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Insulin receptor substrate

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Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation.

Below are the list of possible Insulin receptor substrate products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Insulin receptor substrate 1

 Insulin receptor substrate 1 ELISA Kit
 Insulin receptor substrate 1 Recombinant
 Insulin receptor substrate 1 Antibody
Also known as Insulin receptor substrate 1 (dIRS) (Protein chico).
Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (). May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insu
>>>
lin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation.
 chico ELISA Kit
 chico Recombinant
 chico Antibody
 IRS ELISA Kit
 IRS Recombinant
 IRS Antibody
 CG5686 ELISA Kit
 CG5686 Recombinant
 CG5686 Antibody
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Insulin receptor substrate 1-A

 Insulin receptor substrate 1-A ELISA Kit
 Insulin receptor substrate 1-A Recombinant
 Insulin receptor substrate 1-A Antibody
Also known as Insulin receptor substrate 1-A (IRS1-A) (xIRS-1-A) (XIRS-L).
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or grb2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (
>>>
).
 irs1-a ELISA Kit
 irs1-a Recombinant
 irs1-a Antibody
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Insulin receptor substrate 1-B

 Insulin receptor substrate 1-B ELISA Kit
 Insulin receptor substrate 1-B Recombinant
 Insulin receptor substrate 1-B Antibody
Also known as Insulin receptor substrate 1-B (IRS1-B) (xIRS-1-B) (XIRS-L').
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or grb2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit
>>>
().
 irs1-b ELISA Kit
 irs1-b Recombinant
 irs1-b Antibody
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Insulin receptor substrate 2

 Insulin receptor substrate 2 ELISA Kit
 Insulin receptor substrate 2 Recombinant
 Insulin receptor substrate 2 Antibody
Also known as Insulin receptor substrate 2 (IRS-2).
IRS2: May mediate the control of various cellular processes by insulin. Interacts with PHIP.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: cytosol; plasma membrane

Molecular Function: 1-phosphatidylinositol-3-kinase activity; insulin re
>>>
ceptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphoinositide 3-kinase binding; protein binding; Ras guanyl-nucleotide exchange factor activity

Biological Process: cellular response to insulin stimulus; glucose metabolic process; insulin receptor signaling pathway; lipid homeostasis; MAPKKK cascade; negative regulation of B cell apoptosis; negative regulation of kinase activity; phosphoinositide-mediated signaling; positive regulation of B cell proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of insulin secretion; regulation of lipid metabolic process; regulation of phosphoinositide 3-kinase cascade; response to glucose stimulus; signal transduction

Disease: Diabetes Mellitus, Noninsulin-dependent
 IRS2 ELISA Kit
 IRS2 Recombinant
 IRS2 Antibody
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Insulin receptor substrate 2-A

 Insulin receptor substrate 2-A ELISA Kit
 Insulin receptor substrate 2-A Recombinant
 Insulin receptor substrate 2-A Antibody
Also known as Insulin receptor substrate 2-A (IRS-2-A) (Insulin receptor substrate-undetermined designation) (Insulin receptor substrate-unique) (xIRS-u).
Potentiates insulin signaling.
 irs2-a ELISA Kit
 irs2-a Recombinant
 irs2-a Antibody
 irsu ELISA Kit
 irsu Recombinant
 irsu Antibody
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Insulin receptor substrate 2-B

 Insulin receptor substrate 2-B ELISA Kit
 Insulin receptor substrate 2-B Recombinant
 Insulin receptor substrate 2-B Antibody
Also known as Insulin receptor substrate 2-B (IRS-2-B).
Potentiates insulin signaling.
 irs2-b ELISA Kit
 irs2-b Recombinant
 irs2-b Antibody
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Insulin receptor substrate 4

 Insulin receptor substrate 4 ELISA Kit
 Insulin receptor substrate 4 Recombinant
 Insulin receptor substrate 4 Antibody
Also known as Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160).
IRS4: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic sign
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aling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGFI signaling pathway by suppressing the function of IRS1 and IRS2.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: Xq22.3

Cellular Component: cytosol; plasma membrane

Molecular Function: insulin receptor binding; phosphoinositide 3-kinase binding; protein binding; SH3/SH2 adaptor activity

Biological Process: insulin receptor signaling pathway; regulation of lipid metabolic process; signal transduction
 IRS4 ELISA Kit
 IRS4 Recombinant
 IRS4 Antibody
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