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Hydroxyacid-oxoacid transhydrogenase

Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity).

Below are the list of possible Hydroxyacid-oxoacid transhydrogenase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Hydroxyacid-oxoacid transhydrogenase

 Hydroxyacid-oxoacid transhydrogenase ELISA Kit
 Hydroxyacid-oxoacid transhydrogenase Recombinant
 Hydroxyacid-oxoacid transhydrogenase Antibody
Also known as Hydroxyacid-oxoacid transhydrogenase, mitochondrial (HOT) (Alcohol dehydrogenase iron-containing protein 1) (ADHFe1).
ADHFE1: Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OH
B) are also substrates for HOT with 10-fold lower activities. Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC; Mitochondrial; Oxidoreductase

Cellular Component: mitochondrion

Molecular Function: hydroxyacid-oxoacid transhydrogenase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Biological Process: molecular hydrogen transport
 Adhfe1 ELISA Kit
 Adhfe1 Recombinant
 Adhfe1 Antibody
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