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Interleukin

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Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Below are the list of possible Interleukin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Interleukin-1 alpha

 Interleukin-1 alpha ELISA Kit
 Interleukin-1 alpha Recombinant
 Interleukin-1 alpha Antibody
Also known as Interleukin-1 alpha (IL-1 alpha).
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase
>>>
from synovial cells.
 IL1A ELISA Kit
 IL1A Recombinant
 IL1A Antibody
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Interleukin-1 beta

 Interleukin-1 beta ELISA Kit
 Interleukin-1 beta Recombinant
 Interleukin-1 beta Antibody
Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.
 il1b ELISA Kit
 il1b Recombinant
 il1b Antibody
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Interleukin-10

 Interleukin-10 ELISA Kit
 Interleukin-10 Recombinant
 Interleukin-10 Antibody
Also known as Interleukin-10 (IL-10).
Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.
 IL10 ELISA Kit
 IL10 Recombinant
 IL10 Antibody
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Interleukin-11

 Interleukin-11 ELISA Kit
 Interleukin-11 Recombinant
 Interleukin-11 Antibody
Also known as Interleukin-11 (IL-11).
IL11: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Belongs to the IL-6 superfamily.

Protein type: Cell cycle regulation; Cytokine; Motility/polarity/chemotaxis; Secreted, signal peptide

Cellular Component: cy
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toplasm

Molecular Function: cytokine activity; growth factor activity; interleukin-11 receptor binding

Biological Process: negative regulation of hormone secretion; positive regulation of cell proliferation; positive regulation of MAPKKK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter
 Il11 ELISA Kit
 Il11 Recombinant
 Il11 Antibody
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Interleukin-12 subunit alpha

 Interleukin-12 subunit alpha ELISA Kit
 Interleukin-12 subunit alpha Recombinant
 Interleukin-12 subunit alpha Antibody
Also known as Interleukin-12 subunit alpha (IL-12A) (Cytotoxic lymphocyte maturation factor 35 kDa subunit) (CLMF p35) (IL-12 subunit p35).
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.
 IL12A ELISA Kit
 IL12A Recombinant
 IL12A Antibody
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Interleukin-12 subunit beta

 Interleukin-12 subunit beta ELISA Kit
 Interleukin-12 subunit beta Recombinant
 Interleukin-12 subunit beta Antibody
Also known as Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40).
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
 IL12B ELISA Kit
 IL12B Recombinant
 IL12B Antibody
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Interleukin-13

 Interleukin-13 ELISA Kit
 Interleukin-13 Recombinant
 Interleukin-13 Antibody
Also known as Interleukin-13 (IL-13).
Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.
 IL13 ELISA Kit
 IL13 Recombinant
 IL13 Antibody
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Interleukin-15

 Interleukin-15 ELISA Kit
 Interleukin-15 Recombinant
 Interleukin-15 Antibody
Also known as Interleukin-15 (IL-15).
Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha ().
 IL15 ELISA Kit
 IL15 Recombinant
 IL15 Antibody
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Interleukin-17A

 Interleukin-17A ELISA Kit
 Interleukin-17A Recombinant
 Interleukin-17A Antibody
Also known as Interleukin-17A (IL-17) (IL-17A).
Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines.
 IL17A ELISA Kit
 IL17A Recombinant
 IL17A Antibody
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Interleukin-17B

 Interleukin-17B ELISA Kit
 Interleukin-17B Recombinant
 Interleukin-17B Antibody
Also known as Interleukin-17B (IL-17B) (Cytokine CX1) (Cytokine-like protein ZCYTO7) (Neuronal interleukin-17-related factor).
IL17B: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. Belongs to the IL-17 family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: cytokine activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; receptor binding

Biological Process: cell surface receptor linked signal transduction; neutr
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ophil chemotaxis
 Il17b ELISA Kit
 Il17b Recombinant
 Il17b Antibody
 Nirf ELISA Kit
 Nirf Recombinant
 Nirf Antibody
 Zcyto7 ELISA Kit
 Zcyto7 Recombinant
 Zcyto7 Antibody
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Interleukin-17C

 Interleukin-17C ELISA Kit
 Interleukin-17C Recombinant
 Interleukin-17C Antibody
Also known as Interleukin-17C (Il-17c) (Cytokine CX2).
IL17C: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. Belongs to the IL-17 family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: cytokine activity; hematopoietin/interferon-class (D200-domain
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) cytokine receptor binding

Biological Process: cell surface receptor linked signal transduction; neutrophil differentiation
 Il17c ELISA Kit
 Il17c Recombinant
 Il17c Antibody
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Interleukin-17D

 Interleukin-17D ELISA Kit
 Interleukin-17D Recombinant
 Interleukin-17D Antibody
Also known as Interleukin-17D (IL-17D) (Interleukin-27) (IL-27).
IL17D: Induces expression of IL-6, IL-8, and GM-CSF from endothelial cells. Belongs to the IL-17 family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 13q11

Cellular Component: extracellular space

Molecular Function: cytokine activity; hematopoietin/i
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nterferon-class (D200-domain) cytokine receptor binding

Biological Process: cell surface receptor linked signal transduction; inflammatory response
 IL17D ELISA Kit
 IL17D Recombinant
 IL17D Antibody
 UNQ3096/PRO21175 ELISA Kit
 UNQ3096/PRO21175 Recombinant
 UNQ3096/PRO21175 Antibody
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Interleukin-17F

 Interleukin-17F ELISA Kit
 Interleukin-17F Recombinant
 Interleukin-17F Antibody
Also known as Interleukin-17F (IL-17F).
IL17F: Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6). CANDF6 is a rare disorder with altered immune responses and i
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mpaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. Belongs to the IL-17 family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: cytokine activity; cytokine binding; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; protein homodimerization activity

Biological Process: cartilage development; cell surface receptor linked signal transduction; cytokine biosynthetic process; lymphotoxin A biosynthetic process; negative regulation of angiogenesis; positive regulation of transcription from RNA polymerase II promoter; regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; regulation of interleukin-2 biosynthetic process; regulation of interleukin-6 biosynthetic process; regulation of interleukin-8 biosynthetic process; regulation of transforming growth factor beta receptor signaling pathway
 Il17f ELISA Kit
 Il17f Recombinant
 Il17f Antibody
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Interleukin-18

 Interleukin-18 ELISA Kit
 Interleukin-18 Recombinant
 Interleukin-18 Antibody
Also known as Interleukin-18 (IL-18).
Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
 IL18 ELISA Kit
 IL18 Recombinant
 IL18 Antibody
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Interleukin-19

 Interleukin-19 ELISA Kit
 Interleukin-19 Recombinant
 Interleukin-19 Antibody
Also known as Interleukin-19 (IL-19).
IL19: May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis. Belongs to the IL-10 family.

Protein type: Apoptosis; Cytokine; Secreted; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: cytokine activity

Biological Process: immune response;
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inflammatory response; interleukin-6 biosynthetic process; positive regulation of JAK-STAT cascade
 Il19 ELISA Kit
 Il19 Recombinant
 Il19 Antibody
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Interleukin-2

 Interleukin-2 ELISA Kit
 Interleukin-2 Recombinant
 Interleukin-2 Antibody
Also known as Interleukin-2 (IL-2) (T-cell growth factor) (TCGF).
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells ().
 IL2 ELISA Kit
 IL2 Recombinant
 IL2 Antibody
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Interleukin-20

 Interleukin-20 ELISA Kit
 Interleukin-20 Recombinant
 Interleukin-20 Antibody
Also known as Interleukin-20 (IL-20) (Cytokine Zcyto10).
IL20: Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3. Belongs to the IL-10 family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: cytokine activity; interleukin-20 receptor binding; interleukin-22 receptor bi
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nding

Biological Process: immune response; inflammatory response; positive regulation of JAK-STAT cascade; positive regulation of osteoclast differentiation; STAT protein nuclear translocation
 Il20 ELISA Kit
 Il20 Recombinant
 Il20 Antibody
 Zcyto10 ELISA Kit
 Zcyto10 Recombinant
 Zcyto10 Antibody
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Interleukin-21

 Interleukin-21 ELISA Kit
 Interleukin-21 Recombinant
 Interleukin-21 Antibody
Also known as Interleukin-21 (IL-21).
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with
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IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
 IL21 ELISA Kit
 IL21 Recombinant
 IL21 Antibody
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Interleukin-22

 Interleukin-22 ELISA Kit
 Interleukin-22 Recombinant
 Interleukin-22 Antibody
Also known as Interleukin-22 (IL-22) (Cytokine Zcyto18) (IL-10-related T-cell-derived-inducible factor) (IL-TIF).
IL22: Cytokine that contributes to the inflammatory response in vivo. Belongs to the IL-10 family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; protein binding

Biological Process: cell-cell signaling; immune response; inflammatory response; positive regulation of JAK-STAT cascade
 IL22 ELISA Kit
 IL22 Recombinant
 IL22 Antibody
 ILTIF ELISA Kit
 ILTIF Recombinant
 ILTIF Antibody
 ZCYTO18 ELISA Kit
 ZCYTO18 Recombinant
 ZCYTO18 Antibody
 UNQ3099/PRO10096 ELISA Kit
 UNQ3099/PRO10096 Recombinant
 UNQ3099/PRO10096 Antibody
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Interleukin-22b

 Interleukin-22b ELISA Kit
 Interleukin-22b Recombinant
 Interleukin-22b Antibody
Also known as Interleukin-22b (IL-22b) (IL-10-related T-cell-derived-inducible factor beta) (IL-TIF beta) (IL-TIFb).
Cytokine that contributes to the inflammatory response in vivo.
 Il22b ELISA Kit
 Il22b Recombinant
 Il22b Antibody
 Iltifb ELISA Kit
 Iltifb Recombinant
 Iltifb Antibody
Table BarTOPTable Bar
 

Interleukin-23 subunit alpha

 Interleukin-23 subunit alpha ELISA Kit
 Interleukin-23 subunit alpha Recombinant
 Interleukin-23 subunit alpha Antibody
Also known as Interleukin-23 subunit alpha (IL-23 subunit alpha) (IL-23-A) (Interleukin-23 subunit p19) (IL-23p19).
IL23A: Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of I
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L12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Belongs to the IL-6 superfamily.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: interleukin-23 receptor binding

Biological Process: defense response to Gram-negative bacterium; negative regulation of interleukin-10 production; positive regulation of activated T cell proliferation; positive regulation of defense response to virus by host; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of interferon-gamma production; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of interleukin-17 production; positive regulation of memory T cell differentiation; positive regulation of natural killer cell proliferation; positive regulation of NK T cell activation; positive regulation of NK T cell proliferation; positive regulation of osteoclast differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of T-helper 1 type immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of tyrosine phosphorylation of Stat4 protein; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of tyrosine phosphorylation of Stat1 protein; T cell proliferation
 Il23a ELISA Kit
 Il23a Recombinant
 Il23a Antibody
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Interleukin-24

 Interleukin-24 ELISA Kit
 Interleukin-24 Recombinant
 Interleukin-24 Antibody
Also known as Interleukin-24 (IL-24) (Cytokine-like protein Mob-5).
may function in proliferation of fibroblasts during wound healing; human homologue suppresses the growth and colony formation of tumor cells [RGD, Feb 2006]
 Il24 ELISA Kit
 Il24 Recombinant
 Il24 Antibody
 Mob5 ELISA Kit
 Mob5 Recombinant
 Mob5 Antibody
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Interleukin-25

 Interleukin-25 ELISA Kit
 Interleukin-25 Recombinant
 Interleukin-25 Antibody
Also known as Interleukin-25 (IL-25) (Interleukin-17E) (IL-17E).
IL25: Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses. Belongs to the IL-17 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; interleukin-17E receptor binding
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Biological Process: cell surface receptor linked signal transduction; inflammatory response
 IL25 ELISA Kit
 IL25 Recombinant
 IL25 Antibody
 IL17E ELISA Kit
 IL17E Recombinant
 IL17E Antibody
 UNQ3120/PRO10272 ELISA Kit
 UNQ3120/PRO10272 Recombinant
 UNQ3120/PRO10272 Antibody
Table BarTOPTable Bar
 

Interleukin-26

 Interleukin-26 ELISA Kit
 Interleukin-26 Recombinant
 Interleukin-26 Antibody
Also known as Interleukin-26 (IL-26) (Protein AK155).
IL26: May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferat
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ion of intestinal epithelial cells. Is inhibited by heparin. Belongs to the IL-10 family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: cytosol; extracellular space

Molecular Function: cytokine activity

Biological Process: cell-cell signaling; immune response; inflammatory response; negative regulation of epithelial cell proliferation; positive regulation of cytokine secretion; positive regulation of JAK-STAT cascade; positive regulation of protein kinase B signaling cascade; positive regulation of stress-activated MAPK cascade; positive regulation of transcription from RNA polymerase II promoter
 IL26 ELISA Kit
 IL26 Recombinant
 IL26 Antibody
 AK155 ELISA Kit
 AK155 Recombinant
 AK155 Antibody
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Interleukin-27 subunit alpha

 Interleukin-27 subunit alpha ELISA Kit
 Interleukin-27 subunit alpha Recombinant
 Interleukin-27 subunit alpha Antibody
Also known as Interleukin-27 subunit alpha (IL-27 subunit alpha) (IL-27-A) (IL27-A) (Interleukin-30) (p28).
IL27-alpha: Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not
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memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon- gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK- dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL-27 subunit p28 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP- 10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replivation. Belongs to the IL-6 superfamily.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 16p11

Cellular Component: extracellular region; extracellular space

Molecular Function: interleukin-27 receptor binding; receptor binding

Biological Process: positive regulation of interferon-gamma biosynthetic process; regulation of T cell proliferation; regulation of T-helper 1 cell differentiation
 IL27 ELISA Kit
 IL27 Recombinant
 IL27 Antibody
 IL27A ELISA Kit
 IL27A Recombinant
 IL27A Antibody
 IL30 ELISA Kit
 IL30 Recombinant
 IL30 Antibody
Table BarTOPTable Bar
 

Interleukin-27 subunit beta

 Interleukin-27 subunit beta ELISA Kit
 Interleukin-27 subunit beta Recombinant
 Interleukin-27 subunit beta Antibody
Also known as Interleukin-27 subunit beta (IL-27 subunit beta) (IL-27B) (Epstein-Barr virus-induced gene 3 protein homolog).
IL27-beta: Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among
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its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon- gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. Belongs to the type I cytokine receptor family. Type 3 subfamily.

Protein type: Secreted; Secreted, signal peptide

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-27 receptor binding; protein binding

Biological Process: T cell proliferation
 Ebi3 ELISA Kit
 Ebi3 Recombinant
 Ebi3 Antibody
 Il27b ELISA Kit
 Il27b Recombinant
 Il27b Antibody
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Interleukin-3

 Interleukin-3 ELISA Kit
 Interleukin-3 Recombinant
 Interleukin-3 Antibody
Also known as Interleukin-3 (IL-3) (Hematopoietic growth factor) (Mast cell growth factor) (MCGF) (Multipotential colony-stimulating factor) (P-cell-stimulating factor).
IL3: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and
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the monocytes-macrophages. Belongs to the IL-3 family.

Protein type: Apoptosis; Cell cycle regulation; Cytokine; Oncoprotein; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; interleukin-3 receptor binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: cell-cell signaling; cytokine and chemokine mediated signaling pathway; embryonic hemopoiesis; MAPKKK cascade; nervous system development; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of myeloid leukocyte differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of tyrosine phosphorylation of Stat5 protein
 IL3 ELISA Kit
 IL3 Recombinant
 IL3 Antibody
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Interleukin-31

 Interleukin-31 ELISA Kit
 Interleukin-31 Recombinant
 Interleukin-31 Antibody
Also known as Interleukin-31 (IL-31).
IL31: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity

Protein type: Cytokine; Secreted; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: cytokine activity; hematopoietin/interferon-class (D200-domain)
>>>
cytokine receptor binding; oncostatin-M receptor binding; protein binding
 Il31 ELISA Kit
 Il31 Recombinant
 Il31 Antibody
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Interleukin-32

 Interleukin-32 ELISA Kit
 Interleukin-32 Recombinant
 Interleukin-32 Antibody
Also known as Interleukin-32 (IL-32) (Natural killer cells protein 4) (Tumor necrosis factor alpha-inducing factor).
IL32: Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF- alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: cytosol; membrane

Molecular Function:
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protein binding

Biological Process: cell adhesion; defense response
 IL32 ELISA Kit
 IL32 Recombinant
 IL32 Antibody
 NK4 ELISA Kit
 NK4 Recombinant
 NK4 Antibody
 TAIF ELISA Kit
 TAIF Recombinant
 TAIF Antibody
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Interleukin-33

 Interleukin-33 ELISA Kit
 Interleukin-33 Recombinant
 Interleukin-33 Antibody
Also known as Interleukin-33 (IL-33).
IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splici
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ng.

Protein type: Cytokine

Molecular Function: cytokine activity

Biological Process: defense response to virus; macrophage activation during immune response; microglial cell activation during immune response; negative regulation of immunoglobulin secretion; negative regulation of interferon-gamma production; negative regulation of leukocyte migration; negative regulation of T-helper 1 type immune response; positive regulation of cytokine production; positive regulation of immunoglobulin secretion; positive regulation of inflammatory response; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of interleukin-5 production; positive regulation of interleukin-6 production; positive regulation of macrophage activation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of T-helper 2 type immune response; positive regulation of transcription from RNA polymerase II promoter; T-helper 2 type immune response
 Il33 ELISA Kit
 Il33 Recombinant
 Il33 Antibody
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Interleukin-34

 Interleukin-34 ELISA Kit
 Interleukin-34 Recombinant
 Interleukin-34 Antibody
Also known as Interleukin-34 (IL-34).
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone
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resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 ().
 Il34 ELISA Kit
 Il34 Recombinant
 Il34 Antibody
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Interleukin-36 alpha

 Interleukin-36 alpha ELISA Kit
 Interleukin-36 alpha Recombinant
 Interleukin-36 alpha Antibody
Also known as Interleukin-36 alpha (FIL1 epsilon) (Interleukin-1 epsilon) (IL-1 epsilon) (Interleukin-1 family member 6) (IL-1F6).
IL1F6: Belongs to the IL-1 family.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 2q12-q14.1

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; interleukin-1 receptor binding

Biological Process: cytokine and chemokine mediated signaling pathway
 IL36A ELISA Kit
 IL36A Recombinant
 IL36A Antibody
 FIL1E ELISA Kit
 FIL1E Recombinant
 FIL1E Antibody
 IL1E ELISA Kit
 IL1E Recombinant
 IL1E Antibody
 IL1F6 ELISA Kit
 IL1F6 Recombinant
 IL1F6 Antibody
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Interleukin-36 beta

 Interleukin-36 beta ELISA Kit
 Interleukin-36 beta Recombinant
 Interleukin-36 beta Antibody
Also known as Interleukin-36 beta (FIL1 eta) (Interleukin-1 eta) (IL-1 eta) (Interleukin-1 family member 8) (IL-1F8) (Interleukin-1 homolog 2) (IL-1H2).
The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported
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. [provided by RefSeq, Jul 2008]
 IL36B ELISA Kit
 IL36B Recombinant
 IL36B Antibody
 IL1F8 ELISA Kit
 IL1F8 Recombinant
 IL1F8 Antibody
 IL1H2 ELISA Kit
 IL1H2 Recombinant
 IL1H2 Antibody
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Interleukin-36 gamma

 Interleukin-36 gamma ELISA Kit
 Interleukin-36 gamma Recombinant
 Interleukin-36 gamma Antibody
Also known as Interleukin-36 gamma (IL-1-related protein 2) (IL-1RP2) (Interleukin-1 epsilon) (IL-1 epsilon) (Interleukin-1 family member 9) (IL-1F9) (Interleukin-1 homolog 1) (IL-1H1).
Il1f9: Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response. Belongs to the IL-1 family. 2 isoforms of the
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human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 2q12-q21

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; interleukin-1 receptor binding

Biological Process: cell-cell signaling; cytokine and chemokine mediated signaling pathway
 IL36G ELISA Kit
 IL36G Recombinant
 IL36G Antibody
 IL1E ELISA Kit
 IL1E Recombinant
 IL1E Antibody
 IL1F9 ELISA Kit
 IL1F9 Recombinant
 IL1F9 Antibody
 IL1H1 ELISA Kit
 IL1H1 Recombinant
 IL1H1 Antibody
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Interleukin-37

 Interleukin-37 ELISA Kit
 Interleukin-37 Recombinant
 Interleukin-37 Antibody
Also known as Interleukin-37 (FIL1 zeta) (IL-1X) (Interleukin-1 family member 7) (IL-1F7) (Interleukin-1 homolog 4) (IL-1H) (IL-1H4) (Interleukin-1 zeta) (IL-1 zeta) (Interleukin-1-related protein) (IL-1RP1) (Interleukin-23) (IL-37).
IL37: Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. Belong
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s to the IL-1 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 2q12-q14.1

Cellular Component: cytoplasm; extracellular region; extracellular space; nucleolus; nucleus

Molecular Function: cytokine activity; interleukin-1 receptor binding

Biological Process: cytokine and chemokine mediated signaling pathway
 IL37 ELISA Kit
 IL37 Recombinant
 IL37 Antibody
 FIL1Z ELISA Kit
 FIL1Z Recombinant
 FIL1Z Antibody
 IL1F7 ELISA Kit
 IL1F7 Recombinant
 IL1F7 Antibody
 IL1H4 ELISA Kit
 IL1H4 Recombinant
 IL1H4 Antibody
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Interleukin-4

 Interleukin-4 ELISA Kit
 Interleukin-4 Recombinant
 Interleukin-4 Antibody
Also known as Interleukin-4 (IL-4) (B-cell IgG differentiation factor) (B-cell growth factor 1) (B-cell stimulatory factor 1) (BSF-1) (IGG1 induction factor) (Lymphocyte stimulatory factor 1).
IL4: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-ce
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lls. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Belongs to the IL-4/IL-13 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Cellular Component: external side of plasma membrane; extracellular space

Molecular Function: cytokine activity

Biological Process: B cell activation; B cell costimulation; cholesterol metabolic process; defense response to protozoan; innate immune response in mucosa; microglial cell activation; myeloid dendritic cell differentiation; negative regulation of acute inflammatory response; negative regulation of chronic inflammatory response; negative regulation of macrophage activation; negative regulation of nitric oxide biosynthetic process; negative regulation of osteoclast differentiation; negative regulation of T cell activation; negative regulation of transcription, DNA-dependent; positive regulation of activated T cell proliferation; positive regulation of B cell activation; positive regulation of B cell proliferation; positive regulation of cell proliferation; positive regulation of chemokine biosynthetic process; positive regulation of defense response to virus by host; positive regulation of immunoglobulin production; positive regulation of interleukin-10 production; positive regulation of interleukin-13 production; positive regulation of isotype switching to IgE isotypes; positive regulation of isotype switching to IgG isotypes; positive regulation of mast cell degranulation; positive regulation of MHC class II biosynthetic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of T cell differentiation; positive regulation of T cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of immune response; regulation of inflammatory response; regulation of proton transport; T-helper 1 cell lineage commitment; T-helper 2 cell differentiation
 Il4 ELISA Kit
 Il4 Recombinant
 Il4 Antibody
 Il-4 ELISA Kit
 Il-4 Recombinant
 Il-4 Antibody
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Interleukin-5

 Interleukin-5 ELISA Kit
 Interleukin-5 Recombinant
 Interleukin-5 Antibody
Also known as Interleukin-5 (IL-5) (B-cell differentiation factor I) (Eosinophil differentiation factor) (T-cell replacing factor) (TRF).
IL5: Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. Belongs to the IL-5 family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q31.
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1

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: cytokine and chemokine mediated signaling pathway; MAPKKK cascade; positive regulation of B cell proliferation; positive regulation of immunoglobulin secretion; positive regulation of peptidyl-tyrosine phosphorylation
 IL5 ELISA Kit
 IL5 Recombinant
 IL5 Antibody
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Interleukin-6

 Interleukin-6 ELISA Kit
 Interleukin-6 Recombinant
 Interleukin-6 Antibody
Also known as Interleukin-6 (ChIL-6) (IL-6).
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response ().
 IL6 ELISA Kit
 IL6 Recombinant
 IL6 Antibody
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Interleukin-7

 Interleukin-7 ELISA Kit
 Interleukin-7 Recombinant
 Interleukin-7 Antibody
Also known as Interleukin-7 (IL-7).
IL7: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cell cycle regulation; Cell development/different
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iation; Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8q12-q13

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; growth factor activity; protein binding

Biological Process: bone resorption; cell-cell signaling; humoral immune response; negative regulation of apoptosis; organ morphogenesis; positive regulation of B cell proliferation; positive regulation of cell proliferation; positive regulation of T cell differentiation; T cell lineage commitment
 IL7 ELISA Kit
 IL7 Recombinant
 IL7 Antibody
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Interleukin-8

 Interleukin-8 ELISA Kit
 Interleukin-8 Recombinant
 Interleukin-8 Antibody
Also known as Interleukin-8 (IL-8) (9E3) (C-X-C motif chemokine 8) (CEF-4) (Chemokine (C-X-C motif) ligand 8) (Embryo fibroblast protein 1) (EMF-1).
May be an autocrine factor that promotes the growth of fibroblasts and is involved in the neoplastic transformation of fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear cells as well as for heterophils.
 CXCL8 ELISA Kit
 CXCL8 Recombinant
 CXCL8 Antibody
 CEF4 ELISA Kit
 CEF4 Recombinant
 CEF4 Antibody
 EMF1 ELISA Kit
 EMF1 Recombinant
 EMF1 Antibody
 IL8 ELISA Kit
 IL8 Recombinant
 IL8 Antibody
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Interleukin-9

 Interleukin-9 ELISA Kit
 Interleukin-9 Recombinant
 Interleukin-9 Antibody
Also known as Interleukin-9 (IL-9) (Cytokine P40) (T-cell growth factor P40).
IL9: Supports IL-2 independent and IL-4 independent growth of helper T-cells. Belongs to the IL-7/IL-9 family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: cytokine activity; interleukin-9 receptor binding

Biological
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Process: positive regulation of cell growth; positive regulation of interleukin-5 biosynthetic process
 Il9 ELISA Kit
 Il9 Recombinant
 Il9 Antibody
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Proteins Root Name Listing
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