Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Protein Family  rightarrow Hypermethylated in cancer 1 protein  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Clostridium difficile Toxin A Antibody
 • Interferon Alpha 2 (IFNalpha2) ELISA Kit
 • Epilepsy, Progressive Myoclonus Type 2A (EPM2A) Antibody
 • Platelet-Endothelial Cell Adhesion Molecule (PECAM1) Antibody
 • 2,3-dihydro-2,3-dihydroxybe nzoate dehydrogenase (dhbA) Recombinant Protein
 • Caspase 3 (CASP3) ELISA Kit
 • acyl-CoA synthetase short-chain family member 3 (ACSS3) ELISA Kit
 • Transforming Growth Factor beta (TGFbeta) ELISA Kit
 • HCV-NS5b Recombinant Protein
 • Choline acetyltransferase (ChAT) ELISA Kit
 • Asc-type amino acid transporter 1 (SLC7A10) ELISA Kit
 • NRAS - N-ras Antibody
 • Thyroid Hormone Receptor alpha (THRA) Antibody
 • Nucleobindin-2 (NUCB2) Recombinant Protein
 downarrow more ...
separator

Hypermethylated in cancer 1 protein

separator
Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.

Below are the list of possible Hypermethylated in cancer 1 protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Hypermethylated in cancer 1 protein

 Hypermethylated in cancer 1 protein ELISA Kit
 Hypermethylated in cancer 1 protein Recombinant
 Hypermethylated in cancer 1 protein Antibody
Also known as Hypermethylated in cancer 1 protein (Hic-1).
HIC1: Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage respo
>>>
nses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF- responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from CXCR7, FGFBP1 and EFNA1. Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; Transcription factor; Tumor suppressor

Cellular Component: chromatin; cytoplasm; nucleoplasm

Molecular Function: histone deacetylase binding; sequence-specific DNA binding; transcription factor activity

Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of Wnt receptor signaling pathway; positive regulation of DNA damage response, signal transduction by p53 class mediator
 Hic1 ELISA Kit
 Hic1 Recombinant
 Hic1 Antibody
Table BarTOPTable Bar
Proteins Root Name Listing
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions