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Inhibitor of growth protein

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Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.

Below are the list of possible Inhibitor of growth protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Inhibitor of growth protein 1

 Inhibitor of growth protein 1 ELISA Kit
 Inhibitor of growth protein 1 Recombinant
 Inhibitor of growth protein 1 Antibody
ING1: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene. Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC); also known as squamous cell carcinoma of the head and neck. Belongs to the ING family. 5 isoforms of the human protein are produced by alternativ
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e splicing.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: cytoplasm; nucleoplasm

Molecular Function: methylated histone residue binding; protein binding

Disease: Squamous Cell Carcinoma, Head And Neck
 ING1 ELISA Kit
 ING1 Recombinant
 ING1 Antibody
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Inhibitor of growth protein 2

 Inhibitor of growth protein 2 ELISA Kit
 Inhibitor of growth protein 2 Recombinant
 Inhibitor of growth protein 2 Antibody
Also known as Inhibitor of growth protein 2 (Inhibitor of growth 1-like protein) (ING1Lp) (p32) (p33ING2).
ING2: Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulat
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ed by binding to phosphoinositides (PtdInsPs). Belongs to the ING family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 4q35.1

Cellular Component: CCAAT-binding factor complex; cytoplasm; Golgi apparatus; nucleoplasm; nucleus; plasma membrane; Sin3 complex

Molecular Function: DNA binding; methylated histone residue binding; phosphoinositide binding; protein binding; protein complex binding

Biological Process: male germ-line stem cell division; male meiosis I; positive regulation of histone deacetylation; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of transcription, DNA-dependent; signal transduction; sperm motility; spermatid development; spermatogenesis
 ING2 ELISA Kit
 ING2 Recombinant
 ING2 Antibody
 ING1L ELISA Kit
 ING1L Recombinant
 ING1L Antibody
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Inhibitor of growth protein 3

 Inhibitor of growth protein 3 ELISA Kit
 Inhibitor of growth protein 3 Recombinant
 Inhibitor of growth protein 3 Antibody
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the a
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ctivation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome ().
 ING3 ELISA Kit
 ING3 Recombinant
 ING3 Antibody
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Inhibitor of growth protein 4

 Inhibitor of growth protein 4 ELISA Kit
 Inhibitor of growth protein 4 Recombinant
 Inhibitor of growth protein 4 Antibody
Also known as Inhibitor of growth protein 4 (p29ING4).
Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation ().
 ING4 ELISA Kit
 ING4 Recombinant
 ING4 Antibody
 RCJMB04_8l5 ELISA Kit
 RCJMB04_8l5 Recombinant
 RCJMB04_8l5 Antibody
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Inhibitor of growth protein 5

 Inhibitor of growth protein 5 ELISA Kit
 Inhibitor of growth protein 5 Recombinant
 Inhibitor of growth protein 5 Antibody
ING5: Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. B
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elongs to the ING family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor

Cellular Component: nucleus

Molecular Function: chromatin binding; methylated histone residue binding

Biological Process: DNA replication; negative regulation of cell proliferation; negative regulation of growth; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; protein amino acid acetylation
 Ing5 ELISA Kit
 Ing5 Recombinant
 Ing5 Antibody
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