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Iodotyrosine deiodinase

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Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT) .

Below are the list of possible Iodotyrosine deiodinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Iodotyrosine deiodinase 1

 Iodotyrosine deiodinase 1 ELISA Kit
 Iodotyrosine deiodinase 1 Recombinant
 Iodotyrosine deiodinase 1 Antibody
Also known as Iodotyrosine deiodinase 1 (IYD-1) (Iodotyrosine dehalogenase 1).
IYD: Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine. Defects in IYD are the cause of thyroid dyshormonogenesis 4 (TDH4). A disorder due to thyroid dyshormonogenesis, causing severe hypothyroidism, goiter, excessive levels of iodotyrosine in serum and urine, and variable me
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ntal deficits derived from unrecognized and untreated hypothyroidism. Belongs to the nitroreductase family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.22.1.1; Membrane protein, integral; Oxidoreductase

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: cytoplasmic vesicle membrane; integral to plasma membrane; plasma membrane

Molecular Function: FMN binding; oxidoreductase activity; protein binding

Biological Process: thyroid hormone generation; thyroid hormone metabolic process; tyrosine metabolic process

Disease: Thyroid Dyshormonogenesis 4
 IYD ELISA Kit
 IYD Recombinant
 IYD Antibody
 C6orf71 ELISA Kit
 C6orf71 Recombinant
 C6orf71 Antibody
 DEHAL1 ELISA Kit
 DEHAL1 Recombinant
 DEHAL1 Antibody
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