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Interferon-induced, double-stranded RNA-activated protein kinase

IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. Also phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteosomal degradation. Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs. Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6. Can act as both a positive and negative regulator of the insulin signaling pathway (ISP). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes. Can trigger apoptosis via FADD-mediated activation of CASP8. Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin.

Below are the list of possible Interferon-induced, double-stranded RNA-activated protein kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Interferon-induced, double-stranded RNA-activated protein kinase

 Interferon-induced, double-stranded RNA-activated protein kinase ELISA Kit
 Interferon-induced, double-stranded RNA-activated protein kinase Recombinant
 Interferon-induced, double-stranded RNA-activated protein kinase Antibody
Also known as Interferon-induced, double-stranded RNA-activated protein kinase (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein ki.
PKR: a protein kinase of the PEK family. Upon binding double-stranded RNA, it becomes autophosphorylated and activated. Phosphorylates and inhibits the alpha subunit of eIF2 alpha, which leads to an inhibition of the initiation of protein synthesis. Controls the activation of several transcription factors such as NF-kappaB, p53 and Stats.
Mediates apoptosis induced by many different stimuli, such as LPS, TNF-alpha, viral infection and serum starvation.

Protein type: EC; EC; Kinase, protein; Other group; PEK family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation

Chromosomal Location of Human Ortholog: 2p22-p21

Cellular Component: cytoplasm; cytosol; membrane; perinuclear region of cytoplasm; ribosome

Molecular Function: double-stranded RNA binding; eukaryotic translation initiation factor 2alpha kinase activity; protein binding; protein kinase activity; protein phosphatase regulator activity; protein serine/threonine kinase activity

Biological Process: activation of MAPKK activity; activation of NF-kappaB transcription factor; cellular response to amino acid starvation; evasion by virus of host immune response; negative regulation of cell proliferation; negative regulation of osteoblast proliferation; negative regulation of translation; negative regulation of viral genome replication; positive regulation of chemokine production; positive regulation of cytokine production; positive regulation of stress-activated MAPK cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation; response to virus
 EIF2AK2 Recombinant
 EIF2AK2 Antibody
 PKR Recombinant
 PKR Antibody
 PRKR Recombinant
 PRKR Antibody
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