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Hypoxia-inducible factor

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A transcription factor which is a key regulator in various cellular processes; including environment stress resistance (oxygen levels, hydrogen sulfide and cyanide levels and heat), negative regulation of cell apoptosis in ASJ neurons by inhibition of cep-1 via transcriptional activation of tyr-2, resistance/susceptibility to pathogenic bacteria, lifespan and brood size .

Below are the list of possible Hypoxia-inducible factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Hypoxia-inducible factor 1

 Hypoxia-inducible factor 1 ELISA Kit
 Hypoxia-inducible factor 1 Recombinant
 Hypoxia-inducible factor 1 Antibody
Also known as Hypoxia-inducible factor 1 (Hypoxia-induced factor 1).
A transcription factor which is a key regulator in various cellular processes; including environment stress resistance (oxygen levels, hydrogen sulfide and cyanide levels and heat), negative regulation of cell apoptosis in ASJ neurons by inhibition of cep-1 via transcriptional activation of tyr-2, resistance/susceptibility to
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pathogenic bacteria, lifespan and brood size (PubMed:11427734, PubMed:12006646, PubMed:12686697, PubMed:15781453, PubMed:18477695, PubMed:19461873, PubMed:21093262, PubMed:19889840, PubMed:20520707, PubMed:20400959). Involved in mediating susceptibility to enteropathogenic E.coli (PubMed:16091039). Increased levels of hif-1 activity confer resistance to P.aeruginosa-mediated death but also confer susceptibility to S.aureus infection (PubMed:20865124, PubMed:22792069). Required for aha-1 nuclear localization (PubMed:11427734). Following hypoxic stress, up-regulates serotonin levels through activation of tph-1 expression (PubMed:20400959). Role in life span extension is dependent of temperature (PubMed:21241450). Not required for survival in anoxic conditions (PubMed:11427734). Involved in iron homeostasis by repressing transcription of ferritin ftn-1 and ftn-2, and divalent metal transporter smf-3 (PubMed:22396654, PubMed:22194696). May be involved in manganese homeostasis by repressing divalent metal transporter smf-3 (PubMed:22194696).
 hif-1 ELISA Kit
 hif-1 Recombinant
 hif-1 Antibody
 F38A6.3 ELISA Kit
 F38A6.3 Recombinant
 F38A6.3 Antibody
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Hypoxia-inducible factor 1-alpha

 Hypoxia-inducible factor 1-alpha ELISA Kit
 Hypoxia-inducible factor 1-alpha Recombinant
 Hypoxia-inducible factor 1-alpha Antibody
Also known as Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha).
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxyge
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n delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia ().
 HIF1A ELISA Kit
 HIF1A Recombinant
 HIF1A Antibody
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Hypoxia-inducible factor 3-alpha

 Hypoxia-inducible factor 3-alpha ELISA Kit
 Hypoxia-inducible factor 3-alpha Recombinant
 Hypoxia-inducible factor 3-alpha Antibody
Also known as Hypoxia-inducible factor 3-alpha (HIF-3-alpha) (HIF3-alpha) (Basic-helix-loop-helix-PAS protein MOP7) (Class E basic helix-loop-helix protein 17) (bHLHe17) (HIF3-alpha-1) (Inhibitory PAS domain protein) (IPAS) (Member of PAS protein 7) (PAS domain-containing protein 7).
HIF3A: Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1. Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 4 h
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as a dominant-negative function of inactivating HIF1A-mediated transcription. Isoform 4 attenuates the binding of HIF1A to hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of isoform 4, leading to activation of HIF1A in hypoxia. Conversely, upon restoring normoxia, the expression of isoform 4 increases and thereby secure an inhibition of HIF1A activity. Isoform 4 may be a negative regulator of hypoxia-inducible gene expression in the kidney and may be involved in renal tumorigenesis. Functions as an inhibitor of angiogenesis in the cornea. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Tumor suppressor

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: cytosol; nucleoplasm

Biological Process: positive regulation of transcription from RNA polymerase II promoter
 HIF3A ELISA Kit
 HIF3A Recombinant
 HIF3A Antibody
 BHLHE17 ELISA Kit
 BHLHE17 Recombinant
 BHLHE17 Antibody
 MOP7 ELISA Kit
 MOP7 Recombinant
 MOP7 Antibody
 PASD7 ELISA Kit
 PASD7 Recombinant
 PASD7 Antibody
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