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Interferon-inducible double-stranded RNA-dependent protein kinase activator

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Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).

Below are the list of possible Interferon-inducible double-stranded RNA-dependent protein kinase activator products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Interferon-inducible double-stranded RNA-dependent protein kinase activator A

 Interferon-inducible double-stranded RNA-dependent protein kinase activator A ELISA Kit
 Interferon-inducible double-stranded RNA-dependent protein kinase activator A Recombinant
 Interferon-inducible double-stranded RNA-dependent protein kinase activator A Antibody
Also known as Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (Protein activator of the interferon-induced protein kinase) (Protein kinase, interferon-inducible double-stranded RNA-dependent activator).
PACT: a double strand RNA binding protein (dsRBP). Interacts with TRBP and Dicer to stimulate the cleavage of double-stranded or short hairpin RNA to siRNA. Appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor. Activates the interferon-induced protein kinase PKR. T
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hree alternatively spliced human isoforms have been reported.

Protein type: Activator; RNA processing; RNA-binding

Chromosomal Location of Human Ortholog: 2q31.2

Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm

Molecular Function: double-stranded RNA binding; enzyme binding; identical protein binding; protein binding; protein homodimerization activity

Biological Process: immune response; miRNA-mediated gene silencing, production of miRNAs; negative regulation of cell proliferation; pre-microRNA processing; response to virus; RNA interference, production of siRNA; RNA-mediated gene silencing

Disease: Dystonia 16
 PRKRA ELISA Kit
 PRKRA Recombinant
 PRKRA Antibody
 PACT ELISA Kit
 PACT Recombinant
 PACT Antibody
 RAX ELISA Kit
 RAX Recombinant
 RAX Antibody
 HSD-14 ELISA Kit
 HSD-14 Recombinant
 HSD-14 Antibody
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Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog

 Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog ELISA Kit
 Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog Recombinant
 Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog Antibody
Activates eif2ak2/pkr in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of eif2s1/efi2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by dicer1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by dicer1 ().
 prkra ELISA Kit
 prkra Recombinant
 prkra Antibody
 si:ch73-57b20.1 ELISA Kit
 si:ch73-57b20.1 Recombinant
 si:ch73-57b20.1 Antibody
 zgc:162619 ELISA Kit
 zgc:162619 Recombinant
 zgc:162619 Antibody
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Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog A

 Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog A ELISA Kit
 Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog A Recombinant
 Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog A Antibody
Activates eif2ak2/pkr in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of eif2s1/efi2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by dicer1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by dicer1 ().
 prkra-a ELISA Kit
 prkra-a Recombinant
 prkra-a Antibody
 prkra ELISA Kit
 prkra Recombinant
 prkra Antibody
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Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog B

 Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog B ELISA Kit
 Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog B Recombinant
 Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog B Antibody
Also known as Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog B (Double-stranded RNA-binding protein A) (XlRBPA).
Activates eif2ak2/pkr in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of eif2s1/efi2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by dicer1 and for subsequent siRNA-media
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ted post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by dicer1 ().
 prkra-b ELISA Kit
 prkra-b Recombinant
 prkra-b Antibody
 rbpa ELISA Kit
 rbpa Recombinant
 rbpa Antibody
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