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Insulin-like growth factor

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The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.

Below are the list of possible Insulin-like growth factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Insulin-like growth factor

 Insulin-like growth factor ELISA Kit
 Insulin-like growth factor Recombinant
 Insulin-like growth factor Antibody
Also known as Insulin-like growth factor (IGF).
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting a
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ctivity.
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Insulin-like growth factor I

 Insulin-like growth factor I ELISA Kit
 Insulin-like growth factor I Recombinant
 Insulin-like growth factor I Antibody
Also known as Insulin-like growth factor I (IGF-I) (Mechano growth factor) (MGF) (Somatomedin-C).
IGF1: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose
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transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency). IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. Belongs to the insulin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: extracellular region; extracellular space; insulin-like growth factor binding protein complex; plasma membrane

Molecular Function: hormone activity; insulin receptor binding; insulin-like growth factor receptor binding; integrin binding; protein binding

Biological Process: activation of MAPK activity; activation of protein kinase B; cell activation; cell motility; cell proliferation; cellular protein metabolic process; DNA replication; glycolate metabolic process; insulin-like growth factor receptor signaling pathway; muscle development; muscle hypertrophy; myoblast differentiation; myoblast proliferation; myotube cell development; negative regulation of apoptosis; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; platelet degranulation; positive regulation of activated T cell proliferation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA binding; positive regulation of DNA replication; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of glycolysis; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of MAPKKK cascade; positive regulation of mitosis; positive regulation of osteoblast differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein import into nucleus, translocation; positive regulation of protein secretion; positive regulation of Ras protein signal transduction; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat5 protein; protein kinase B signaling cascade; protein stabilization; proteoglycan biosynthetic process; Ras protein signal transduction; regulation of gene expression; regulation of multicellular organism growth; response to heat; satellite cell compartment self-renewal involved in skeletal muscle regeneration; signal transduction; skeletal development

Disease: Insulin-like Growth Factor I Deficiency
 IGF1 ELISA Kit
 IGF1 Recombinant
 IGF1 Antibody
 IBP1 ELISA Kit
 IBP1 Recombinant
 IBP1 Antibody
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Insulin-like growth factor I, adult form

 Insulin-like growth factor I, adult form ELISA Kit
 Insulin-like growth factor I, adult form Recombinant
 Insulin-like growth factor I, adult form Antibody
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the a
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lpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling.
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Insulin-like growth factor I, juvenile form

 Insulin-like growth factor I, juvenile form ELISA Kit
 Insulin-like growth factor I, juvenile form Recombinant
 Insulin-like growth factor I, juvenile form Antibody
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the a
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lpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling.
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Insulin-like growth factor I-A

 Insulin-like growth factor I-A ELISA Kit
 Insulin-like growth factor I-A Recombinant
 Insulin-like growth factor I-A Antibody
Also known as Insulin-like growth factor I-A (IGF-I') (IGF-IA) (xIGF-1) (Somatomedin).
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes head development by inhibiting Wnt signaling during embryogenesis (PubMed:11709186, PubMed:11944947). Acts as a ligand for IGF1R. Binds to the
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alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling ().
 igf1-a ELISA Kit
 igf1-a Recombinant
 igf1-a Antibody
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Insulin-like growth factor I-B

 Insulin-like growth factor I-B ELISA Kit
 Insulin-like growth factor I-B Recombinant
 Insulin-like growth factor I-B Antibody
Also known as Insulin-like growth factor I-B (IGF-I'') (IGF-IB) (Somatomedin).
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates ty
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rosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling.
 igf1-b ELISA Kit
 igf1-b Recombinant
 igf1-b Antibody
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Insulin-like growth factor II

 Insulin-like growth factor II ELISA Kit
 Insulin-like growth factor II Recombinant
 Insulin-like growth factor II Antibody
Also known as Insulin-like growth factor II (IGF-II).
The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion.
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Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3 ().
 IGF2 ELISA Kit
 IGF2 Recombinant
 IGF2 Antibody
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Insulin-like growth factor II-A

 Insulin-like growth factor II-A ELISA Kit
 Insulin-like growth factor II-A Recombinant
 Insulin-like growth factor II-A Antibody
Also known as Insulin-like growth factor II-A (IGF-II-A) (Insulin-like growth factor 2-A) (xIGF-2).
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes anterior neural development.
 igf2-a ELISA Kit
 igf2-a Recombinant
 igf2-a Antibody
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Insulin-like growth factor II-B

 Insulin-like growth factor II-B ELISA Kit
 Insulin-like growth factor II-B Recombinant
 Insulin-like growth factor II-B Antibody
Also known as Insulin-like growth factor II-B (IGF-II-B) (Insulin-like growth factor 2-B).
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes anterior neural development ().
 igf2-b ELISA Kit
 igf2-b Recombinant
 igf2-b Antibody
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Insulin-like growth factor III

 Insulin-like growth factor III ELISA Kit
 Insulin-like growth factor III Recombinant
 Insulin-like growth factor III Antibody
Also known as Insulin-like growth factor III (IGF-III) (Insulin-like growth factor 3) (xIGF-3).
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes anterior neural development.
 igf3 ELISA Kit
 igf3 Recombinant
 igf3 Antibody
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