Hydroxyacid-oxoacid transhydrogenase

Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity).

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Hydroxyacid-oxoacid transhydrogenase
Hydroxyacid-oxoacid transhydrogenase ELISA Kit Hydroxyacid-oxoacid transhydrogenase Recombinant Hydroxyacid-oxoacid transhydrogenase Antibody		Also known as Hydroxyacid-oxoacid transhydrogenase, mitochondrial (HOT) (Alcohol dehydrogenase iron-containing protein 1) (ADHFe1). ADHFE1: Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OH >>> B) are also substrates for HOT with 10-fold lower activities. Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. 4 isoforms of the human protein are produced by alternative splicing. Protein type: EC 1.1.99.24; Mitochondrial; Oxidoreductase Cellular Component: mitochondrion Molecular Function: hydroxyacid-oxoacid transhydrogenase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Biological Process: molecular hydrogen transport
Adhfe1 ELISA Kit Adhfe1 Recombinant Adhfe1 Antibody

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