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Insulin-like growth factor 2 mRNA-binding protein

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RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of beta-actin/ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells (By similarity). Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localization (By similarity). Binds to and stabilizes BTRC/FBW1A mRNA (By similarity). Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2 (By similarity). During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Interacts with GAP43 transcript and transports it to axons. Regulates localized ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons.

Below are the list of possible Insulin-like growth factor 2 mRNA-binding protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Insulin-like growth factor 2 mRNA-binding protein 1

 Insulin-like growth factor 2 mRNA-binding protein 1 ELISA Kit
 Insulin-like growth factor 2 mRNA-binding protein 1 Recombinant
 Insulin-like growth factor 2 mRNA-binding protein 1 Antibody
Also known as Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (B-actin zipcode-binding protein 1) (ZBP1) (rZBP-1) (IGF-II mRNA-binding protein 1) (VICKZ family member 1).
IGF2BP1: a conserved trans-acting factor that can control translation of specific mRNAs in vivo. Contains four K homology (KH) domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the target mRNAs and repressing translation. Target mRNAs include those encoding beta-actin and insulin-like growth factor 2 (IGF2). Tyrosine phosphorylation apparently abolish
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es translational repression of actin expression by decreasing its binding beta-actin mRNA. May have a role in progression of ovarian cancer. Contains nuclear export signals within the RNA-binding KH2 and KH4 domains. Aberrant expression may interfere with c-myc regulation.

Protein type: RNA-binding; Translation

Cellular Component: cytoplasm; dendrite; ribonucleoprotein complex; stress granule

Molecular Function: mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA binding; translation regulator activity

Biological Process: negative regulation of translation; pallium cell proliferation in the forebrain; RNA localization
 Igf2bp1 ELISA Kit
 Igf2bp1 Recombinant
 Igf2bp1 Antibody
 Imp1 ELISA Kit
 Imp1 Recombinant
 Imp1 Antibody
 Vickz1 ELISA Kit
 Vickz1 Recombinant
 Vickz1 Antibody
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Insulin-like growth factor 2 mRNA-binding protein 2

 Insulin-like growth factor 2 mRNA-binding protein 2 ELISA Kit
 Insulin-like growth factor 2 mRNA-binding protein 2 Recombinant
 Insulin-like growth factor 2 mRNA-binding protein 2 Antibody
Also known as Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2).
This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSe
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q, Sep 2016]
 IGF2BP2 ELISA Kit
 IGF2BP2 Recombinant
 IGF2BP2 Antibody
 IMP2 ELISA Kit
 IMP2 Recombinant
 IMP2 Antibody
 VICKZ2 ELISA Kit
 VICKZ2 Recombinant
 VICKZ2 Antibody
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Insulin-like growth factor 2 mRNA-binding protein 3

 Insulin-like growth factor 2 mRNA-binding protein 3 ELISA Kit
 Insulin-like growth factor 2 mRNA-binding protein 3 Recombinant
 Insulin-like growth factor 2 mRNA-binding protein 3 Antibody
Also known as Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (Decapentaplegic and Vg-related 1 RNA-binding protein) (IGF-II mRNA-binding protein 3) (VICKZ family member 3) (Vg1 RNA-binding protein) (Vg1-RBP).
RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-m
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ediated degradation (). Involved in the neuronal crest migration.
 igf2bp3 ELISA Kit
 igf2bp3 Recombinant
 igf2bp3 Antibody
 dvr1rbp ELISA Kit
 dvr1rbp Recombinant
 dvr1rbp Antibody
 vickz3 ELISA Kit
 vickz3 Recombinant
 vickz3 Antibody
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Insulin-like growth factor 2 mRNA-binding protein 3-A

 Insulin-like growth factor 2 mRNA-binding protein 3-A ELISA Kit
 Insulin-like growth factor 2 mRNA-binding protein 3-A Recombinant
 Insulin-like growth factor 2 mRNA-binding protein 3-A Antibody
Also known as Insulin-like growth factor 2 mRNA-binding protein 3-A (IGF2 mRNA-binding protein 3-A) (IMP-3-A) (69 kDa RNA-binding protein A) (IGF-II mRNA-binding protein 3-A) (KH domain-containing transcription factor B3-A) (RNA-binding protein Vera-A) (Trans-acting factor B3-A) (VICKZ family member 3-A) (VLE-binding protein A) (Vg1 RNA-binding protein A) (Vg1 RBP-A) (Vg1 localization element binding protein A) (VgLE-binding and ER association protein A).
RNA-binding protein that act as a regulator of mRNA transport and localization. Mediates the specific association of Vg1 RNA to microtubu
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les. Binds specifically to the vegetal localization elements (VLE or VgLE) in the 3'-UTR of Vg1 and VegT mRNAs. Binds to the Vg1 and VegT mRNAs in both the nucleus and the cytoplasm. Binds to the RNA sequence motif 5'-UUCAC-3'. May regulate mRNA translation (). Acts as a transcription regulator (). Binds to the 5'-[TA]GGTTACT-3' motif within element 3 of the TFIIIA gene promoter. Binds DNA ().
 igf2bp3-a ELISA Kit
 igf2bp3-a Recombinant
 igf2bp3-a Antibody
 vera-a ELISA Kit
 vera-a Recombinant
 vera-a Antibody
 vickz3-a ELISA Kit
 vickz3-a Recombinant
 vickz3-a Antibody
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Insulin-like growth factor 2 mRNA-binding protein 3-B

 Insulin-like growth factor 2 mRNA-binding protein 3-B ELISA Kit
 Insulin-like growth factor 2 mRNA-binding protein 3-B Recombinant
 Insulin-like growth factor 2 mRNA-binding protein 3-B Antibody
Also known as Insulin-like growth factor 2 mRNA-binding protein 3-B (IGF2 mRNA-binding protein 3-B) (IMP-3-B) (69 kDa RNA-binding protein B) (B3.65 protein B) (IGF-II mRNA-binding protein 3-B) (KH domain-containing transcription factor B3-B) (RNA-binding protein Vera-B) (Trans-acting factor B3-B) (VICKZ family member 3-B) (VLE-binding protein B) (Vg1 RNA-binding protein B) (Vg1 RBP-B) (Vg1 localiz
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ation element binding protein B) (VgLE-binding and ER association protein B).
RNA-binding protein that acts as a regulator of mRNA transport and localization. Mediates the specific association of Vg1 RNA to microtubules. May regulate mRNA translation (). Binds specifically to the vegetal localization elements (VLE or VgLE) in the 3'-UTR of Vg1 and VegT mRNAs. Binds to the Vg1 and VegT mRNAs in both the nucleus and the cytoplasm. Binds to the RNA sequence motif 5'-UUCAC-3'. May regulate mRNA translation (). Acts as a transcription regulator. Binds to the 5'-[TA]GGTTACT-3' motif within element 3 of the TFIIIA gene promoter. Binds DNA.
 igf2bp3-b ELISA Kit
 igf2bp3-b Recombinant
 igf2bp3-b Antibody
 vickz3-b ELISA Kit
 vickz3-b Recombinant
 vickz3-b Antibody
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