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Interferon regulatory factor

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Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity).

Below are the list of possible Interferon regulatory factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Interferon regulatory factor 1

 Interferon regulatory factor 1 ELISA Kit
 Interferon regulatory factor 1 Recombinant
 Interferon regulatory factor 1 Antibody
Also known as Interferon regulatory factor 1 (IRF-1).
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor ().
 IRF1 ELISA Kit
 IRF1 Recombinant
 IRF1 Antibody
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Interferon regulatory factor 2

 Interferon regulatory factor 2 ELISA Kit
 Interferon regulatory factor 2 Recombinant
 Interferon regulatory factor 2 Antibody
Also known as Interferon regulatory factor 2 (IRF-2).
IRF2: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation throug
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h binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction acetylates IRF2 and regulates IRF2-dependent H4 promoter activity. By viruses and IFN. Expressed throughout the epithelium of the colon. Also expressed in lamina propria. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 4q34.1-q35.1

Cellular Component: cytoplasm; cytosol; focal adhesion; nucleoplasm

Molecular Function: DNA binding; protein binding; transcription factor activity

Biological Process: blood coagulation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent
 IRF2 ELISA Kit
 IRF2 Recombinant
 IRF2 Antibody
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Interferon regulatory factor 3

 Interferon regulatory factor 3 ELISA Kit
 Interferon regulatory factor 3 Recombinant
 Interferon regulatory factor 3 Antibody
Also known as Interferon regulatory factor 3 (IRF-3).
IRF3: interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as
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other interferon-induced genes.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 19q13.3-q13.4

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; transcription cofactor activity

Biological Process: apoptosis; defense response to virus; negative regulation of interferon type I production; positive regulation of interferon type I production; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; response to DNA damage stimulus; transcription from RNA polymerase II promoter

Disease: Herpes Simplex Encephalitis, Susceptibility To, 7
 IRF3 ELISA Kit
 IRF3 Recombinant
 IRF3 Antibody
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Interferon regulatory factor 4

 Interferon regulatory factor 4 ELISA Kit
 Interferon regulatory factor 4 Recombinant
 Interferon regulatory factor 4 Antibody
Also known as Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (Multiple myeloma oncogene 1) (NF-EM5).
IRF4: Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal tra
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nsduction mechanisms specific to lymphoid cells. Interacts with SPIB and DEF6. Not induced by interferons. Lymphoid cells. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 6p25-p23

Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; nucleus

Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity

Biological Process: defense response to protozoan; positive regulation of interleukin-10 biosynthetic process; positive regulation of interleukin-13 biosynthetic process; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-4 biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent

Disease: Skin/hair/eye Pigmentation, Variation In, 8
 IRF4 ELISA Kit
 IRF4 Recombinant
 IRF4 Antibody
 MUM1 ELISA Kit
 MUM1 Recombinant
 MUM1 Antibody
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Interferon regulatory factor 5

 Interferon regulatory factor 5 ELISA Kit
 Interferon regulatory factor 5 Recombinant
 Interferon regulatory factor 5 Antibody
Also known as Interferon regulatory factor 5 (IRF-5).
IRF5: Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. Homodimer, when phosphorylated. Belongs to the IRF family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcriptio
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n factor

Chromosomal Location of Human Ortholog: 7q32

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding

Biological Process: positive regulation of apoptosis; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of interleukin-12 production; positive regulation of transcription from RNA polymerase II promoter; response to muramyl dipeptide; response to peptidoglycan

Disease: Inflammatory Bowel Disease 14; Systemic Lupus Erythematosus, Susceptibility To, 10
 IRF5 ELISA Kit
 IRF5 Recombinant
 IRF5 Antibody
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Interferon regulatory factor 6

 Interferon regulatory factor 6 ELISA Kit
 Interferon regulatory factor 6 Recombinant
 Interferon regulatory factor 6 Antibody
Also known as Interferon regulatory factor 6 (IRF-6).
Probable DNA-binding transcriptional activator. It is a key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation (). May regulate WDR65 transcription ().
 IRF6 ELISA Kit
 IRF6 Recombinant
 IRF6 Antibody
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Interferon regulatory factor 7

 Interferon regulatory factor 7 ELISA Kit
 Interferon regulatory factor 7 Recombinant
 Interferon regulatory factor 7 Antibody
Also known as Interferon regulatory factor 7 (IRF-7).
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IR
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F7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]
 IRF7 ELISA Kit
 IRF7 Recombinant
 IRF7 Antibody
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Interferon regulatory factor 8

 Interferon regulatory factor 8 ELISA Kit
 Interferon regulatory factor 8 Recombinant
 Interferon regulatory factor 8 Antibody
Also known as Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (H-ICSBP) (ICSBP).
IRF8: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Interacts (via C-terminus) with TRIM21 (via C-terminus). Inte
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racts with COPS2. By IFNG/IFN-gamma. Predominantly expressed in lymphoid tissues. Belongs to the IRF family.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: protein binding; RNA polymerase II transcription factor activity, enhancer binding

Biological Process: immune response; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter

Disease: Immunodeficiency 32a; Monocyte And Dendritic Cell Deficiency, Autosomal Recessive
 IRF8 ELISA Kit
 IRF8 Recombinant
 IRF8 Antibody
 ICSBP1 ELISA Kit
 ICSBP1 Recombinant
 ICSBP1 Antibody
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Interferon regulatory factor 9

 Interferon regulatory factor 9 ELISA Kit
 Interferon regulatory factor 9 Recombinant
 Interferon regulatory factor 9 Antibody
Also known as Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma).
IRF9: Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak k
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inases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. Belongs to the IRF family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: cell surface receptor linked signal transduction; transcription from RNA polymerase II promoter
 IRF9 ELISA Kit
 IRF9 Recombinant
 IRF9 Antibody
 ISGF3G ELISA Kit
 ISGF3G Recombinant
 ISGF3G Antibody
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