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Integrin-linked protein kinase

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Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

Below are the list of possible Integrin-linked protein kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Integrin-linked protein kinase

 Integrin-linked protein kinase ELISA Kit
 Integrin-linked protein kinase Recombinant
 Integrin-linked protein kinase Antibody
ILK: a tyrosine kinase-like kinase of the MLK family. Couples integrins and growth factors to downstream pathways involved in cell survival, cell cycle control, cell-cell adhesion and cell motility. Functions as a scaffold bridging the extra-cellular matrix and growth factor receptors to the actin cytoskeleton through interactions with the ILK-PINCH complex. This complex, which includes integrin,
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PINCH (which links ILK to receptor tyrosine kinases via Nck2), PARVA and affixin, is considered to be one of the convergence points of integrin- and growth factor-signaling pathways. May be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Stimulated downstream of PI3 kinase. Increased expression is correlated with progression of several tumor types, including breast, prostate, and colon carcinomas. Overexpression drives anchorage-independent growth and faster cell cycle.

Protein type: EC 2.7.11.1; ILK subfamily; Kinase, protein; MLK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group

Cellular Component: axon; cell junction; cell soma; costamere; cytoplasm; dendritic shaft; focal adhesion; intercellular junction; lamellipodium; membrane; nucleoplasm; protein complex; stress fiber; terminal button

Molecular Function: integrin binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; SH3 domain binding; signal transducer activity

Biological Process: cell aging; cell cycle arrest; cell projection organization and biogenesis; establishment and/or maintenance of epithelial cell polarity; fibril organization and biogenesis; integrin-mediated signaling pathway; myelin formation; myelination in the peripheral nervous system; negative regulation of apoptosis; negative regulation of neuron apoptosis; negative regulation of protein kinase activity; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; nerve development; neurite morphogenesis; peptidyl-serine phosphorylation; positive regulation of axon extension; positive regulation of axonogenesis; positive regulation of BMP signaling pathway; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of dendrite morphogenesis; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of myoblast differentiation; positive regulation of osteoblast differentiation; positive regulation of phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; protein heterooligomerization; protein kinase B signaling cascade; regulation of actin cytoskeleton organization and biogenesis; regulation of cell growth; Schwann cell development; ureteric bud branching
 Ilk ELISA Kit
 Ilk Recombinant
 Ilk Antibody
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Integrin-linked protein kinase homolog pat-4

 Integrin-linked protein kinase homolog pat-4 ELISA Kit
 Integrin-linked protein kinase homolog pat-4 Recombinant
 Integrin-linked protein kinase homolog pat-4 Antibody
Also known as Integrin-linked protein kinase homolog pat-4 (ILK homolog) (Paralyzed and arrested elongation at two-fold protein 4).
Probable pseudokinase that acts as an adapter protein. Involved in the assembly of dense bodies and M lines during body wall muscle development by recruiting several of their components to integrin-mediated attachment sites (PubMed:12015115). Plays a role in distal
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tip cell (DTC) migration and in oocyte development probably by regulating the actin cytoskeleton (PubMed:16476426). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles (PubMed:16495308). May be involved in thermotolerance and lifespan (PubMed:24314125).
 pat-4 ELISA Kit
 pat-4 Recombinant
 pat-4 Antibody
 C29F9.7 ELISA Kit
 C29F9.7 Recombinant
 C29F9.7 Antibody
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