Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Protein Family  rightarrow Hydroperoxide isomerase  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Progranulin (PGRN) Recombinant Protein
 • Voltage-dependent L-type calcium channel subunit alpha-1F (C... Recombinant Protein
 • UDP-GlcNAc:betaGal beta-1, 3-N-acetylglucosaminyltrans ferase... ELISA Kit
 • FA13A Antibody
 • Smac (Diablo) Blocking Peptide
 • Interferon Gamma Receptor 1 (IFNgR1) Antibody
 • FABP4  Antibody
 • AQP-4 ELISA Kit
 • ADH1B Antibody
 • S100 Calcium Binding Protein B (S100B) Antibody
 • programmed cell death 6 interacting protein (PDCD6IP) ELISA Kit
 • Acetylcholinesterase (AChE) ELISA Kit
 • HIV1 gp41 Antibody
 • KCNN4 Antibody
 downarrow more ...
separator

Hydroperoxide isomerase

separator
Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia.

Below are the list of possible Hydroperoxide isomerase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Hydroperoxide isomerase ALOXE3

 Hydroperoxide isomerase ALOXE3 ELISA Kit
 Hydroperoxide isomerase ALOXE3 Recombinant
 Hydroperoxide isomerase ALOXE3 Antibody
Also known as Hydroperoxide isomerase ALOXE3 (Epidermis-type lipoxygenase 3) (Epidermal LOX-3) (e-LOX-3) (eLOX-3) (Hydroperoxy icosatetraenoate dehydratase).
ALOXE3: Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known. Defects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE). NCIE is a non- bullous ichthyosis, a skin disord
>>>
er characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume. Belongs to the lipoxygenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 4.2.1.152; EC 5.4.4.7; Oxidoreductase

Molecular Function: catalytic activity; hepoxilin A3 synthase activity

Biological Process: arachidonic acid metabolic process; ceramide biosynthetic process; epidermis development; fat cell differentiation; hepoxilin biosynthetic process; linoleic acid metabolic process; lipoxygenase pathway; sensory perception of pain; sphingolipid metabolic process
 Aloxe3 ELISA Kit
 Aloxe3 Recombinant
 Aloxe3 Antibody
Table BarTOPTable Bar
Proteins Root Name Listing
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions