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Inactive peptidyl-prolyl cis-trans isomerase

Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).

Below are the list of possible Inactive peptidyl-prolyl cis-trans isomerase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Inactive peptidyl-prolyl cis-trans isomerase FKBP6

 Inactive peptidyl-prolyl cis-trans isomerase FKBP6 ELISA Kit
 Inactive peptidyl-prolyl cis-trans isomerase FKBP6 Recombinant
 Inactive peptidyl-prolyl cis-trans isomerase FKBP6 Antibody
Also known as Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (Inactive PPIase FKBP6) (36 kDa FK506-binding protein) (36 kDa FKBP) (FKBP-36) (FK506-binding protein 6) (FKBP-6) (Immunophilin FKBP36).
FKBP6: PPIases accelerate the folding of proteins. FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q
11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC; Isomerase

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum membrane; synaptonemal complex

Molecular Function: Hsp90 protein binding; identical protein binding; peptidyl-prolyl cis-trans isomerase activity; protein binding

Biological Process: DNA methylation during gametogenesis; meiosis; positive regulation of viral genome replication; protein folding; RNA-mediated gene silencing; spermatogenesis
 FKBP6 Recombinant
 FKBP6 Antibody
 FKBP36 Recombinant
 FKBP36 Antibody
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