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Huntingtin-interacting protein

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Plays a role in clathrin-mediated endocytosis and trafficking .

Below are the list of possible Huntingtin-interacting protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Huntingtin-interacting protein 1

 Huntingtin-interacting protein 1 ELISA Kit
 Huntingtin-interacting protein 1 Recombinant
 Huntingtin-interacting protein 1 Antibody
Also known as Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I).
HIP1: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acti
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ng through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors. A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed. Belongs to the SLA2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cytoskeletal

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: AP-2 adaptor complex; clathrin-coated vesicle; cytoplasm; cytoskeleton; Golgi apparatus; intracellular membrane-bound organelle; membrane; nucleus

Molecular Function: actin filament binding; clathrin binding; clathrin light chain binding; epidermal growth factor receptor binding; glutamate receptor binding; phosphatidylinositol 3-phosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; phosphoinositide binding; protein binding; protein heterodimerization activity; protein homodimerization activity; structural constituent of cytoskeleton

Biological Process: apoptosis; caspase activation; clathrin cage assembly; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of protein kinase B signaling cascade; positive regulation of receptor-mediated endocytosis; protein stabilization; regulation of apoptosis

Disease: Prostate Cancer
 HIP1 ELISA Kit
 HIP1 Recombinant
 HIP1 Antibody
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Huntingtin-interacting protein K

 Huntingtin-interacting protein K ELISA Kit
 Huntingtin-interacting protein K Recombinant
 Huntingtin-interacting protein K Antibody
Also known as Huntingtin-interacting protein K (Huntingtin yeast partner K).
Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in neuronal cells. Required for optimal NAA10-NAA15 complex-mediated N-terminal acetylation ().
 HYPK ELISA Kit
 HYPK Recombinant
 HYPK Antibody
 QnpA-10575 ELISA Kit
 QnpA-10575 Recombinant
 QnpA-10575 Antibody
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Huntingtin-interacting protein M

 Huntingtin-interacting protein M ELISA Kit
 Huntingtin-interacting protein M Recombinant
 Huntingtin-interacting protein M Antibody
Also known as Huntingtin-interacting protein M (Huntingtin yeast partner M).
HYPM: May interact with the N-terminus of HD.

Cellular Component: nuclear chromatin

Molecular Function: DNA binding

Biological Process: chromatin silencing
 Hypm ELISA Kit
 Hypm Recombinant
 Hypm Antibody
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