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Importin

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Export receptor for importin alpha (SRP1). Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm.

Below are the list of possible Importin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Importin alpha re-exporter

 Importin alpha re-exporter ELISA Kit
 Importin alpha re-exporter Recombinant
 Importin alpha re-exporter Antibody
Also known as Importin alpha re-exporter (Chromosome segregation protein CSE1).
Export receptor for importin alpha (SRP1). Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm.
 CSE1 ELISA Kit
 CSE1 Recombinant
 CSE1 Antibody
 YGL238W ELISA Kit
 YGL238W Recombinant
 YGL238W Antibody
 HRC135 ELISA Kit
 HRC135 Recombinant
 HRC135 Antibody
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Importin beta SMX1

 Importin beta SMX1 ELISA Kit
 Importin beta SMX1 Recombinant
 Importin beta SMX1 Antibody
Also known as Importin beta SMX1 (Suppressor of mRNA export mutant protein 1) (karyopherin-108).
Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm. Required for the nuclear import of ribosomal proteins (RPL11, RPL16, RPL25, RPL31A), the poly(A)-binding protein PAB1, the HO endonuclease or the tRNA and snRNA chaperone LHP1. Indirectly involved in nuclear mRNA export through its PAB1 nuclear import activity.
 SXM1 ELISA Kit
 SXM1 Recombinant
 SXM1 Antibody
 KAP108 ELISA Kit
 KAP108 Recombinant
 KAP108 Antibody
 YDR395W ELISA Kit
 YDR395W Recombinant
 YDR395W Antibody
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Importin beta-like SAD2

 Importin beta-like SAD2 ELISA Kit
 Importin beta-like SAD2 Recombinant
 Importin beta-like SAD2 Antibody
Also known as Importin beta-like SAD2 (Protein ENHANCED MIRNA ACTIVITY 1) (Protein SUPER SENSITIVE TO ABA AND DROUGHT 2) (Protein UNARMED 9).
SAD2 (super sensitive to ABA and drought 2) encodes an importin beta-domain family protein likely to be involved in nuclear transport in ABA signaling. Subcellular localization of GFP-tagged SAD2 showed a predominantly nuclear localization, consistent with a role for SAD2 in nuclear transport. Mutation of SAD2 in Arabidopsis alters abscisic acid sensitivity. SAD2 was ubiquitously expressed at low levels in all tissues except flowers. SAD2 expression w
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as not induced by ABA or stress. Loss of function mutations in SAD2 exhibit increased tolerance for UV stress, increased production of UV protective secondary metabolites and suppression of nuclear localization of MYB4 (a repressor of UV stress response genes). Regulates microRNA activity.
 SAD2 ELISA Kit
 SAD2 Recombinant
 SAD2 Antibody
 EMA1 ELISA Kit
 EMA1 Recombinant
 EMA1 Antibody
 URM9 ELISA Kit
 URM9 Recombinant
 URM9 Antibody
 At2g31660 ELISA Kit
 At2g31660 Recombinant
 At2g31660 Antibody
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Importin beta-like SAD2 homolog

 Importin beta-like SAD2 homolog ELISA Kit
 Importin beta-like SAD2 homolog Recombinant
 Importin beta-like SAD2 homolog Antibody
Functions probably in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with other importin subunits.
 At3g59020 ELISA Kit
 At3g59020 Recombinant
 At3g59020 Antibody
 F17J16.70 ELISA Kit
 F17J16.70 Recombinant
 F17J16.70 Antibody
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Importin subunit alpha

 Importin subunit alpha ELISA Kit
 Importin subunit alpha Recombinant
 Importin subunit alpha Antibody
Also known as Importin subunit alpha (Karyopherin alpha).
Import of proteins with classical NLS composed of one or two clusters of basic residues is initiated by binding to the importin alpha/beta heterodimer, where importin alpha acts as an adapter subunit to bridge NLS cargos to importin beta, which transports the whole complex through the nuclear envelope (). Involved in the nuclear accumula
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tion of the light-dependent developmental regulator velA (PubMed:20543063).
 kapA ELISA Kit
 kapA Recombinant
 kapA Antibody
 Pc21g01970 ELISA Kit
 Pc21g01970 Recombinant
 Pc21g01970 Antibody
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Importin subunit alpha-1

 Importin subunit alpha-1 ELISA Kit
 Importin subunit alpha-1 Recombinant
 Importin subunit alpha-1 Antibody
Also known as Importin subunit alpha-1 (Cell untimely torn protein 15) (Karyopherin subunit alpha-1) (Serine-rich RNA polymerase I suppressor protein).
Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs. Has an
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essential role in mitotic chromosome condensation. Involved in nuclear protein import. Required for efficient nuclear import of both an SV40 nuclear localization signal-containing reporter protein and the pap1 component of the stress response MAP kinase pathway. Required for proper mitotic progression.
 cut15 ELISA Kit
 cut15 Recombinant
 cut15 Antibody
 SPCC962.03c ELISA Kit
 SPCC962.03c Recombinant
 SPCC962.03c Antibody
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Importin subunit alpha-1a

 Importin subunit alpha-1a ELISA Kit
 Importin subunit alpha-1a Recombinant
 Importin subunit alpha-1a Antibody
Functions in nuclear protein import. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope.
 Os01g0253300 ELISA Kit
 Os01g0253300 Recombinant
 Os01g0253300 Antibody
 LOC_Os01g14950 ELISA Kit
 LOC_Os01g14950 Recombinant
 LOC_Os01g14950 Antibody
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Importin subunit alpha-1b

 Importin subunit alpha-1b ELISA Kit
 Importin subunit alpha-1b Recombinant
 Importin subunit alpha-1b Antibody
Functions in nuclear protein import. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. In conjunction with importin beta-1, mediates the nuclear envelope docking, and the subsequent translocation into the nucleus of the constitutive morphogenetic 1 (COP1) protein containing bipartite NLS m
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otif.
 Os05g0155601 ELISA Kit
 Os05g0155601 Recombinant
 Os05g0155601 Antibody
 LOC_Os05g06350 ELISA Kit
 LOC_Os05g06350 Recombinant
 LOC_Os05g06350 Antibody
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Importin subunit alpha-2

 Importin subunit alpha-2 ELISA Kit
 Importin subunit alpha-2 Recombinant
 Importin subunit alpha-2 Antibody
Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope.
 Os01g0158000 ELISA Kit
 Os01g0158000 Recombinant
 Os01g0158000 Antibody
 LOC_Os01g06470 ELISA Kit
 LOC_Os01g06470 Recombinant
 LOC_Os01g06470 Antibody
 P0011G08.44 ELISA Kit
 P0011G08.44 Recombinant
 P0011G08.44 Antibody
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Importin subunit alpha-3

 Importin subunit alpha-3 ELISA Kit
 Importin subunit alpha-3 Recombinant
 Importin subunit alpha-3 Antibody
Also known as Importin subunit alpha-3 (IMPa-3) (Karyopherin subunit alpha-2) (KAP-alpha-2) (Protein MODIFIER OF SNC1 6).
Encodes IMPORTIN ALPHA 3. Mutant plants act as suppressors of snc1 response and salicylic acid accumulation. Located in the nucleus. Involved in protein import. Protein interacts with Agrobacterium proteins VirD2 and VirE2. Is not individually essential for Agrobacterium-mediated root transformation, but when overexpressed can rescue the impa-4 decreased transformation susceptibility phenotype.
 IMPA3 ELISA Kit
 IMPA3 Recombinant
 IMPA3 Antibody
 KAP2 ELISA Kit
 KAP2 Recombinant
 KAP2 Antibody
 MOS6 ELISA Kit
 MOS6 Recombinant
 MOS6 Antibody
 At4g02150 ELISA Kit
 At4g02150 Recombinant
 At4g02150 Antibody
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Importin subunit alpha-4

 Importin subunit alpha-4 ELISA Kit
 Importin subunit alpha-4 Recombinant
 Importin subunit alpha-4 Antibody
Also known as Importin subunit alpha-4 (IMPa-4).
Protein interacts with Agrobacterium proteins VirD2 and VirE2.
 IMPA4 ELISA Kit
 IMPA4 Recombinant
 IMPA4 Antibody
 At1g09270 ELISA Kit
 At1g09270 Recombinant
 At1g09270 Antibody
 T12M4.2 ELISA Kit
 T12M4.2 Recombinant
 T12M4.2 Antibody
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Importin subunit alpha-5

 Importin subunit alpha-5 ELISA Kit
 Importin subunit alpha-5 Recombinant
 Importin subunit alpha-5 Antibody
Also known as Importin subunit alpha-5 (IMPa-5) (Importin subunit alpha).
Putative importin alpha isoform. When overexpressed can rescue the impa-4 decreased transformation susceptibility phenotype.
 IMPA5 ELISA Kit
 IMPA5 Recombinant
 IMPA5 Antibody
 At5g49310 ELISA Kit
 At5g49310 Recombinant
 At5g49310 Antibody
 K21P3.21 ELISA Kit
 K21P3.21 Recombinant
 K21P3.21 Antibody
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Importin subunit alpha-6

 Importin subunit alpha-6 ELISA Kit
 Importin subunit alpha-6 Recombinant
 Importin subunit alpha-6 Antibody
Also known as Importin subunit alpha-6 (IMPa-6).
Putative importin alpha isoform. When overexpressed can rescue the impa-4 decreased transformation susceptibility phenotype.
 IMPA6 ELISA Kit
 IMPA6 Recombinant
 IMPA6 Antibody
 At1g02690 ELISA Kit
 At1g02690 Recombinant
 At1g02690 Antibody
 T14P4.3 ELISA Kit
 T14P4.3 Recombinant
 T14P4.3 Antibody
Table BarTOPTable Bar
 

Importin subunit alpha-7

 Importin subunit alpha-7 ELISA Kit
 Importin subunit alpha-7 Recombinant
 Importin subunit alpha-7 Antibody
Also known as Importin subunit alpha-7 (IMPa-7).
Putative importin alpha isoform. When overexpressed can rescue the impa-4 decreased transformation susceptibility phenotype.
 IMPA7 ELISA Kit
 IMPA7 Recombinant
 IMPA7 Antibody
 At3g05720 ELISA Kit
 At3g05720 Recombinant
 At3g05720 Antibody
 F18C1.1 ELISA Kit
 F18C1.1 Recombinant
 F18C1.1 Antibody
Table BarTOPTable Bar
 

Importin subunit alpha-8

 Importin subunit alpha-8 ELISA Kit
 Importin subunit alpha-8 Recombinant
 Importin subunit alpha-8 Antibody
Also known as Importin subunit alpha-8 (IMPa-8).
Putative importin alpha isoform. When overexpressed can rescue the impa-4 decreased transformation susceptibility phenotype. Target promoter of the male germline-specific transcription factor DUO1.
 IMPA8 ELISA Kit
 IMPA8 Recombinant
 IMPA8 Antibody
 At5g52000 ELISA Kit
 At5g52000 Recombinant
 At5g52000 Antibody
 MSG15.8 ELISA Kit
 MSG15.8 Recombinant
 MSG15.8 Antibody
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Importin subunit alpha-9

 Importin subunit alpha-9 ELISA Kit
 Importin subunit alpha-9 Recombinant
 Importin subunit alpha-9 Antibody
Also known as Importin subunit alpha-9 (IMPa-9).
Putative importin alpha isoform. When overexpressed can rescue the impa-4 decreased transformation susceptibility phenotype.
 IMPA9 ELISA Kit
 IMPA9 Recombinant
 IMPA9 Antibody
 At5g03070 ELISA Kit
 At5g03070 Recombinant
 At5g03070 Antibody
 F15A17.100 ELISA Kit
 F15A17.100 Recombinant
 F15A17.100 Antibody
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Importin subunit alpha-B

 Importin subunit alpha-B ELISA Kit
 Importin subunit alpha-B Recombinant
 Importin subunit alpha-B Antibody
Also known as Importin subunit alpha-B (Karyopherin subunit alpha-B).
Functions in nuclear protein import via a substrate-importin alpha-beta transport complex that passes though the nuclear pore complexes (NPC). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif ().
 DDB_G0272318 ELISA Kit
 DDB_G0272318 Recombinant
 DDB_G0272318 Antibody
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Importin subunit beta

 Importin subunit beta ELISA Kit
 Importin subunit beta Recombinant
 Importin subunit beta Antibody
Also known as Importin subunit beta (Importin-90) (Karyopherin subunit beta) (p97).
Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.
 kpnb1 ELISA Kit
 kpnb1 Recombinant
 kpnb1 Antibody
Table BarTOPTable Bar
 

Importin subunit beta-1

 Importin subunit beta-1 ELISA Kit
 Importin subunit beta-1 Recombinant
 Importin subunit beta-1 Antibody
Also known as Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97).
KPNB1: a nuclear import protein nuclear protein import that functions either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomou
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s nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re- exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports PRKCI into the nucleus. Forms a complex with an importin alpha subunit. Forms a heterodimer with IPO7. Interacts with IPO7, SNUPN, RPL23A and XPO1. Two isoforms of the human protein have been reported. Belongs to the importin beta family.

Protein type: Karyopherin; Nuclear import

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: cytoplasm; cytosol; membrane; nuclear envelope; nuclear membrane; nuclear pore; nucleoplasm

Molecular Function: enzyme binding; nuclear localization sequence binding; protein binding; protein domain specific binding; protein transporter activity; zinc ion binding

Biological Process: astral microtubule organization and biogenesis; DNA fragmentation during apoptosis; establishment of mitotic spindle localization; establishment of protein localization; mitotic chromosome movement towards spindle pole; mitotic metaphase plate congression; modification by virus of host cellular process; NLS-bearing substrate import into nucleus; protein import into nucleus; protein import into nucleus, docking; protein import into nucleus, translocation; Ran protein signal transduction; ribosomal protein import into nucleus
 KPNB1 ELISA Kit
 KPNB1 Recombinant
 KPNB1 Antibody
 NTF97 ELISA Kit
 NTF97 Recombinant
 NTF97 Antibody
Table BarTOPTable Bar
 

Importin subunit beta-2

 Importin subunit beta-2 ELISA Kit
 Importin subunit beta-2 Recombinant
 Importin subunit beta-2 Antibody
Also known as Importin subunit beta-2 (Importin-104) (Karyopherin subunit beta-2) (Karyopherin-104) (Transportin) (TRN).
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Required for nuclear transport of NAB2, HRP1/NAB4 and TFG2. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins (PubMed:8849456, PubMed:9488461,
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PubMed:10506153, PubMed:19366694). The complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11423015). At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of the cargo. Efficient GTP-Ran-mediated substrate release requires RNA (PubMed:10506153). The importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11423015).
 KAP104 ELISA Kit
 KAP104 Recombinant
 KAP104 Antibody
 YBR017C ELISA Kit
 YBR017C Recombinant
 YBR017C Antibody
 YBR0224 ELISA Kit
 YBR0224 Recombinant
 YBR0224 Antibody
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Importin subunit beta-3

 Importin subunit beta-3 ELISA Kit
 Importin subunit beta-3 Recombinant
 Importin subunit beta-3 Antibody
Also known as Importin subunit beta-3 (Importin beta sal3).
Involved in the nuclear import of cdc25 and mcs1.
 sal3 ELISA Kit
 sal3 Recombinant
 sal3 Antibody
 pse1 ELISA Kit
 pse1 Recombinant
 pse1 Antibody
 SPCC1840.03 ELISA Kit
 SPCC1840.03 Recombinant
 SPCC1840.03 Antibody
Table BarTOPTable Bar
 

Importin subunit beta-4

 Importin subunit beta-4 ELISA Kit
 Importin subunit beta-4 Recombinant
 Importin subunit beta-4 Antibody
Also known as Importin subunit beta-4 (Importin-123) (Karyopherin subunit beta-4) (Karyopherin-123) (Ran-binding protein YRB4).
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Its predominant cargo substrate seems to be ribosomal proteins (PubMed:9321403). Required for import of the ribbosomal assembly factor NMD3 (PubMed:12612077). May be involved in nuclear transport of YAP1 (PubMed:11274141). Mediates the nuclear import of histones H3 and H4 (PubMed:11694505). Mediates docking of the importi
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n/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11423015). At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of the cargo (PubMed:9321403). The importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11423015).
 KAP123 ELISA Kit
 KAP123 Recombinant
 KAP123 Antibody
 YRB4 ELISA Kit
 YRB4 Recombinant
 YRB4 Antibody
 YER110C ELISA Kit
 YER110C Recombinant
 YER110C Antibody
Table BarTOPTable Bar
 

Importin subunit beta-5

 Importin subunit beta-5 ELISA Kit
 Importin subunit beta-5 Recombinant
 Importin subunit beta-5 Antibody
Also known as Importin subunit beta-5 (114 kDa karyopherin) (Karyopherin subunit beta-5) (Karyopherin-114).
Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Serves a receptor for nuclear localization signals. Mediates the nuclear import of TATA-binding protein (TBP) and of histones H2A and H2B ().
 kap114 ELISA Kit
 kap114 Recombinant
 kap114 Antibody
 SPAC22H10.03c ELISA Kit
 SPAC22H10.03c Recombinant
 SPAC22H10.03c Antibody
Table BarTOPTable Bar
 

Importin-11

 Importin-11 ELISA Kit
 Importin-11 Recombinant
 Importin-11 Antibody
Also known as Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11).
IPO11: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated
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through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBE2E3, and of RPL12. Belongs to the importin beta family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Karyopherin; Nuclear import

Chromosomal Location of Human Ortholog: 5q12.1

Cellular Component: cytosol; nuclear envelope

Molecular Function: protein binding; protein transporter activity

Biological Process: transcription factor import into nucleus
 IPO11 ELISA Kit
 IPO11 Recombinant
 IPO11 Antibody
 RANBP11 ELISA Kit
 RANBP11 Recombinant
 RANBP11 Antibody
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Importin-13

 Importin-13 ELISA Kit
 Importin-13 Recombinant
 Importin-13 Antibody
Also known as Importin-13 (Imp13).
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, R
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an-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus ().
 IPO13 ELISA Kit
 IPO13 Recombinant
 IPO13 Antibody
 RCJMB04_27p9 ELISA Kit
 RCJMB04_27p9 Recombinant
 RCJMB04_27p9 Antibody
Table BarTOPTable Bar
 

Importin-13 homolog A

 Importin-13 homolog A ELISA Kit
 Importin-13 homolog A Recombinant
 Importin-13 homolog A Antibody
Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.
 ipo13A ELISA Kit
 ipo13A Recombinant
 ipo13A Antibody
 DDB_G0293110 ELISA Kit
 DDB_G0293110 Recombinant
 DDB_G0293110 Antibody
Table BarTOPTable Bar
 

Importin-13 homolog B

 Importin-13 homolog B ELISA Kit
 Importin-13 homolog B Recombinant
 Importin-13 homolog B Antibody
Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.
 ipo13B ELISA Kit
 ipo13B Recombinant
 ipo13B Antibody
 DDB_G0279441 ELISA Kit
 DDB_G0279441 Recombinant
 DDB_G0279441 Antibody
Table BarTOPTable Bar
 

Importin-4

 Importin-4 ELISA Kit
 Importin-4 Recombinant
 Importin-4 Antibody
Also known as Importin-4 (Imp4) (Importin-4a) (Imp4a) (Ran-binding protein 4) (RanBP4).
IPO4: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and impo
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rtin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Belongs to the importin beta family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Karyopherin; Nuclear import

Cellular Component: cytoplasm; membrane; nuclear chromatin; nuclear membrane; protein complex

Molecular Function: nuclear localization sequence binding; protein binding; protein transporter activity

Biological Process: DNA replication-dependent nucleosome assembly; DNA replication-independent nucleosome assembly; NLS-bearing substrate import into nucleus; protein import into nucleus, docking; protein import into nucleus, translocation; ribosomal protein import into nucleus; ribosome biogenesis and assembly
 Ipo4 ELISA Kit
 Ipo4 Recombinant
 Ipo4 Antibody
 Imp4a ELISA Kit
 Imp4a Recombinant
 Imp4a Antibody
 Ranbp4 ELISA Kit
 Ranbp4 Recombinant
 Ranbp4 Antibody
Table BarTOPTable Bar
 

Importin-5

 Importin-5 ELISA Kit
 Importin-5 Recombinant
 Importin-5 Antibody
Also known as Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5).
KPNB3: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate co
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mplex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Belongs to the importin beta family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Karyopherin; Nuclear import; Nucleolus

Cellular Component: cytoplasm; Golgi apparatus; intracellular membrane-bound organelle; membrane; nuclear membrane; nucleoplasm; nucleus

Molecular Function: nuclear localization sequence binding; protein binding; protein transporter activity

Biological Process: NLS-bearing substrate import into nucleus; positive regulation of protein import into nucleus; protein import into nucleus, docking; protein import into nucleus, translocation; ribosomal protein import into nucleus
 Ipo5 ELISA Kit
 Ipo5 Recombinant
 Ipo5 Antibody
 Kpnb3 ELISA Kit
 Kpnb3 Recombinant
 Kpnb3 Antibody
 Ranbp5 ELISA Kit
 Ranbp5 Recombinant
 Ranbp5 Antibody
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Importin-7

 Importin-7 ELISA Kit
 Importin-7 Recombinant
 Importin-7 Antibody
Also known as Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7).
IPO7: a beta importin protein. Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin beta-1 subunit. A receptor for nuclear localization signals (NLS) that promotes translocation of import substrates through the nuclear pore co
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mplex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.

Protein type: Karyopherin; Nuclear export; Nuclear import

Cellular Component: cytoplasm; cytosol; membrane; nuclear envelope; nucleoplasm

Molecular Function: histone binding; protein binding; protein transporter activity; SMAD binding

Biological Process: innate immune response; protein import into nucleus; signal transduction
 Ipo7 ELISA Kit
 Ipo7 Recombinant
 Ipo7 Antibody
 Ranbp7 ELISA Kit
 Ranbp7 Recombinant
 Ranbp7 Antibody
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Importin-8

 Importin-8 ELISA Kit
 Importin-8 Recombinant
 Importin-8 Antibody
Also known as Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8).
IPO8: Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter- like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import
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substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19. Belongs to the importin beta family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein regulator, misc.; Karyopherin; Nuclear export; Nuclear import

Cellular Component: cytosol; integral to plasma membrane; nuclear envelope

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; protein transporter activity

Biological Process: protein import into nucleus; signal transduction; transmembrane transport; transport
 Ipo8 ELISA Kit
 Ipo8 Recombinant
 Ipo8 Antibody
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Importin-9

 Importin-9 ELISA Kit
 Importin-9 Recombinant
 Importin-9 Antibody
Also known as Importin-9 (Imp9) (Importin-9a) (Imp9a) (Importin-9b) (Imp9b) (Ran-binding protein 9) (RanBP9).
IPO9: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate comple
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x dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of H2B histone, RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones, RPL4 and RPL6. Belongs to the importin beta family.

Protein type: Karyopherin; Nuclear import

Cellular Component: cytoplasm; cytosol; membrane; nuclear envelope

Molecular Function: histone binding; protein transporter activity; Ran GTPase binding

Biological Process: protein import into nucleus; protein stabilization; ribosomal protein import into nucleus; ribosome biogenesis and assembly; transcription factor import into nucleus
 Ipo9 ELISA Kit
 Ipo9 Recombinant
 Ipo9 Antibody
 Imp9 ELISA Kit
 Imp9 Recombinant
 Imp9 Antibody
 Ranbp9 ELISA Kit
 Ranbp9 Recombinant
 Ranbp9 Antibody
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Proteins Root Name Listing
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