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HORMA domain-containing protein

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Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.

Below are the list of possible HORMA domain-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

HORMA domain-containing protein 1

 HORMA domain-containing protein 1 ELISA Kit
 HORMA domain-containing protein 1 Recombinant
 HORMA domain-containing protein 1 Antibody
HORMAD1: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the ma
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le mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cancer Testis Antigen (CTA)

Cellular Component: chromosome; condensed nuclear chromosome; nucleus; synaptonemal complex

Biological Process: blastocyst development; meiosis; meiotic DNA double-strand break formation; meiotic recombination checkpoint; meiotic sister chromatid cohesion; oogenesis; spermatogenesis; synapsis; synaptonemal complex assembly
 Hormad1 ELISA Kit
 Hormad1 Recombinant
 Hormad1 Antibody
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HORMA domain-containing protein 2

 HORMA domain-containing protein 2 ELISA Kit
 HORMA domain-containing protein 2 Recombinant
 HORMA domain-containing protein 2 Antibody
Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality contr
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ol in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation ().
 HORMAD2 ELISA Kit
 HORMAD2 Recombinant
 HORMAD2 Antibody
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