HMG-CoA reductase inhibitor

PubMed:22575281) inhibits HMG-CoA reductase (HMGCR) (32% of inhibition produced by 0.6 µM), a glycoprotein involved in the control of cholesterol biosynthesis. The inhibitory effects of bumarsin are seen at much lower concentrations (0.6 µM) than that for statins such as atorvastatin (5 mM) and simvastatin (10 µM). In addition to inhibition of HMG-CoA reductase, this protein lowers cholesterol levels by inducing steroid hormone synthesis via StAR, and by increasing reverse cholesterol transport mediated by the induction of ABCA1 and APOA1.