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HMG-CoA reductase inhibitor bumarsin ELISA Kit HMG-CoA reductase inhibitor bumarsin Recombinant HMG-CoA reductase inhibitor bumarsin Antibody | Also known as HMG-CoA reductase inhibitor bumarsin (JCH2) (Lipolysis-activating peptide 1-beta chain) (BmLVP1-beta) (LVP1-beta) (Neurotoxin KITx) (BmKITx) (Putative toxin BmKTXLP2). The homodimer ( >>> PubMed:22575281) inhibits HMG-CoA reductase (HMGCR) (32% of inhibition produced by 0.6 µM), a glycoprotein involved in the control of cholesterol biosynthesis. The inhibitory effects of bumarsin are seen at much lower concentrations (0.6 µM) than that for statins such as atorvastatin (5 mM) and simvastatin (10 µM). In addition to inhibition of HMG-CoA reductase, this protein lowers cholesterol levels by inducing steroid hormone synthesis via StAR, and by increasing reverse cholesterol transport mediated by the induction of ABCA1 and APOA1. |
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