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Inactive heparanase

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Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro) (By similarity).

Below are the list of possible Inactive heparanase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Inactive heparanase-2

 Inactive heparanase-2 ELISA Kit
 Inactive heparanase-2 Recombinant
 Inactive heparanase-2 Antibody
Also known as Inactive heparanase-2 (Hpa2).
HPSE2: Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro). Defects in HPSE2 are the cause of urofacial syndrome (UFS). A rare autosomal recessive characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void comp
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letely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure. Belongs to the glycosyl hydrolase 79 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.2.-.-; Glycan Metabolism - glycosaminoglycan degradation; Hydrolase

Cellular Component: intracellular; proteinaceous extracellular matrix

Molecular Function: heparan sulfate proteoglycan binding

Biological Process: extracellular matrix organization and biogenesis; positive regulation of cell proliferation
 Hpse2 ELISA Kit
 Hpse2 Recombinant
 Hpse2 Antibody
 Hpa2 ELISA Kit
 Hpa2 Recombinant
 Hpa2 Antibody
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