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Interleukin-1 receptor-associated kinase

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Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3 (By similarity).

Below are the list of possible Interleukin-1 receptor-associated kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Interleukin-1 receptor-associated kinase 1

 Interleukin-1 receptor-associated kinase 1 ELISA Kit
 Interleukin-1 receptor-associated kinase 1 Recombinant
 Interleukin-1 receptor-associated kinase 1 Antibody
Also known as Interleukin-1 receptor-associated kinase 1 (IRAK) (IRAK-1) (Pelle-like protein kinase) (mPLK).
IRAK1: a TKL kinase of the IRAK family. Involved in Toll/IL-1 signaling. One of two putative serine/threonine kinases that become associated with the interleukin-1 receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and
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mRNA stabilization. Extensively phosphorylated after its association with IL1-R-1. Polyubiquitinated; after cell stimulation with IL-1-beta. Polyubiquitination occurs with polyubiquitin chains linked through 'Lys-63'. Partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Three isoforms of the human protein and produced by alternative splicing. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1. Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2.

Protein type: EC 2.7.11.1; IRAK family; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group

Cellular Component: cytoplasm; lipid particle; membrane; nucleus

Molecular Function: heat shock protein binding; interleukin-1 receptor binding; kinase activity; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity

Biological Process: activation of NF-kappaB transcription factor; activation of NF-kappaB-inducing kinase; cytokine and chemokine mediated signaling pathway; inhibition of NF-kappaB transcription factor; innate immune response; JNK cascade; lipopolysaccharide-mediated signaling pathway; negative regulation of transcription, DNA-dependent; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon type I production; positive regulation of JNK activity; positive regulation of MAP kinase activity; positive regulation of smooth muscle cell proliferation; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein oligomerization; regulation of cytokine and chemokine mediated signaling pathway; response to lipopolysaccharide; response to peptidoglycan; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway
 Irak1 ELISA Kit
 Irak1 Recombinant
 Irak1 Antibody
 Il1rak ELISA Kit
 Il1rak Recombinant
 Il1rak Antibody
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Interleukin-1 receptor-associated kinase 3

 Interleukin-1 receptor-associated kinase 3 ELISA Kit
 Interleukin-1 receptor-associated kinase 3 Recombinant
 Interleukin-1 receptor-associated kinase 3 Antibody
Also known as Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M).
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative
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regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
 IRAK3 ELISA Kit
 IRAK3 Recombinant
 IRAK3 Antibody
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Interleukin-1 receptor-associated kinase 4

 Interleukin-1 receptor-associated kinase 4 ELISA Kit
 Interleukin-1 receptor-associated kinase 4 Recombinant
 Interleukin-1 receptor-associated kinase 4 Antibody
Also known as Interleukin-1 receptor-associated kinase 4 (IRAK-4).
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylate
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s initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections ().
 IRAK4 ELISA Kit
 IRAK4 Recombinant
 IRAK4 Antibody
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Interleukin-1 receptor-associated kinase-like 2

 Interleukin-1 receptor-associated kinase-like 2 ELISA Kit
 Interleukin-1 receptor-associated kinase-like 2 Recombinant
 Interleukin-1 receptor-associated kinase-like 2 Antibody
Also known as Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).
IRAK2: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding
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of PELI1. Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.

Protein type: IRAK family; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group

Chromosomal Location of Human Ortholog: 3p25.3

Cellular Component: cytoplasm; cytosol; endosome membrane; nucleus; plasma membrane

Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity; protein serine/threonine kinase activity

Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; inhibition of NF-kappaB transcription factor; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; protein amino acid phosphorylation; regulation of cytokine and chemokine mediated signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway
 IRAK2 ELISA Kit
 IRAK2 Recombinant
 IRAK2 Antibody
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