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Interleukin-12 receptor

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Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

Below are the list of possible Interleukin-12 receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Interleukin-12 receptor subunit beta-1

 Interleukin-12 receptor subunit beta-1 ELISA Kit
 Interleukin-12 receptor subunit beta-1 Recombinant
 Interleukin-12 receptor subunit beta-1 Antibody
Also known as Interleukin-12 receptor subunit beta-1 (IL-12 receptor subunit beta-1) (IL-12R subunit beta-1) (IL-12R-beta-1) (IL-12 receptor beta component) (CD antigen CD212).
IL12RB1: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates
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also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. Defects in IL12RB1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Belongs to the type I cytokine receptor family. Type 2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Cellular Component: external side of plasma membrane

Molecular Function: cytokine binding; interleukin-12 receptor activity; interleukin-12 receptor binding; interleukin-23 binding; interleukin-23 receptor activity

Biological Process: peptidyl-tyrosine phosphorylation; positive regulation of activated T cell proliferation; positive regulation of defense response to virus by host; positive regulation of interferon-gamma production; positive regulation of T-helper 1 type immune response
 Il12rb1 ELISA Kit
 Il12rb1 Recombinant
 Il12rb1 Antibody
 Il12rb ELISA Kit
 Il12rb Recombinant
 Il12rb Antibody
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Interleukin-12 receptor subunit beta-2

 Interleukin-12 receptor subunit beta-2 ELISA Kit
 Interleukin-12 receptor subunit beta-2 Recombinant
 Interleukin-12 receptor subunit beta-2 Antibody
Also known as Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2).
IL12RB2: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-ga
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mma production. Belongs to the type I cytokine receptor family. Type 2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Membrane protein, integral; Receptor, cytokine

Cellular Component: external side of plasma membrane

Molecular Function: protein binding; protein kinase binding

Biological Process: interferon-gamma production; peptidyl-tyrosine phosphorylation; positive regulation of interferon-gamma production; response to cytokine stimulus; response to lipopolysaccharide
 Il12rb2 ELISA Kit
 Il12rb2 Recombinant
 Il12rb2 Antibody
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