 Antibody
Also known as Histone-lysine N-methyltransferase NSD3 (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein.
WHSC1L1: is related to the Wolf-Hirschhorn syndrome candidate-1 protein containing PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced isoforms have been described.

Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Histone-binding;
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Methyltransferase; Methyltransferase, protein lysine; Oncoprotein

Chromosomal Location of Human Ortholog: 8p11.2

Cellular Component: nucleoplasm; nucleus

Molecular Function: histone-lysine N-methyltransferase activity; protein binding

Biological Process: histone methylation

Disease: Leukemia, Acute Myeloid
 WHSC1L1 ELISA Kit
 WHSC1L1 Recombinant
 WHSC1L1 Antibody
 NSD3 ELISA Kit
 NSD3 Recombinant
 NSD3 Antibody
 DC28 ELISA Kit
 DC28 Recombinant
 DC28 Antibody
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Histone-lysine N-methyltransferase PRDM9

 Histone-lysine N-methyltransferase PRDM9 ELISA Kit
 Histone-lysine N-methyltransferase PRDM9 Recombinant
 Histone-lysine N-methyltransferase PRDM9 Antibody
Also known as Histone-lysine N-methyltransferase PRDM9 (Hybrid sterility protein 1) (Meiosis-induced factor containing a PR/SET domain and zinc-finger motif) (PR domain zinc finger protein 9) (PR domain-containing protein 9).
PRDM9: Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional a
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ctivation of genes during early meiotic prophase.

Protein type: C2H2-type zinc finger protein; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Cellular Component: nucleoplasm

Molecular Function: histone lysine N-methyltransferase activity (H3-K4 specific); sequence-specific DNA binding

Biological Process: histone methylation; meiotic gene conversion; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis
 Prdm9 ELISA Kit
 Prdm9 Recombinant
 Prdm9 Antibody
 Hst1 ELISA Kit
 Hst1 Recombinant
 Hst1 Antibody
 Meisetz ELISA Kit
 Meisetz Recombinant
 Meisetz Antibody
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Histone-lysine N-methyltransferase pr-set7

 Histone-lysine N-methyltransferase pr-set7 ELISA Kit
 Histone-lysine N-methyltransferase pr-set7 Recombinant
 Histone-lysine N-methyltransferase pr-set7 Antibody
Also known as Histone-lysine N-methyltransferase pr-set7 (Lysine N-methyltransferase 5A) (PR/SET domain-containing protein 07) (dSET8).
Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, possibly by contributing to the maintenance of proper higher-order structure of DNA and chromosome condens
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ation during mitosis.
 pr-set7 ELISA Kit
 pr-set7 Recombinant
 pr-set7 Antibody
 KMT5A ELISA Kit
 KMT5A Recombinant
 KMT5A Antibody
 CG3307 ELISA Kit
 CG3307 Recombinant
 CG3307 Antibody
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Histone-lysine N-methyltransferase set1

 Histone-lysine N-methyltransferase set1 ELISA Kit
 Histone-lysine N-methyltransferase set1 Recombinant
 Histone-lysine N-methyltransferase set1 Antibody
Also known as Histone-lysine N-methyltransferase set1 (Histone H3 lysine 4 methyltransferase) (SET domain-containing protein 1).
Histone methyltransferase that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. May act to regulate chromatin-mediated events.
 set1 ELISA Kit
 set1 Recombinant
 set1 Antibody
 H3K4 ELISA Kit
 H3K4 Recombinant
 H3K4 Antibody
 DDB_G0289257 ELISA Kit
 DDB_G0289257 Recombinant
 DDB_G0289257 Antibody
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Histone-lysine N-methyltransferase set9

 Histone-lysine N-methyltransferase set9 ELISA Kit
 Histone-lysine N-methyltransferase set9 Recombinant
 Histone-lysine N-methyltransferase set9 Antibody
Also known as Histone-lysine N-methyltransferase set9 (Histone-lysine methyltransferase 1) (SET domain protein 9).
Histone methyltransferase that specifically methylates 'Lys-20' of histone H4.
 hlm-1 ELISA Kit
 hlm-1 Recombinant
 hlm-1 Antibody
 set9 ELISA Kit
 set9 Recombinant
 set9 Antibody
 NCU08551 ELISA Kit
 NCU08551 Recombinant
 NCU08551 Antibody
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Histone-lysine N-methyltransferase SETD1

 Histone-lysine N-methyltransferase SETD1 ELISA Kit
 Histone-lysine N-methyltransferase SETD1 Recombinant
 Histone-lysine N-methyltransferase SETD1 Antibody
Catalytic component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and is the main di- and trimethyltransferase throughout development. Set1-dependent trimethylation regulates chromatin changes at active promoters that ensure optimal RNA polymerase II release into productive elongation, thereby contributing to optimal transcription.
 Set1 ELISA Kit
 Set1 Recombinant
 Set1 Antibody
 CG40351 ELISA Kit
 CG40351 Recombinant
 CG40351 Antibody
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Histone-lysine N-methyltransferase SETD1A

 Histone-lysine N-methyltransferase SETD1A ELISA Kit
 Histone-lysine N-methyltransferase SETD1A Recombinant
 Histone-lysine N-methyltransferase SETD1A Antibody
Also known as Histone-lysine N-methyltransferase SETD1A (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1).
SETD1A: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant c
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ontributions to the epigenetic control of chromatin structure and gene expression.

Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: histone methyltransferase complex; nuclear chromatin; nucleoplasm; nucleus

Molecular Function: beta-catenin binding; histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; protein binding; transcription factor binding
 SETD1A ELISA Kit
 SETD1A Recombinant
 SETD1A Antibody
 KIAA0339 ELISA Kit
 KIAA0339 Recombinant
 KIAA0339 Antibody
 KMT2F ELISA Kit
 KMT2F Recombinant
 KMT2F Antibody
 SET1 ELISA Kit
 SET1 Recombinant
 SET1 Antibody
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Histone-lysine N-methyltransferase SETD1B

 Histone-lysine N-methyltransferase SETD1B ELISA Kit
 Histone-lysine N-methyltransferase SETD1B Recombinant
 Histone-lysine N-methyltransferase SETD1B Antibody
Also known as Histone-lysine N-methyltransferase SETD1B (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B).
SETD1B: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structu
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re and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.

Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: cytoplasm; histone methyltransferase complex; nucleoplasm

Molecular Function: histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; protein binding

Biological Process: histone H3-K4 methylation
 SETD1B ELISA Kit
 SETD1B Recombinant
 SETD1B Antibody
 KIAA1076 ELISA Kit
 KIAA1076 Recombinant
 KIAA1076 Antibody
 KMT2G ELISA Kit
 KMT2G Recombinant
 KMT2G Antibody
 SET1B ELISA Kit
 SET1B Recombinant
 SET1B Antibody
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Histone-lysine N-methyltransferase SETD1B-A

 Histone-lysine N-methyltransferase SETD1B-A ELISA Kit
 Histone-lysine N-methyltransferase SETD1B-A Recombinant
 Histone-lysine N-methyltransferase SETD1B-A Antibody
Also known as Histone-lysine N-methyltransferase SETD1B-A (SET domain-containing protein 1B-A).
Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation ().
 setd1ba ELISA Kit
 setd1ba Recombinant
 setd1ba Antibody
 setd1b ELISA Kit
 setd1b Recombinant
 setd1b Antibody
 si:dkey-237o15.4 ELISA Kit
 si:dkey-237o15.4 Recombinant
 si:dkey-237o15.4 Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase SETD2

 Histone-lysine N-methyltransferase SETD2 ELISA Kit
 Histone-lysine N-methyltransferase SETD2 Recombinant
 Histone-lysine N-methyltransferase SETD2 Antibody
Also known as Histone-lysine N-methyltransferase SETD2 (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (SET domain-containing protein 2) (hSET2) (p231HBP).
SETD2: Histone methyltransferase that methylates 'Lys-36' of histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. Probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. Binds DNA at promoters. May also act as a transcr
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iption activator that binds to promoters. Binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. Belongs to the histone-lysine methyltransferase family. SET2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: nucleoplasm

Molecular Function: histone lysine N-methyltransferase activity (H3-K36 specific); histone-lysine N-methyltransferase activity; protein binding

Biological Process: mismatch repair; RNA elongation from RNA polymerase II promoter

Disease: Luscan-lumish Syndrome
 SETD2 ELISA Kit
 SETD2 Recombinant
 SETD2 Antibody
 HIF1 ELISA Kit
 HIF1 Recombinant
 HIF1 Antibody
 HYPB ELISA Kit
 HYPB Recombinant
 HYPB Antibody
 KIAA1732 ELISA Kit
 KIAA1732 Recombinant
 KIAA1732 Antibody
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Histone-lysine N-methyltransferase setd3

 Histone-lysine N-methyltransferase setd3 ELISA Kit
 Histone-lysine N-methyltransferase setd3 Recombinant
 Histone-lysine N-methyltransferase setd3 Antibody
Also known as Histone-lysine N-methyltransferase setd3 (Endothelial differentiation inhibitory protein D10) (SET domain-containing protein 3).
SETD3: Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. Belongs to the SETD3 family. 3 isoforms of the human protein are produced by a
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lternative splicing.

Protein type: EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Cellular Component: nuclear chromatin

Molecular Function: histone lysine N-methyltransferase activity (H3-K36 specific); histone lysine N-methyltransferase activity (H3-K4 specific); transcription coactivator activity

Biological Process: peptidyl-lysine di-methylation; peptidyl-lysine mono-methylation; peptidyl-lysine tri-methylation; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter
 Setd3 ELISA Kit
 Setd3 Recombinant
 Setd3 Antibody
 D12Ertd771e ELISA Kit
 D12Ertd771e Recombinant
 D12Ertd771e Antibody
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Histone-lysine N-methyltransferase SETD7

 Histone-lysine N-methyltransferase SETD7 ELISA Kit
 Histone-lysine N-methyltransferase SETD7 Recombinant
 Histone-lysine N-methyltransferase SETD7 Antibody
Also known as Histone-lysine N-methyltransferase SETD7 (Histone H3-K4 methyltransferase SETD7) (H3-K4-HMTase SETD7) (Lysine N-methyltransferase 7) (SET domain-containing protein 7) (SET7/9).
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histo
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ne proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
 SETD7 ELISA Kit
 SETD7 Recombinant
 SETD7 Antibody
 KIAA1717 ELISA Kit
 KIAA1717 Recombinant
 KIAA1717 Antibody
 KMT7 ELISA Kit
 KMT7 Recombinant
 KMT7 Antibody
 SET7 ELISA Kit
 SET7 Recombinant
 SET7 Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase SETDB1

 Histone-lysine N-methyltransferase SETDB1 ELISA Kit
 Histone-lysine N-methyltransferase SETDB1 Recombinant
 Histone-lysine N-methyltransferase SETDB1 Antibody
Also known as Histone-lysine N-methyltransferase SETDB1 (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1).
SETDB1: a protein lysine methyltransferase that specifically trimethylates K9 of histone H3 (H3K9me3), a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Unlike SUV39H H3K9 methyltransferase, which functions mainly in heterochromatin regions such as pericentric heterochromatin, SETDB1 functions mai
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nly in euchromatic regions, playing a central role in the silencing of euchromatic genes. H3K9me3 is coordinated with DNA methylation. Interacts with a variety of proteins, including transcription factors (ERG), histone deacetylases (HDAC1/2), DNA methyltransferases (DNMT3A/B) and transcriptional co-repressors (mSin3A/B, MBD1, KAP-1, the ATFa-associated modulator mAM). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. Contains Tudor and methyl-CpG-binding domains, which may coordinate binding to methylated histones and methylated DNA, respectively. Is targeted to histone H3 by TIF1B, a factor recruited by KRAB zinc-finger proteins. Recruited by DNMT3A to silenced promoters in cancer cells. May play a role in the pathogenesis of Huntington's disease, since levels of SETDB1 and H3K9me3 are both increased in diseased brains. Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. Three isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cytoplasm; intracellular membrane-bound organelle; nucleoplasm; nucleus; plasma membrane

Molecular Function: chromatin binding; protein binding

Biological Process: Ras protein signal transduction
 SETDB1 ELISA Kit
 SETDB1 Recombinant
 SETDB1 Antibody
 KIAA0067 ELISA Kit
 KIAA0067 Recombinant
 KIAA0067 Antibody
 KMT1E ELISA Kit
 KMT1E Recombinant
 KMT1E Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase SETDB1-A

 Histone-lysine N-methyltransferase SETDB1-A ELISA Kit
 Histone-lysine N-methyltransferase SETDB1-A Recombinant
 Histone-lysine N-methyltransferase SETDB1-A Antibody
Also known as Histone-lysine N-methyltransferase SETDB1-A (SET domain bifurcated 1A).
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a c
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entral role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing ().
 setdb1a ELISA Kit
 setdb1a Recombinant
 setdb1a Antibody
 si:ch211-81a5.6 ELISA Kit
 si:ch211-81a5.6 Recombinant
 si:ch211-81a5.6 Antibody
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Histone-lysine N-methyltransferase SETDB1-B

 Histone-lysine N-methyltransferase SETDB1-B ELISA Kit
 Histone-lysine N-methyltransferase SETDB1-B Recombinant
 Histone-lysine N-methyltransferase SETDB1-B Antibody
Also known as Histone-lysine N-methyltransferase SETDB1-B (SET domain bifurcated 1B).
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a c
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entral role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing ().
 setdb1b ELISA Kit
 setdb1b Recombinant
 setdb1b Antibody
 zgc:152899 ELISA Kit
 zgc:152899 Recombinant
 zgc:152899 Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase SETDB2

 Histone-lysine N-methyltransferase SETDB2 ELISA Kit
 Histone-lysine N-methyltransferase SETDB2 Recombinant
 Histone-lysine N-methyltransferase SETDB2 Antibody
Also known as Histone-lysine N-methyltransferase SETDB2 (Chronic lymphocytic leukemia deletion region gene 8 protein homolog) (SET domain bifurcated 2).
Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits
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HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis ().
 setdb2 ELISA Kit
 setdb2 Recombinant
 setdb2 Antibody
 clld8 ELISA Kit
 clld8 Recombinant
 clld8 Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase SETMAR

 Histone-lysine N-methyltransferase SETMAR ELISA Kit
 Histone-lysine N-methyltransferase SETMAR Recombinant
 Histone-lysine N-methyltransferase SETMAR Antibody
Also known as Histone-lysine N-methyltransferase SETMAR (SET domain and mariner transposase fusion protein homolog).
This gene encodes a histone-lysine N-methyltransferase that may be involved in the methylation of histone H3. In anthropoid primates this gene is a fusion gene of a SET histone-lysine N-methyltransferase and a mariner (MAR) family transposase. In all other species this gene conta
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ins only the SET domain. [provided by RefSeq, Feb 2013]
 SETMAR ELISA Kit
 SETMAR Recombinant
 SETMAR Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase Smyd1

 Histone-lysine N-methyltransferase Smyd1 ELISA Kit
 Histone-lysine N-methyltransferase Smyd1 Recombinant
 Histone-lysine N-methyltransferase Smyd1 Antibody
Also known as Histone-lysine N-methyltransferase Smyd1 (CD8b-opposite) (SET and MYND domain-containing protein 1) (Zinc finger protein BOP) (m-BOP).
SMYD1: Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.

Protein type: EC 2.1.1.43; Methyltransferase, protein lysine; Transcription, coactivator/corepressor

Cellular Component
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: cytoplasm; nucleus

Molecular Function: protein binding; transcription corepressor activity

Biological Process: chromatin remodeling; heart development; negative regulation of transcription, DNA-dependent; positive regulation of myoblast differentiation
 Smyd1 ELISA Kit
 Smyd1 Recombinant
 Smyd1 Antibody
 Bop ELISA Kit
 Bop Recombinant
 Bop Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase SMYD3

 Histone-lysine N-methyltransferase SMYD3 ELISA Kit
 Histone-lysine N-methyltransferase SMYD3 Recombinant
 Histone-lysine N-methyltransferase SMYD3 Antibody
Also known as Histone-lysine N-methyltransferase SMYD3 (SET and MYND domain-containing protein 3) (Zinc finger MYND domain-containing protein 1).
SMYD3: Histone methyltransferase. Specifically methylates 'Lys- 4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences. Belongs to the histone-lysine methyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.1
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.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 1q44

Cellular Component: nucleoplasm

Molecular Function: histone-lysine N-methyltransferase activity
 SMYD3 ELISA Kit
 SMYD3 Recombinant
 SMYD3 Antibody
 ZMYND1 ELISA Kit
 ZMYND1 Recombinant
 ZMYND1 Antibody
 ZNFN3A1 ELISA Kit
 ZNFN3A1 Recombinant
 ZNFN3A1 Antibody
Table BarTOPTable Bar
 

Histone-lysine N-methyltransferase Su

 Histone-lysine N-methyltransferase Su ELISA Kit
 Histone-lysine N-methyltransferase Su Recombinant
 Histone-lysine N-methyltransferase Su Antibody
Also known as Histone-lysine N-methyltransferase Su(var)3-9 (Histone H3-K9 methyltransferase) (H3-K9-HMTase) (Lysine N-methyltransferase 1) (Protein suppressor of variegation 3-9).
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric
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regions. Involved in heterochromatic gene silencing including the modification of position-effect-variegation.
 Su(var)3-9 ELISA Kit
 Su(var)3-9 Recombinant
 Su(var)3-9 Antibody
 KMT1 ELISA Kit
 KMT1 Recombinant
 KMT1 Antibody
 CG6476 ELISA Kit
 CG6476 Recombinant
 CG6476 Antibody
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Histone-lysine N-methyltransferase SUV39H1

 Histone-lysine N-methyltransferase SUV39H1 ELISA Kit
 Histone-lysine N-methyltransferase SUV39H1 Recombinant
 Histone-lysine N-methyltransferase SUV39H1 Antibody
Also known as Histone-lysine N-methyltransferase SUV39H1 (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Lysine N-methyltransferase 1A) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1).
SUV39H1: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histo
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nes. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Interacts with H3 and H4 histones. Interacts with GFI1B, DNMT3B, CBX1, CBX4, KIAA1967/DBC1, MBD1, RUNX1, RUNX3, MYOD1, SMAD5 and RB1. Interacts with SBF1 through the SET domain. Interacts with HDAC1 and HDAC2 through the N-terminus and associates with the core histone deacetylase complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. In case of infection, interacts with HTLV-1 Tax protein, leading to abrogate Tax transactivation of HTLV-1 LTR. Interacts (via SET domain) with MECOM; enhances MECOM transcriptional repression activity. Inhibited by S-adenosyl-L-homocysteine. Negatively regulated by KIAA1967/DBC1. Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily.

Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: chromatin silencing complex; condensed nuclear chromosome; heterochromatin; nucleoplasm; nucleus

Molecular Function: chromatin binding; histone lysine N-methyltransferase activity (H3-K9 specific); histone methyltransferase activity; histone-lysine N-methyltransferase activity; protein binding; protein N-terminus binding; S-adenosylmethionine-dependent methyltransferase activity

Biological Process: chromatin silencing at rDNA; establishment and/or maintenance of chromatin architecture; negative regulation of circadian rhythm; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; response to DNA damage stimulus
 SUV39H1 ELISA Kit
 SUV39H1 Recombinant
 SUV39H1 Antibody
 KMT1A ELISA Kit
 KMT1A Recombinant
 KMT1A Antibody
 SUV39H ELISA Kit
 SUV39H Recombinant
 SUV39H Antibody
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Histone-lysine N-methyltransferase SUV39H1-A

 Histone-lysine N-methyltransferase SUV39H1-A ELISA Kit
 Histone-lysine N-methyltransferase SUV39H1-A Recombinant
 Histone-lysine N-methyltransferase SUV39H1-A Antibody
Also known as Histone-lysine N-methyltransferase SUV39H1-A (Suppressor of variegation 3-9 homolog 1-A) (Su(var)3-9 homolog 1-A).
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Ly
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s-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as regulation of organ-specific terminal differentiation during development.
 suv39h1a ELISA Kit
 suv39h1a Recombinant
 suv39h1a Antibody
 suv39h1 ELISA Kit
 suv39h1 Recombinant
 suv39h1 Antibody
 si:dkey-16n15.2 ELISA Kit
 si:dkey-16n15.2 Recombinant
 si:dkey-16n15.2 Antibody
 zgc:101027 ELISA Kit
 zgc:101027 Recombinant
 zgc:101027 Antibody
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Histone-lysine N-methyltransferase SUV39H2

 Histone-lysine N-methyltransferase SUV39H2 ELISA Kit
 Histone-lysine N-methyltransferase SUV39H2 Recombinant
 Histone-lysine N-methyltransferase SUV39H2 Antibody
Also known as Histone-lysine N-methyltransferase SUV39H2 (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2).
SUV39H2: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag f
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or epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: chromatin; nucleoplasm

Molecular Function: histone lysine N-methyltransferase activity (H3-K9 specific); histone-lysine N-methyltransferase activity; protein binding; zinc ion binding

Biological Process: chromatin assembly or disassembly; chromatin remodeling; negative regulation of circadian rhythm; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
 SUV39H2 ELISA Kit
 SUV39H2 Recombinant
 SUV39H2 Antibody
 KMT1B ELISA Kit
 KMT1B Recombinant
 KMT1B Antibody
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Histone-lysine N-methyltransferase Suv4-20

 Histone-lysine N-methyltransferase Suv4-20 ELISA Kit
 Histone-lysine N-methyltransferase Suv4-20 Recombinant
 Histone-lysine N-methyltransferase Suv4-20 Antibody
Also known as Histone-lysine N-methyltransferase Suv4-20 (SET domain-containing protein 4).
Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression ().
 set-4 ELISA Kit
 set-4 Recombinant
 set-4 Antibody
 CBG02629 ELISA Kit
 CBG02629 Recombinant
 CBG02629 Antibody
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Histone-lysine N-methyltransferase SUVR3

 Histone-lysine N-methyltransferase SUVR3 ELISA Kit
 Histone-lysine N-methyltransferase SUVR3 Recombinant
 Histone-lysine N-methyltransferase SUVR3 Antibody
Also known as Histone-lysine N-methyltransferase SUVR3 (Protein SET DOMAIN GROUP 20) (Suppressor of variegation 3-9-related protein 3) (Su(var)3-9-related protein 3).
Histone methyltransferase.
 SUVR3 ELISA Kit
 SUVR3 Recombinant
 SUVR3 Antibody
 SDG20 ELISA Kit
 SDG20 Recombinant
 SDG20 Antibody
 SET20 ELISA Kit
 SET20 Recombinant
 SET20 Antibody
 At3g03750 ELISA Kit
 At3g03750 Recombinant
 At3g03750 Antibody
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Histone-lysine N-methyltransferase SUVR4

 Histone-lysine N-methyltransferase SUVR4 ELISA Kit
 Histone-lysine N-methyltransferase SUVR4 Recombinant
 Histone-lysine N-methyltransferase SUVR4 Antibody
Also known as Histone-lysine N-methyltransferase SUVR4 (Protein SET DOMAIN GROUP 31) (Suppressor of variegation 3-9-related protein 4) (Su(var)3-9-related protein 4).
Encodes SUVR4, a nucleolar histone methyltransferase with preference for monomethylated H3K9. One of the four closely related Arabidopsis SUVR proteins that belong to the SU(VAR)3-9 subgroup of SET-domain proteins. Proteins containing the evolutionarily conserved SET domain are involved in regulation of eukaryotic gene expression and chromatin structure through their histone lysine methyltransferase (HMTase) activity. SUVR1, S
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UVR2 and SUVR4 proteins contain a novel domain at their N-terminus, and a SUVR specific region preceding the SET domain.
 SUVR4 ELISA Kit
 SUVR4 Recombinant
 SUVR4 Antibody
 SDG31 ELISA Kit
 SDG31 Recombinant
 SDG31 Antibody
 SET31 ELISA Kit
 SET31 Recombinant
 SET31 Antibody
 At3g04380 ELISA Kit
 At3g04380 Recombinant
 At3g04380 Antibody
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Histone-lysine N-methyltransferase SUVR5

 Histone-lysine N-methyltransferase SUVR5 ELISA Kit
 Histone-lysine N-methyltransferase SUVR5 Recombinant
 Histone-lysine N-methyltransferase SUVR5 Antibody
Also known as Histone-lysine N-methyltransferase SUVR5 (C2H2 zinc finger-SET histone methyltransferase) (Protein C2H2 SET) (Protein SET DOMAIN GROUP 6) (Suppressor of variegation 3-9-related protein 5) (Su(var)3-9-related protein 5).
Encodes a SET-domain protein SUVR5 that mediates H3K9me2 deposition and silencing at stimulus response genes in a DNA methylation-independent manner.
 SUVR5 ELISA Kit
 SUVR5 Recombinant
 SUVR5 Antibody
 CZS ELISA Kit
 CZS Recombinant
 CZS Antibody
 SDG6 ELISA Kit
 SDG6 Recombinant
 SDG6 Antibody
 SET6 ELISA Kit
 SET6 Recombinant
 SET6 Antibody
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Histone-lysine N-methyltransferase trithorax

 Histone-lysine N-methyltransferase trithorax ELISA Kit
 Histone-lysine N-methyltransferase trithorax Recombinant
 Histone-lysine N-methyltransferase trithorax Antibody
Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Functions in segment determination through interaction with genes of bithorax (BX-C) and antennapedia (ANT-C) complexes. Acts as an activator of BX-C. Involved in the very early regulation of homeotic genes expressed only in the posterior region o
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f the embryo ().
 trx ELISA Kit
 trx Recombinant
 trx Antibody
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Histone-lysine N-methyltransferase trr

 Histone-lysine N-methyltransferase trr ELISA Kit
 Histone-lysine N-methyltransferase trr Recombinant
 Histone-lysine N-methyltransferase trr Antibody
Also known as Histone-lysine N-methyltransferase trr (Lysine N-methyltransferase 2C) (Trithorax-related protein).
Histone methyltransferase that acts as a coactivator for the ecdysone receptor during development. Specifically trimethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation. Recruited by EcR in an ecdysone-dependent manner causing H3 'Lys-4' trimethylation at ecdysone-inducible promoters, leading to activate expression. Plays a central role in the developing compound eye, during the progression of the morphogenetic furrow and in post-furrow diffe
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rentiation of the retinal epithelium, notably by activating expression of hh. Also required for wing and abdominal development.
 trr ELISA Kit
 trr Recombinant
 trr Antibody
 KMT2C ELISA Kit
 KMT2C Recombinant
 KMT2C Antibody
 CG3848 ELISA Kit
 CG3848 Recombinant
 CG3848 Antibody
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Histone-lysine N-methyltransferase TRX1

 Histone-lysine N-methyltransferase TRX1 ELISA Kit
 Histone-lysine N-methyltransferase TRX1 Recombinant
 Histone-lysine N-methyltransferase TRX1 Antibody
Also known as Histone-lysine N-methyltransferase TRX1 (OsTrx1) (Protein SET DOMAIN GROUP 723) (SET family protein 33) (OsSET33).
Possesses histone H3 methyltransferase activity in vitro (PubMed:24420930). Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Functions as a receptor for the lipid messenger phosphatidylinositol 5-phosphate (PI5P), which regulates negatively its transcriptional activation activity (). Involved in the regulation of flowering time and floral induction under long day (LD) conditions. Acts as
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an activator of flowering under LD conditions. May function through binding to EHD3, a repressor of GHD7 (PubMed:24420930).
 TRX1 ELISA Kit
 TRX1 Recombinant
 TRX1 Antibody
 SDG723 ELISA Kit
 SDG723 Recombinant
 SDG723 Antibody
 SET ELISA Kit
 SET Recombinant
 SET Antibody
 Os09g0134500 ELISA Kit
 Os09g0134500 Recombinant
 Os09g0134500 Antibody
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Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific

 Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific ELISA Kit
 Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific Recombinant
 Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific Antibody
Also known as Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (H4-K20-HMTase) (Lysine N-methyltransferase 3B) (Nuc.
NSD1: Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. Defects in NSD1 are the cause of Sotos syndrome type 1 (SOTOS1); also known as c
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erebral gigantism. It is a disorder characterized by excessively rapid growth, acromegalic features, and a nonprogressive cerebral disorder with mental retardation. High-arched palate and prominent jaw are noted in several patients. Most cases of Sotos syndrome are sporadic and may represent new dominant mutation. Defects in NSD1 are the cause of Weaver syndrome type 1 (WVS1). A syndrome of accelerated growth and osseous maturation, unusual craniofacial appearance, hoarse and low- pitched cry, and hypertonia with camptodactyly. Distinguishing features of Weaver syndrome include broad forehead and face, ocular hypertelorism, prominent wide philtrum, micrognathia, deep horizontal chin groove, and deep-set nails. In addition, carpal bone development is advanced over the rest of the hand. Defects in NSD1 are a cause of Beckwith-Wiedemann syndrome (BWS). BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors. A chromosomal aberration involving NSD1 is found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NUP98. A chromosomal aberration involving NSD1 is found in an adult form of myelodysplastic syndrome (MDS). Insertion of NUP98 into NSD1 generates a NUP98-NSD1 fusion product. Belongs to the histone-lysine methyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: nucleoplasm

Molecular Function: androgen receptor binding; chromatin binding; estrogen receptor binding; histone lysine N-methyltransferase activity (H3-K36 specific); histone lysine N-methyltransferase activity (H4-K20 specific); histone-lysine N-methyltransferase activity; retinoic acid receptor binding; retinoid X receptor binding; thyroid hormone receptor binding; transcription cofactor activity; transcription corepressor activity; zinc ion binding

Biological Process: histone methylation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of histone H3-K36 methylation; regulation of peptidyl-serine phosphorylation

Disease: Beckwith-wiedemann Syndrome; Sotos Syndrome 1
 NSD1 ELISA Kit
 NSD1 Recombinant
 NSD1 Antibody
 ARA267 ELISA Kit
 ARA267 Recombinant
 ARA267 Antibody
 KMT3B ELISA Kit
 KMT3B Recombinant
 KMT3B Antibody
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Histone-lysine N-methyltransferase, H3 lysine-36 specific

 Histone-lysine N-methyltransferase, H3 lysine-36 specific ELISA Kit
 Histone-lysine N-methyltransferase, H3 lysine-36 specific Recombinant
 Histone-lysine N-methyltransferase, H3 lysine-36 specific Antibody
Also known as Histone-lysine N-methyltransferase, H3 lysine-36 specific (Lysine N-methyltransferase 3) (SET domain-containing protein 2).
Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression.
 set2 ELISA Kit
 set2 Recombinant
 set2 Antibody
 kmt3 ELISA Kit
 kmt3 Recombinant
 kmt3 Antibody
 SPAC29B12.02c ELISA Kit
 SPAC29B12.02c Recombinant
 SPAC29B12.02c Antibody
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Histone-lysine N-methyltransferase, H3 lysine-4 specific

 Histone-lysine N-methyltransferase, H3 lysine-4 specific ELISA Kit
 Histone-lysine N-methyltransferase, H3 lysine-4 specific Recombinant
 Histone-lysine N-methyltransferase, H3 lysine-4 specific Antibody
Also known as Histone-lysine N-methyltransferase, H3 lysine-4 specific (COMPASS component SET1) (Lysine N-methyltransferase 2) (SET domain-containing protein 1).
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
 SET1 ELISA Kit
 SET1 Recombinant
 SET1 Antibody
 KMT2 ELISA Kit
 KMT2 Recombinant
 KMT2 Antibody
 YTX1 ELISA Kit
 YTX1 Recombinant
 YTX1 Antibody
 YHR119W ELISA Kit
 YHR119W Recombinant
 YHR119W Antibody
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Histone-lysine N-methyltransferase, H3 lysine-79 specific

 Histone-lysine N-methyltransferase, H3 lysine-79 specific ELISA Kit
 Histone-lysine N-methyltransferase, H3 lysine-79 specific Recombinant
 Histone-lysine N-methyltransferase, H3 lysine-79 specific Antibody
Also known as Histone-lysine N-methyltransferase, H3 lysine-79 specific (Disrupter of telomere silencing protein 1) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4).
Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. Can bind to DNA (in vitro).
 DOT1 ELISA Kit
 DOT1 Recombinant
 DOT1 Antibody
 KMT4 ELISA Kit
 KMT4 Recombinant
 KMT4 Antibody
 PCH1 ELISA Kit
 PCH1 Recombinant
 PCH1 Antibody
 YDR440W ELISA Kit
 YDR440W Recombinant
 YDR440W Antibody
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Histone-lysine N-methyltransferase, H3 lysine-9 specific

 Histone-lysine N-methyltransferase, H3 lysine-9 specific ELISA Kit
 Histone-lysine N-methyltransferase, H3 lysine-9 specific Recombinant
 Histone-lysine N-methyltransferase, H3 lysine-9 specific Antibody
Also known as Histone-lysine N-methyltransferase, H3 lysine-9 specific (Cryptic loci regulator 4) (Histone H3-K9 methyltransferase) (H3-K9-HMTase) (Lysine N-methyltransferase 1).
Histone methyltransferase. Catalytic component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mat
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ing-type loci.
 clr4 ELISA Kit
 clr4 Recombinant
 clr4 Antibody
 kmt1 ELISA Kit
 kmt1 Recombinant
 kmt1 Antibody
 SPBC428.08c ELISA Kit
 SPBC428.08c Recombinant
 SPBC428.08c Antibody
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Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5

 Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5 ELISA Kit
 Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5 Recombinant
 Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5 Antibody
Also known as Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5 (Histone H3-K9 methyltransferase dim-5) (H3-K9-HMTase dim-5) (HKMT).
SETMAR: Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA. 2 i
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soforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine
 dim-5 ELISA Kit
 dim-5 Recombinant
 dim-5 Antibody
 29E8.110 ELISA Kit
 29E8.110 Recombinant
 29E8.110 Antibody
 NCU04402 ELISA Kit
 NCU04402 Recombinant
 NCU04402 Antibody
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Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH1

 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH1 ELISA Kit
 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH1 Recombinant
 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH1 Antibody
Also known as Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH1 (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (NtSet1) (Suppressor of variegation 3-9 homolog protein 1) (Su(var)3-9 homolog protein 1).
Histone methyltransferase. Methylates in vitro both 'Lys-9' and 'Lys-27' of histone H3. Required for in vivo dimethylation of 'Lys-9'. H3 'Lys-9' methylation represents a speci
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fic tag for epigenetic control for plant development and transcriptional repression.
 SUVH1 ELISA Kit
 SUVH1 Recombinant
 SUVH1 Antibody
 SET1 ELISA Kit
 SET1 Recombinant
 SET1 Antibody
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Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH3

 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH3 ELISA Kit
 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH3 Recombinant
 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH3 Antibody
Also known as Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH3 (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Protein SET DOMAIN GROUP 19) (Suppressor of variegation 3-9 homolog protein 3) (Su(var)3-9 homolog protein 3).
Encodes a SU(VAR)3-9 homolog, a SET domain protein. Known SET domain proteins are involved in epigenetic control of gene expression and act as histone methyltransferases. There are 10 SUVH genes in Arabidopsis and members of this subfamily of the SET proteins have an additional conserved SRA domain.
 SUVH3 ELISA Kit
 SUVH3 Recombinant
 SUVH3 Antibody
 SDG19 ELISA Kit
 SDG19 Recombinant
 SDG19 Antibody
 SET19 ELISA Kit
 SET19 Recombinant
 SET19 Antibody
 At1g73100 ELISA Kit
 At1g73100 Recombinant
 At1g73100 Antibody
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Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4

 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 ELISA Kit
 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 Recombinant
 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 Antibody
Also known as Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Protein KRYPTONITE) (Protein SET DOMAIN GROUP 33) (Suppressor of variegation 3-9 homolog protein 4) (Su(var)3-9 homolog prot.
Encodes a histone 3 lysine 9 specific methyltransferase involved in the maintenance of DNA methylation. SUVH4/KYP is a SU(VAR)3-9 homolog, a SET domain protein. Known SET domain proteins are involved in epigenetic control of gene expression. There are 10 SUVH genes in Arabidopsis and members of this subfamily of the SET proteins have an a
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dditional conserved SRA domain. In kyp mutants, there is a loss of CpNpG methylation. The protein was shown to bind to methylated cytosines of CG, CNG and CNN motifs via its SRA domain but has a preference for the latter two. There is also evidence that KYP/SUVH4 might be involved in the telomerase-independent process known as Alternative Lengthening of Telomeres.
 SUVH4 ELISA Kit
 SUVH4 Recombinant
 SUVH4 Antibody
 KYP ELISA Kit
 KYP Recombinant
 KYP Antibody
 SDG33 ELISA Kit
 SDG33 Recombinant
 SDG33 Antibody
 SET33 ELISA Kit
 SET33 Recombinant
 SET33 Antibody
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Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5

 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5 ELISA Kit
 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5 Recombinant
 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5 Antibody
Also known as Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5 (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Protein SET DOMAIN GROUP 9) (Suppressor of variegation 3-9 homolog protein 5) (Su(var)3-9 homolog protein 5).
Encodes SU(var)3-9 homologue 5 (SUVH5). SUVH5 has histone methyltransferase (MTase) activity in vitro and contributes to the maintenance of H3 mK9 (methylation of histone H3 at Lys-9) and CMT3-mediated non-CG methylation in vivo. This is a member of a subfamily of SET proteins that shares a conserved SRA domain.
 SUVH5 ELISA Kit
 SUVH5 Recombinant
 SUVH5 Antibody
 SDG9 ELISA Kit
 SDG9 Recombinant
 SDG9 Antibody
 SET9 ELISA Kit
 SET9 Recombinant
 SET9 Antibody
 At2g35160 ELISA Kit
 At2g35160 Recombinant
 At2g35160 Antibody
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Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6

 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6 ELISA Kit
 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6 Recombinant
 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6 Antibody
Also known as Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6 (Histone H3-K9 methyltransferase 6) (H3-K9-HMTase 6) (Protein SET DOMAIN GROUP 23) (Suppressor of variegation 3-9 homolog protein 6) (Su(var)3-9 homolog protein 6).
Encodes a SU(VAR)3-9 homolog, a methyltransferase involved in histone methylation. The protein was shown to bind to methylated cytosines of CG, CNG and CNN motifs but has a preference for the latter two. This is a member of a subfamily of SET proteins that shares a conserved SRA domain.
 SUVH6 ELISA Kit
 SUVH6 Recombinant
 SUVH6 Antibody
 SDG23 ELISA Kit
 SDG23 Recombinant
 SDG23 Antibody
 SET23 ELISA Kit
 SET23 Recombinant
 SET23 Antibody
 At2g22740 ELISA Kit
 At2g22740 Recombinant
 At2g22740 Antibody
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Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7

 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7 ELISA Kit
 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7 Recombinant
 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7 Antibody
Also known as Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7 (Histone H3-K9 methyltransferase 7) (H3-K9-HMTase 7) (Protein SET DOMAIN GROUP 17) (Suppressor of variegation 3-9 homolog protein 7) (Su(var)3-9 homolog protein 7).
Encodes a SU(VAR)3-9 homolog, a SET domain protein. Known SET domain proteins are involved in epigenetic control of gene expression and act as histone methyltransferases. There are 10 SUVH genes in Arabidopsis and members of this subfamily of the SET proteins have an additional conserved SRA domain. A paternally expressed imprinted gene.
 SUVH7 ELISA Kit
 SUVH7 Recombinant
 SUVH7 Antibody
 SDG17 ELISA Kit
 SDG17 Recombinant
 SDG17 Antibody
 SET17 ELISA Kit
 SET17 Recombinant
 SET17 Antibody
 At1g17770 ELISA Kit
 At1g17770 Recombinant
 At1g17770 Antibody
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Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH8

 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH8 ELISA Kit
 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH8 Recombinant
 Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH8 Antibody
Also known as Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH8 (Histone H3-K9 methyltransferase 8) (H3-K9-HMTase 8) (Protein SET DOMAIN GROUP 21) (Suppressor of variegation 3-9 homolog protein 8) (Su(var)3-9 homolog protein 8).
Encodes a SU(VAR)3-9 homolog, a SET domain protein (Homology Subgroup V; Orthology Group 1). Known SET domain proteins are involved in epigenetic control of gene expression. There are 10 SUVH genes in Arabidopsis and members of this subfamily of the SET proteins have an additional conserved SRA domain. This protein is a putative histone methyltransferas
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e (predicted to methylate H3K9/20) related to the the Drosophila Su(var)3-9 and mammalian G9a proteins.
 SUVH8 ELISA Kit
 SUVH8 Recombinant
 SUVH8 Antibody
 SDG21 ELISA Kit
 SDG21 Recombinant
 SDG21 Antibody
 SET21 ELISA Kit
 SET21 Recombinant
 SET21 Antibody
 At2g24740 ELISA Kit
 At2g24740 Recombinant
 At2g24740 Antibody
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